CA2302438A1 - Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases - Google Patents
Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases Download PDFInfo
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- CA2302438A1 CA2302438A1 CA002302438A CA2302438A CA2302438A1 CA 2302438 A1 CA2302438 A1 CA 2302438A1 CA 002302438 A CA002302438 A CA 002302438A CA 2302438 A CA2302438 A CA 2302438A CA 2302438 A1 CA2302438 A1 CA 2302438A1
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- 230000002485 urinary effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4694597P | 1997-05-19 | 1997-05-19 | |
US4708497P | 1997-05-19 | 1997-05-19 | |
US60/047,084 | 1997-05-19 | ||
US60/046,945 | 1997-05-19 | ||
US5662397P | 1997-08-20 | 1997-08-20 | |
US60/056,623 | 1997-08-20 | ||
US6159097P | 1997-10-10 | 1997-10-10 | |
US60/061,590 | 1997-10-10 | ||
PCT/US1998/010174 WO1998052944A1 (fr) | 1997-05-19 | 1998-05-18 | Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2302438A1 true CA2302438A1 (fr) | 1998-11-26 |
Family
ID=27489113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002302438A Abandoned CA2302438A1 (fr) | 1997-05-19 | 1998-05-18 | Composes d'heteroarylcarboxamide actifs contre les etats pathologiques lies aux proteine tyrosine kinases |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1012150A4 (fr) |
AR (1) | AR015685A1 (fr) |
AU (1) | AU7687998A (fr) |
CA (1) | CA2302438A1 (fr) |
WO (1) | WO1998052944A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002536406A (ja) * | 1999-02-12 | 2002-10-29 | カナム メディカル コーポレイション | 細胞増殖の治療用アルキル化剤 |
GB9904103D0 (en) | 1999-02-24 | 1999-04-14 | Zeneca Ltd | Quinoline derivatives |
MXPA01010292A (es) | 1999-04-15 | 2002-10-23 | Squibb Bristol Myers Co | Inhibidores ciclicos de la proteina tirosina cinasa. |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US6903101B1 (en) | 2000-08-10 | 2005-06-07 | Bayer Pharmaceuticals Corporation | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
GB0322012D0 (en) * | 2003-09-19 | 2003-10-22 | Syngenta Participations Ag | Chemical compounds |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
EP1990048A3 (fr) * | 2007-05-08 | 2009-05-06 | Ulrike Wiebelitz | Thérapie pour l'hyperplasie bénigne de la prostate |
CN101980704A (zh) | 2008-03-17 | 2011-02-23 | 埃科特莱茵药品有限公司 | 选择性s1p1受体激动剂的给药方案 |
US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
CN108929271B (zh) * | 2018-06-29 | 2021-08-31 | 中国药科大学 | 酪氨酸酶抑制剂及其制备方法与用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3133418A1 (de) * | 1981-08-24 | 1983-03-10 | Basf Ag, 6700 Ludwigshafen | Thiazolyl- und isothiazolylcarbonsaeureanilide, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
EP0418667B1 (fr) * | 1989-09-22 | 1995-08-16 | BASF Aktiengesellschaft | Amides d'acides carboxyliques |
HU222234B1 (hu) * | 1990-05-18 | 2003-05-28 | Aventis Pharma Deutschland Gmbh. | Eljárás izoxazol-4-karbonsav-amidok és hidroxi-alkilidén-cián-ecetsav-amidok, a vegyületeket tartalmazó gyógyászati készítmények és az ismert vegyületeket tartalmazó rákellenes hatású gyógyszerkészítmények előállítására |
DE69310367T2 (de) * | 1992-07-10 | 1997-08-14 | Glaxo Lab Sa | Anilide-derivate |
US5342851A (en) * | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
GB9320299D0 (en) * | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
JPH07196637A (ja) * | 1993-11-24 | 1995-08-01 | Mitsui Toatsu Chem Inc | イソチアゾールカルボン酸アミド誘導体の製造法 |
US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
WO1995024190A2 (fr) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant |
US5721277A (en) * | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
US6020121A (en) * | 1995-09-29 | 2000-02-01 | Microcide Pharmaceuticals, Inc. | Inhibitors of regulatory pathways |
DE19539638A1 (de) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
EA003056B1 (ru) * | 1996-12-23 | 2002-12-26 | Дюпон Фармасьютикалз Компани | АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ |
CA2289517A1 (fr) * | 1997-05-30 | 1998-12-03 | Nippon Kayaku Kabushiki Kaisha | Nouveaux derives sulfonamides |
ES2239806T3 (es) * | 1997-06-19 | 2005-10-01 | Bristol-Myers Squibb Pharma Company | Inhibidores del factor xa con un grupo de especificidad neutro p1. |
US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
US6319920B1 (en) * | 1998-02-27 | 2001-11-20 | Syntex (U.S.A.) Llc | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives |
-
1998
- 1998-05-18 CA CA002302438A patent/CA2302438A1/fr not_active Abandoned
- 1998-05-18 WO PCT/US1998/010174 patent/WO1998052944A1/fr not_active Application Discontinuation
- 1998-05-18 EP EP98924794A patent/EP1012150A4/fr not_active Withdrawn
- 1998-05-18 AU AU76879/98A patent/AU7687998A/en not_active Abandoned
- 1998-05-19 AR ARP980102308 patent/AR015685A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998052944A1 (fr) | 1998-11-26 |
EP1012150A4 (fr) | 2002-05-29 |
AR015685A1 (es) | 2001-05-16 |
AU7687998A (en) | 1998-12-11 |
EP1012150A1 (fr) | 2000-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |