KR850006003A - 안트라퀴논 유도체의 제조방법 - Google Patents
안트라퀴논 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850006003A KR850006003A KR1019850000494A KR850000494A KR850006003A KR 850006003 A KR850006003 A KR 850006003A KR 1019850000494 A KR1019850000494 A KR 1019850000494A KR 850000494 A KR850000494 A KR 850000494A KR 850006003 A KR850006003 A KR 850006003A
- Authority
- KR
- South Korea
- Prior art keywords
- amino
- pharmaceutically acceptable
- bis
- compound
- surface area
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 하기 구조식(Ⅰ)화합물 또는 약학적으로 허용가능한 그의 산부가염 약 1-50mg/㎡(체표면적)과 약학적으로 허용가능한 담체로 구성되는 비경구적 단위투약 재형내의 조성물질.상기식에서 R1은 R2는 같거나 다를수 있으며 수소 또는 히드록시이고, A-B는 -CH=CH-또는 -CH2-CH2-; R3와 R4는 같거나 다를 수 있으며,(여기서, R5,R6,R7,R8,R9및 R10은 수소 또는 알킬(C1-C4), Ar은 아릴 또는 헤테로아릴, n은 0,1 또는 2)이다.
- 1,1-[에틸렌비스(이미노에틸렌이미노)]비스 [5,8-디히드록시-4-[(2-메텔아미노에틸)아미노)]안트라퀴논, 테트라하이드로클로라이드 약1-50mg/㎡(체표면적) 및 약학적으로 허용가능한 담체로 구성되는 비경구적 단위투약 제형내의 조성물질.
- 폴리[5,8-디히드록시-1,4-안트라퀴노닐렌이미노에틸렌-3,2-옥사졸리딘디일-트리메틸렌-2,3-옥사졸디린디일에틸렌이미노]약 1-50mg/㎡(체표면적)및 약학적으로 허용가능한 담체로 구성되는 비경구적 단위투약 제형내의 조성물질.
- 화합물 1,4-비스[2-벤질아미노에틸)아미노]-아미노]-2,3-디히드로-5,8-디히드록시안트라퀴논.
- 화합물 1,4-비스[(2-벤질아미노에틸)아미노]-5,8-디히드록시안트라퀴논, 디하이드로클로라이드.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58354084A | 1984-02-27 | 1984-02-27 | |
US583540 | 1984-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850006003A true KR850006003A (ko) | 1985-09-28 |
KR900004646B1 KR900004646B1 (ko) | 1990-07-02 |
Family
ID=24333530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850000494A KR900004646B1 (ko) | 1984-02-27 | 1985-01-26 | 안트라퀴논 유도체 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0154117B1 (ko) |
JP (1) | JPS60208939A (ko) |
KR (1) | KR900004646B1 (ko) |
AT (1) | ATE48942T1 (ko) |
AU (1) | AU581878B2 (ko) |
CA (1) | CA1255300A (ko) |
DE (1) | DE3574932D1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4540788A (en) * | 1983-07-14 | 1985-09-10 | American Cyanamid Company | Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones |
IL76002A0 (en) * | 1984-08-03 | 1985-12-31 | Boehringer Biochemia Srl | Amino-anthracenediones-platinum complexes useful as anti-cancer compounds |
WO1987003481A1 (en) * | 1985-12-05 | 1987-06-18 | American Biotechnology Co., Ltd. | Anthracycline type antitumor agents with l-ascorbic acid |
ES2033247T3 (es) * | 1986-03-07 | 1993-03-16 | American Cyanamid Company | Metodo para preparar una composicion farmaceutica a base de un compuesto antraquinonico. |
GB2245807A (en) * | 1990-06-28 | 1992-01-08 | Rank Cintel Ltd | Editing of object-based animated computer graphics |
DE59409088D1 (de) * | 1994-10-04 | 2000-02-24 | Lohmann Rudolf Lomapharm | Lösungen von Anthrachinonen zur parenteralen Applikation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA774443B (en) * | 1977-07-22 | 1978-06-28 | Allied Chem | Anthrquinone compounds as anti-cancer agents |
SE445996B (sv) * | 1977-08-15 | 1986-08-04 | American Cyanamid Co | Nya atrakinonderivat |
US4428882A (en) * | 1979-05-29 | 1984-01-31 | American Cyanamid Company | 1-(Aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones |
US4278605A (en) * | 1980-06-30 | 1981-07-14 | American Cyanamid Company | Heteroalkylenebisanthraquinones |
US4410524A (en) * | 1982-06-01 | 1983-10-18 | American Cyanamid Company | Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
-
1985
- 1985-01-14 DE DE8585100307T patent/DE3574932D1/de not_active Expired - Fee Related
- 1985-01-14 EP EP85100307A patent/EP0154117B1/en not_active Expired
- 1985-01-14 AT AT85100307T patent/ATE48942T1/de not_active IP Right Cessation
- 1985-01-26 KR KR1019850000494A patent/KR900004646B1/ko not_active IP Right Cessation
- 1985-02-25 CA CA000475025A patent/CA1255300A/en not_active Expired
- 1985-02-25 JP JP60034684A patent/JPS60208939A/ja active Pending
- 1985-02-26 AU AU39151/85A patent/AU581878B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
KR900004646B1 (ko) | 1990-07-02 |
EP0154117A1 (en) | 1985-09-11 |
AU3915185A (en) | 1985-09-05 |
AU581878B2 (en) | 1989-03-09 |
JPS60208939A (ja) | 1985-10-21 |
ATE48942T1 (de) | 1990-01-15 |
CA1255300A (en) | 1989-06-06 |
DE3574932D1 (de) | 1990-02-01 |
EP0154117B1 (en) | 1989-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19930527 Year of fee payment: 4 |
|
LAPS | Lapse due to unpaid annual fee |