ZA97676B - Method for inducing death of neoplastic cells using piperazine derivatives. - Google Patents

Method for inducing death of neoplastic cells using piperazine derivatives.

Info

Publication number
ZA97676B
ZA97676B ZA9700676A ZA97676A ZA97676B ZA 97676 B ZA97676 B ZA 97676B ZA 9700676 A ZA9700676 A ZA 9700676A ZA 97676 A ZA97676 A ZA 97676A ZA 97676 B ZA97676 B ZA 97676B
Authority
ZA
South Africa
Prior art keywords
neoplastic cells
piperazine derivatives
inducing death
death
inducing
Prior art date
Application number
ZA9700676A
Other languages
English (en)
Inventor
Gabriel F Eilon
John W Jacobs
Original Assignee
Hitachi Chemical Co Ltd
Hitachi Chemical Res Ct Inc
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Chemical Co Ltd, Hitachi Chemical Res Ct Inc, Nippon Chemiphar Co filed Critical Hitachi Chemical Co Ltd
Publication of ZA97676B publication Critical patent/ZA97676B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9700676A 1996-01-26 1997-01-27 Method for inducing death of neoplastic cells using piperazine derivatives. ZA97676B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/592,540 US5733911A (en) 1996-01-26 1996-01-26 Method for inducing death of neoplastic cells using piperazne derivatives

Publications (1)

Publication Number Publication Date
ZA97676B true ZA97676B (en) 1997-08-25

Family

ID=24371096

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9700676A ZA97676B (en) 1996-01-26 1997-01-27 Method for inducing death of neoplastic cells using piperazine derivatives.

Country Status (14)

Country Link
US (3) US5733911A (fr)
EP (1) EP0877614B1 (fr)
JP (1) JP4117404B2 (fr)
KR (1) KR100468271B1 (fr)
CN (1) CN1220490C (fr)
AR (1) AR005569A1 (fr)
AT (1) ATE219676T1 (fr)
AU (1) AU731125B2 (fr)
CA (1) CA2242657A1 (fr)
DE (1) DE69713570T2 (fr)
ID (1) ID18975A (fr)
TW (1) TW475897B (fr)
WO (1) WO1997026881A1 (fr)
ZA (1) ZA97676B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT826681E (pt) * 1995-03-31 2003-02-28 Nippon Chemiphar Co Derivados de acido epoxi-succinico
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives
ES2201524T3 (es) * 1997-09-04 2004-03-16 Nippon Chemiphar Co., Ltd. Derivados de epoxisuccinamida.
EP1094063A1 (fr) 1999-10-18 2001-04-25 Applied Research Systems ARS Holding N.V. 9-(Pipérazinylalkyl)carbazoles comme modulateurs de Bax
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
EP1798217A1 (fr) * 2000-10-23 2007-06-20 Arizona Biomedical Research Commission Agents anticancers basés sur la régulation de la protéine de prénylation
WO2003044535A1 (fr) * 2001-11-22 2003-05-30 Mehmet Ozturk Methode, antigene et anticorps permettant de distinguer des cellules apoptotiques et viables
US9993460B2 (en) 2013-07-26 2018-06-12 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
PL407922A1 (pl) * 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55115878A (en) * 1979-02-27 1980-09-06 Taisho Pharmaceut Co Ltd Epoxysuccinic acid derivative
JPS55153778A (en) * 1979-05-17 1980-11-29 Taisho Pharmaceut Co Ltd Epoxysuccinylamino acid derivative
US4474800A (en) * 1980-05-13 1984-10-02 Taisho Pharmaceutical Co., Ltd. Epoxysuccinyl amino acid derivatives
JPS57169478A (en) * 1981-04-10 1982-10-19 Nippon Chemiphar Co Ltd Piperazine derivative
JPS6276A (ja) * 1985-03-26 1987-01-06 Toyo Jozo Co Ltd 酵素阻害性新規物質
JPH0832698B2 (ja) * 1987-05-08 1996-03-29 日本ケミファ株式会社 ピペラジン誘導体
CA2047226A1 (fr) * 1989-12-27 1991-06-28 Jun-Ichi Haruta Oxyde de 1,3,2-dioxathiolane
WO1993006143A1 (fr) * 1991-09-19 1993-04-01 Cray Valley Sa Resines de petrole thermiquement stables, leur procede de preparation et leur application a la formulation d'adhesifs thermofusibles
JPH0641067A (ja) * 1992-04-20 1994-02-15 Kitasato Inst:The 新規カルパイン阻害物質ｋｐ−１２４１及びその製造法
DK0603769T3 (da) * 1992-12-25 1999-06-14 Mitsubishi Chem Corp Alfa-aminoketonderivater
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives

Also Published As

Publication number Publication date
ID18975A (id) 1998-05-28
CN1212623A (zh) 1999-03-31
AU1840297A (en) 1997-08-20
DE69713570D1 (de) 2002-08-01
KR19990082064A (ko) 1999-11-15
ATE219676T1 (de) 2002-07-15
EP0877614A1 (fr) 1998-11-18
JP4117404B2 (ja) 2008-07-16
AR005569A1 (es) 1999-06-23
US5733911A (en) 1998-03-31
WO1997026881A1 (fr) 1997-07-31
US6054437A (en) 2000-04-25
AU731125B2 (en) 2001-03-22
TW475897B (en) 2002-02-11
CN1220490C (zh) 2005-09-28
JP2000505792A (ja) 2000-05-16
CA2242657A1 (fr) 1997-07-31
KR100468271B1 (ko) 2005-07-05
DE69713570T2 (de) 2003-01-23
EP0877614B1 (fr) 2002-06-26
US5859013A (en) 1999-01-12

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