ZA9610600B - Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2 - Google Patents

Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2

Info

Publication number
ZA9610600B
ZA9610600B ZA9610600A ZA9610600A ZA9610600B ZA 9610600 B ZA9610600 B ZA 9610600B ZA 9610600 A ZA9610600 A ZA 9610600A ZA 9610600 A ZA9610600 A ZA 9610600A ZA 9610600 B ZA9610600 B ZA 9610600B
Authority
ZA
South Africa
Prior art keywords
acetyl
cyanophanylala
paph
amidinophenylalanine
palme
Prior art date
Application number
ZA9610600A
Other languages
English (en)
Inventor
Chi-Hsin Richard King
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA9610600B publication Critical patent/ZA9610600B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
ZA9610600A 1995-12-20 1996-12-17 Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2 ZA9610600B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57556995A 1995-12-20 1995-12-20

Publications (1)

Publication Number Publication Date
ZA9610600B true ZA9610600B (en) 1997-06-20

Family

ID=24300839

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9610600A ZA9610600B (en) 1995-12-20 1996-12-17 Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2

Country Status (27)

Country Link
EP (1) EP0868526B1 (ko)
JP (1) JP4044614B2 (ko)
KR (1) KR100438879B1 (ko)
CN (1) CN1087349C (ko)
AR (1) AR005119A1 (ko)
AT (1) ATE222293T1 (ko)
AU (1) AU717995B2 (ko)
BR (1) BR9612059A (ko)
CA (1) CA2241210C (ko)
CZ (1) CZ295362B6 (ko)
DE (1) DE69623038T2 (ko)
DK (1) DK0868526T3 (ko)
EE (1) EE03698B1 (ko)
ES (1) ES2179957T3 (ko)
HK (1) HK1017384A1 (ko)
IL (1) IL125003A (ko)
MX (1) MX9804997A (ko)
NO (1) NO319678B1 (ko)
NZ (1) NZ324159A (ko)
PL (1) PL185541B1 (ko)
PT (1) PT868526E (ko)
RU (1) RU2170764C2 (ko)
SK (1) SK281432B6 (ko)
TR (1) TR199801107T2 (ko)
UA (1) UA48993C2 (ko)
WO (1) WO1997022712A1 (ko)
ZA (1) ZA9610600B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9916732A (pt) * 1999-01-02 2001-09-25 Aventis Pharma Gmbh Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa)
EP1016663A1 (en) * 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
RU2250212C2 (ru) * 2000-01-28 2005-04-20 Авентис Фарма Дойчланд Гмбх Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов
EP1127884A1 (en) * 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
GB0306267D0 (en) * 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
CN106946724B (zh) * 2017-04-07 2019-03-22 苏州汉德创宏生化科技有限公司 单胺基抑制剂类中间体2-乙酰氨基-2-苄基丙二酸单乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE69213546T2 (de) * 1991-05-13 1997-02-27 Fujisawa Pharmaceutical Co Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
ATE262536T1 (de) * 1994-04-26 2004-04-15 Aventis Pharma Inc Faktor xa inhibitoren

Also Published As

Publication number Publication date
RU2170764C2 (ru) 2001-07-20
CZ195698A3 (cs) 1999-01-13
DE69623038T2 (de) 2002-12-12
ES2179957T3 (es) 2003-02-01
EP0868526B1 (en) 2002-08-14
CN1087349C (zh) 2002-07-10
ATE222293T1 (de) 2002-08-15
IL125003A (en) 2001-12-23
DE69623038D1 (de) 2002-09-19
HK1017384A1 (en) 1999-11-19
DK0868526T3 (da) 2002-12-02
NO982868L (no) 1998-08-19
NO982868D0 (no) 1998-06-19
UA48993C2 (uk) 2002-09-16
TR199801107T2 (xx) 1998-10-21
CA2241210C (en) 2002-05-14
NO319678B1 (no) 2005-09-05
NZ324159A (en) 1999-07-29
JP2000501618A (ja) 2000-02-15
PL185541B1 (pl) 2003-05-30
WO1997022712A1 (en) 1997-06-26
JP4044614B2 (ja) 2008-02-06
PL327314A1 (en) 1998-12-07
EE03698B1 (et) 2002-04-15
EP0868526A1 (en) 1998-10-07
BR9612059A (pt) 1999-02-23
IL125003A0 (en) 1999-01-26
AU1125197A (en) 1997-07-14
CA2241210A1 (en) 1997-06-26
CN1205742A (zh) 1999-01-20
CZ295362B6 (cs) 2005-07-13
KR20000064486A (ko) 2000-11-06
KR100438879B1 (ko) 2004-07-16
SK281432B6 (sk) 2001-03-12
SK85598A3 (en) 1998-12-02
MX9804997A (es) 1998-09-30
AU717995B2 (en) 2000-04-06
PT868526E (pt) 2002-12-31
EE9800188A (et) 1998-12-15
AR005119A1 (es) 1999-04-14

Similar Documents

Publication Publication Date Title
EP0739687A3 (en) Polishing method and device
EP0998324A4 (en) VASCULAR SHUTTERING APPARATUS AND RELATED METHOD
EP0810153A4 (en) METHOD AND APPARATUS FOR LINKING AN ARTICLE
ZA964733B (en) Ob protein compositions and methods
IL117409A0 (en) Flow electroporation chamber and method
PL322589A1 (en) Radiotracer-labelled peptides for use in diagnostics and therapy
EP0809829A4 (en) DEVICE AND METHOD
AU7483698A (en) Multi-element fluid delivery apparatus and methods
GB2299913B (en) Telephony system and method
EP0732351A3 (de) Verfahren und Vorrichtung zur Herstellung von Polyamiden
AU4528496A (en) Method for generating proteolytic enzymes specific against selected peptide sequence
GB2303127B (en) Sulfide-oxidizing bacteria and process therewith
GB2303228B (en) Reminder apparatus and method
EP0695801A3 (en) Peptide compositions derived from yeast proteins, process for their preparation and their uses
ZA9610600B (en) Novel process for preparing n-acetyl(l)-4-cyanophanylala-nine ac-(L)-phe (4-cn)-OH and N-acetyl-(L)-p- amidinophenylalanine-cyclohexylglycine-beta.(3-N-methylpyridinium)-alanine Ac-(L)-paph-chg-palme(3)-NH2
AU6480696A (en) Quilting method and apparatus
EP0742612A3 (en) Method and device for connecting multiple connectors
GB2300656B (en) Edging means and method
SI0868526T1 (en) PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-BETA-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH2
ZA969617B (en) Method and agents for inhibiting protein aging.
EP0737014A3 (en) Coding apparatus and methods
HUP9902322A3 (en) Novel process for preparing n-acetyl(l)-4-cyanophenylalanine and ac-(l)-paph-chg-palme(3)-nh2
GB9500163D0 (en) Sealing,methods,means and apparatus
IL118324A0 (en) Immunoregulatory polypeptide and its uses
GB9517483D0 (en) Sealing apparatus and method