AR005569A1 - Un metodo para inducir la muerte de celulas neoplasicas mediante derivados de la piperazina - Google Patents
Un metodo para inducir la muerte de celulas neoplasicas mediante derivados de la piperazinaInfo
- Publication number
- AR005569A1 AR005569A1 ARP970100324A ARP970100324A AR005569A1 AR 005569 A1 AR005569 A1 AR 005569A1 AR P970100324 A ARP970100324 A AR P970100324A AR P970100324 A ARP970100324 A AR P970100324A AR 005569 A1 AR005569 A1 AR 005569A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- formula
- group
- neoplastic cells
- alkyl group
- Prior art date
Links
- 210000005170 neoplastic cell Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000030833 cell death Effects 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un método para inducir la muerte celular de células neoplásicas que incluye el paso de administración de un compuesto de la fórmula (I), o de unasal del mismo farmacéuticamente aceptable, como agente quimioterapéutico primario oesenci almente en forma simultánea con otra quimioterapia, a unpaciente que presenta resistencia a múltiples drogas, efectuándose dicha administración en cantidades eficaces para inducir la muerte celular de lascélulas neoplásicas (fórmula(I)), dond e R1 es el grupo hidroxilo, C1-4 alcoxil, C1-4 alquilcarboniloximetoxil, fenil C1-2 alquilamino, 2,5-pirrolidinadiona-1-alcolxil (C1-4); o bien fórmula (II), donde X1 es una unión química o el grupo C1-2 alquileno, X2 es unhidrógeno o un gr upo carboxilo queforma un anillo de 5 miembros con X1 cuando X1 es el metileno; X3 es un hidrógeno o un grupo C1-2 alquilo; X4 es un hidrógeno o un grupo C1-2 alquilo;o X3 y X4 forman los dos un anillo de 5 miembros, en elcual por lo menos alguno de los elementos X2, X3 o X4 es un hidrógeno; R2 es el grupo C3-4alquilo; R3 es el gruo C1-4 alquilo, (fórmula (III)), donde n es un entero comprendido entre 0 y 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/592,540 US5733911A (en) | 1996-01-26 | 1996-01-26 | Method for inducing death of neoplastic cells using piperazne derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005569A1 true AR005569A1 (es) | 1999-06-23 |
Family
ID=24371096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100324A AR005569A1 (es) | 1996-01-26 | 1997-01-27 | Un metodo para inducir la muerte de celulas neoplasicas mediante derivados de la piperazina |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US5733911A (es) |
| EP (1) | EP0877614B1 (es) |
| JP (1) | JP4117404B2 (es) |
| KR (1) | KR100468271B1 (es) |
| CN (1) | CN1220490C (es) |
| AR (1) | AR005569A1 (es) |
| AT (1) | ATE219676T1 (es) |
| AU (1) | AU731125B2 (es) |
| CA (1) | CA2242657A1 (es) |
| DE (1) | DE69713570T2 (es) |
| ID (1) | ID18975A (es) |
| TW (1) | TW475897B (es) |
| WO (1) | WO1997026881A1 (es) |
| ZA (1) | ZA97676B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA000438B1 (ru) * | 1995-03-31 | 1999-08-26 | Ниппон Кемифар Ко., Лтд. | Производные эпоксиянтарной кислоты |
| US5733911A (en) * | 1996-01-26 | 1998-03-31 | Hitachi Chemical Co., Ltd. | Method for inducing death of neoplastic cells using piperazne derivatives |
| AU8997898A (en) * | 1997-09-04 | 1999-03-22 | Nippon Chemiphar Co. Ltd. | Epoxysuccinamide derivatives |
| EP1094063A1 (en) * | 1999-10-18 | 2001-04-25 | Applied Research Systems ARS Holding N.V. | 9-(Piperazinylalkyl)carbazoles as Bax-modulators |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| AU2002213408A1 (en) * | 2000-10-23 | 2002-05-06 | The Arizona Disease Control Research Commission | Anticancer agents based on regulation of protein prenylation |
