ZA963154B - Arylalkyl pyridazinone - Google Patents

Arylalkyl pyridazinone

Info

Publication number
ZA963154B
ZA963154B ZA963154A ZA963154A ZA963154B ZA 963154 B ZA963154 B ZA 963154B ZA 963154 A ZA963154 A ZA 963154A ZA 963154 A ZA963154 A ZA 963154A ZA 963154 B ZA963154 B ZA 963154B
Authority
ZA
South Africa
Prior art keywords
pyridazinone
cooa
substd
halo
opt
Prior art date
Application number
ZA963154A
Other languages
English (en)
Inventor
Rochus Jonas
Michael Wolf
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA963154B publication Critical patent/ZA963154B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
ZA963154A 1995-04-20 1996-04-19 Arylalkyl pyridazinone ZA963154B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19514568A DE19514568A1 (de) 1995-04-20 1995-04-20 Arylalkyl-pyridazinone

Publications (1)

Publication Number Publication Date
ZA963154B true ZA963154B (en) 1996-12-06

Family

ID=7759974

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA963154A ZA963154B (en) 1995-04-20 1996-04-19 Arylalkyl pyridazinone

Country Status (21)

Country Link
US (2) US6399611B1 (cs)
EP (1) EP0738715B1 (cs)
JP (1) JP4005157B2 (cs)
KR (1) KR100428879B1 (cs)
CN (1) CN1159299C (cs)
AT (1) ATE231842T1 (cs)
AU (1) AU705025B2 (cs)
CA (1) CA2174472C (cs)
CZ (1) CZ291868B6 (cs)
DE (2) DE19514568A1 (cs)
DK (1) DK0738715T3 (cs)
ES (1) ES2191070T3 (cs)
HU (1) HU226198B1 (cs)
NO (1) NO307931B1 (cs)
PT (1) PT738715E (cs)
RU (1) RU2159236C2 (cs)
SI (1) SI0738715T1 (cs)
SK (1) SK284167B6 (cs)
TW (1) TW475927B (cs)
UA (1) UA43853C2 (cs)
ZA (1) ZA963154B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
JP4017214B2 (ja) 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体
WO1998008828A1 (fr) * 1996-08-27 1998-03-05 Nikken Chemicals Co., Ltd. Derives du 2-phenylmorpholin-5-one et composition pharmaceutique les comprenant
CN1173950C (zh) * 1998-10-06 2004-11-03 大日本制药株式会社 2,3-二取代的吡啶衍生物、其制备方法、含有其的药物组合物和用于制备中的中间体
DE19850701A1 (de) 1998-11-04 2000-05-11 Merck Patent Gmbh Benzoylpyridazine
CA2381802C (en) 1999-08-21 2010-12-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of roflumilast and salmeterol
RU2279428C2 (ru) * 2000-09-18 2006-07-10 Эйсай Ко., Лтд. Производные пиридазинона и триазинона и их применение в качестве фармацевтических препаратов
DE10064997A1 (de) * 2000-12-23 2002-06-27 Merck Patent Gmbh Benzoylpyridazine
EP1368035A1 (en) * 2001-02-12 2003-12-10 MERCK PATENT GmbH Use of type 4 phosphodiesterase inhibitors in myocardial diseases
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
CN1537018A (zh) 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
EP1389468A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS PROMOTING THE GUISON OF A BONE FRACTURE
DE10150517A1 (de) * 2001-10-12 2003-04-17 Merck Patent Gmbh Verwendung von Phosphodiesterase IV-Inhibitoren
JP2005515975A (ja) * 2001-10-31 2005-06-02 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング ４型ホスホジエステラーゼ阻害剤およびこれらの使用
ES2195785B1 (es) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US7074959B2 (en) * 2002-08-01 2006-07-11 New Mexico Highlands University Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
AU2004226353A1 (en) 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
CA2554797C (en) * 2004-02-04 2012-09-04 Altana Pharma Ag 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
WO2008072784A1 (en) * 2006-12-14 2008-06-19 Astellas Pharma Inc. Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents
US8466198B2 (en) * 2008-09-02 2013-06-18 Bruce Kneller Compositions comprising creatine salts and methods of use thereof
US20110052729A1 (en) * 2009-08-26 2011-03-03 Golini Jeffrey M Pharmaceutical or nutraceutical composition
MX2022008085A (es) 2016-03-16 2022-07-11 H Lee Moffitt Cancer Ct & Res Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t.
CN112512589A (zh) 2018-07-11 2021-03-16 H·李·莫菲特癌症中心研究有限公司 二聚体免疫调节化合物对抗基于cereblon的机制

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604863A (cs) * 1967-11-22 1972-04-17
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
GB1488330A (en) * 1973-12-19 1977-10-12 Smith Kline French Lab Dihydropyridazinones
DE2845456A1 (de) 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
SU1313346A3 (ru) * 1981-09-17 1987-05-23 Варнер-Ламберт,Компани (Фирма) Способ получени замещенных 6-арил-3(2 @ )-пиридазинонов
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
GR82072B (cs) * 1983-05-11 1984-12-13 Byk Gulden Lomberg Chem Fab
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4816454A (en) 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
US5175161A (en) * 1989-04-06 1992-12-29 Sankyo Company, Limited Occular hypotensive agents
AU6081690A (en) * 1989-08-10 1991-02-14 Glaxo Inc. Pyridazinones having cardiotonic and beta block activity
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
DE19502699A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl-thiadiazinone

Also Published As

Publication number Publication date
EP0738715A3 (de) 1998-06-17
KR100428879B1 (ko) 2004-07-15
AU705025B2 (en) 1999-05-13
SK48796A3 (en) 1997-02-05
SK284167B6 (sk) 2004-10-05
DE19514568A1 (de) 1996-10-24
NO961578D0 (no) 1996-04-19
US6399611B1 (en) 2002-06-04
ES2191070T3 (es) 2003-09-01
CN1142493A (zh) 1997-02-12
EP0738715A2 (de) 1996-10-23
CA2174472C (en) 2008-10-21
HUP9601034A3 (en) 1999-03-01
UA43853C2 (uk) 2002-01-15
US20020111356A1 (en) 2002-08-15
EP0738715B1 (de) 2003-01-29
HU226198B1 (en) 2008-06-30
DK0738715T3 (da) 2003-05-26
PT738715E (pt) 2003-06-30
HUP9601034A2 (en) 1996-12-30
HU9601034D0 (en) 1996-06-28
SI0738715T1 (en) 2003-10-31
NO961578L (no) 1996-10-21
ATE231842T1 (de) 2003-02-15
DE59610081D1 (de) 2003-03-06
AU5071196A (en) 1996-10-31
JP4005157B2 (ja) 2007-11-07
US6531473B2 (en) 2003-03-11
TW475927B (en) 2002-02-11
CZ291868B6 (cs) 2003-06-18
CZ113296A3 (en) 1996-11-13
CA2174472A1 (en) 1996-10-21
JPH08291145A (ja) 1996-11-05
CN1159299C (zh) 2004-07-28
KR960037662A (ko) 1996-11-19
NO307931B1 (no) 2000-06-19
RU2159236C2 (ru) 2000-11-20

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