| WO2003044535A1 (en) * | 2001-11-22 | 2003-05-30 | Mehmet Ozturk | Method, antigen and antibody for distinguishing viable and apoptotic cells |
| CN112472699A (zh) * | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
| PL407922A1 (pl) * | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55115878A (en) * | 1979-02-27 | 1980-09-06 | Taisho Pharmaceut Co Ltd | Epoxysuccinic acid derivative |
| JPS55153778A (en) * | 1979-05-17 | 1980-11-29 | Taisho Pharmaceut Co Ltd | Epoxysuccinylamino acid derivative |
| US4474800A (en) * | 1980-05-13 | 1984-10-02 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinyl amino acid derivatives |
| JPS57169478A (en) * | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
| JPS6276A (ja) * | 1985-03-26 | 1987-01-06 | Toyo Jozo Co Ltd | 酵素阻害性新規物質 |
| JPH0832698B2 (ja) * | 1987-05-08 | 1996-03-29 | 日本ケミファ株式会社 | ピペラジン誘導体 |
| US5214056A (en) * | 1989-12-27 | 1993-05-25 | Japan Tobacco Inc. | 1,3,2-dioxathiolane oxide derivative |
| WO1993006143A1 (fr) * | 1991-09-19 | 1993-04-01 | Cray Valley Sa | Resines de petrole thermiquement stables, leur procede de preparation et leur application a la formulation d'adhesifs thermofusibles |
| JPH0641067A (ja) * | 1992-04-20 | 1994-02-15 | Kitasato Inst:The | 新規カルパイン阻害物質ｋｐ−１２４１及びその製造法 |
| ES2124281T3 (es) * | 1992-12-25 | 1999-02-01 | Mitsubishi Chem Corp | Derivados de alfa-aminocetonas. |
| US5733911A (en) * | 1996-01-26 | 1998-03-31 | Hitachi Chemical Co., Ltd. | Method for inducing death of neoplastic cells using piperazne derivatives |
-
1996
- 1996-01-26 US US08/592,540 patent/US5733911A/en not_active Expired - Fee Related
-
1997
- 1997-01-24 WO PCT/US1997/001231 patent/WO1997026881A1/en active IP Right Grant
- 1997-01-24 JP JP52706097A patent/JP4117404B2/ja not_active Expired - Fee Related
- 1997-01-24 KR KR10-1998-0705786A patent/KR100468271B1/ko not_active IP Right Cessation
- 1997-01-24 CA CA002242657A patent/CA2242657A1/en not_active Abandoned
- 1997-01-24 DE DE69713570T patent/DE69713570T2/de not_active Expired - Fee Related
- 1997-01-24 AU AU18402/97A patent/AU731125B2/en not_active Ceased
- 1997-01-24 EP EP97903981A patent/EP0877614B1/en not_active Expired - Lifetime
- 1997-01-24 AT AT97903981T patent/ATE219676T1/de active
- 1997-01-24 CN CNB971926689A patent/CN1220490C/zh not_active Expired - Fee Related
- 1997-01-27 ZA ZA9700676A patent/ZA97676B/xx unknown
- 1997-01-27 ID IDP970229A patent/ID18975A/id unknown
- 1997-01-27 AR ARP970100324A patent/AR005569A1/es not_active Application Discontinuation
- 1997-03-14 TW TW086103221A patent/TW475897B/zh not_active IP Right Cessation
- 1997-12-10 US US08/987,816 patent/US5859013A/en not_active Expired - Fee Related
- 1997-12-10 US US08/988,056 patent/US6054437A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69713570T2 (de) | 2003-01-23 |
| TW475897B (en) | 2002-02-11 |
| ZA97676B (en) | 1997-08-25 |
| CA2242657A1 (en) | 1997-07-31 |
| EP0877614B1 (en) | 2002-06-26 |
| CN1212623A (zh) | 1999-03-31 |
| AU1840297A (en) | 1997-08-20 |
| ID18975A (id) | 1998-05-28 |
| WO1997026881A1 (en) | 1997-07-31 |
| AU731125B2 (en) | 2001-03-22 |
| US5859013A (en) | 1999-01-12 |
| JP2000505792A (ja) | 2000-05-16 |
| KR19990082064A (ko) | 1999-11-15 |
| KR100468271B1 (ko) | 2005-07-05 |
| US6054437A (en) | 2000-04-25 |
| ATE219676T1 (de) | 2002-07-15 |
| CN1220490C (zh) | 2005-09-28 |
| DE69713570D1 (de) | 2002-08-01 |
| JP4117404B2 (ja) | 2008-07-16 |
| US5733911A (en) | 1998-03-31 |
| EP0877614A1 (en) | 1998-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |