HK1017384A1 - NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE AC-(L)-PHE(4-CN)-OH AND N-ACETYL-(L)-P-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYLCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE AC(L)-PAPH-CHG-PALME(3)-NH2 - Google Patents

NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE AC-(L)-PHE(4-CN)-OH AND N-ACETYL-(L)-P-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYLCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE AC(L)-PAPH-CHG-PALME(3)-NH2

Info

Publication number
HK1017384A1
HK1017384A1 HK99102351A HK99102351A HK1017384A1 HK 1017384 A1 HK1017384 A1 HK 1017384A1 HK 99102351 A HK99102351 A HK 99102351A HK 99102351 A HK99102351 A HK 99102351A HK 1017384 A1 HK1017384 A1 HK 1017384A1
Authority
HK
Hong Kong
Prior art keywords
acetyl
cyclohexylglylcine
paph
amidinophenylalanine
palme
Prior art date
Application number
HK99102351A
Other languages
English (en)
Inventor
Chi-Hsin King
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of HK1017384A1 publication Critical patent/HK1017384A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
HK99102351A 1995-12-20 1999-05-25 NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE AC-(L)-PHE(4-CN)-OH AND N-ACETYL-(L)-P-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYLCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE AC(L)-PAPH-CHG-PALME(3)-NH2 HK1017384A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57556995A 1995-12-20 1995-12-20
PCT/US1996/019005 WO1997022712A1 (en) 1995-12-20 1996-11-25 NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH¿2?

Publications (1)

Publication Number Publication Date
HK1017384A1 true HK1017384A1 (en) 1999-11-19

Family

ID=24300839

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99102351A HK1017384A1 (en) 1995-12-20 1999-05-25 NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE AC-(L)-PHE(4-CN)-OH AND N-ACETYL-(L)-P-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYLCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE AC(L)-PAPH-CHG-PALME(3)-NH2

Country Status (27)

Country Link
EP (1) EP0868526B1 (ko)
JP (1) JP4044614B2 (ko)
KR (1) KR100438879B1 (ko)
CN (1) CN1087349C (ko)
AR (1) AR005119A1 (ko)
AT (1) ATE222293T1 (ko)
AU (1) AU717995B2 (ko)
BR (1) BR9612059A (ko)
CA (1) CA2241210C (ko)
CZ (1) CZ295362B6 (ko)
DE (1) DE69623038T2 (ko)
DK (1) DK0868526T3 (ko)
EE (1) EE03698B1 (ko)
ES (1) ES2179957T3 (ko)
HK (1) HK1017384A1 (ko)
IL (1) IL125003A (ko)
MX (1) MX9804997A (ko)
NO (1) NO319678B1 (ko)
NZ (1) NZ324159A (ko)
PL (1) PL185541B1 (ko)
PT (1) PT868526E (ko)
RU (1) RU2170764C2 (ko)
SK (1) SK281432B6 (ko)
TR (1) TR199801107T2 (ko)
UA (1) UA48993C2 (ko)
WO (1) WO1997022712A1 (ko)
ZA (1) ZA9610600B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1016663A1 (en) * 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
ID29979A (id) 1999-01-02 2001-10-25 Aventis Pharma Gmbh Turunan asam malonat baru, proses pembuatannya, penggunaannya dan komposisi sediaan farmasi yang mengandung bahan tersebut (penghambatan aktivitas faktor xa)
BR0107804A (pt) * 2000-01-28 2002-10-22 Aventis Pharma Gmbh Processo para a preparação de acetil-amidiniofenilalanil-ciclohexilglicil-piridinioa laninamidas
EP1127884A1 (en) 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
GB0306267D0 (en) 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
CN106946724B (zh) * 2017-04-07 2019-03-22 苏州汉德创宏生化科技有限公司 单胺基抑制剂类中间体2-乙酰氨基-2-苄基丙二酸单乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
AU662522B2 (en) * 1991-05-13 1995-09-07 Fujisawa Pharmaceutical Co., Ltd. New peptide compound and a process for the preparation thereof
SK286094B6 (sk) * 1994-04-26 2008-03-05 Aventis Pharmaceuticals Inc. Zlúčenina špecificky inhibujúca aktivitu faktora Xa, farmaceutická kompozícia s jej obsahom a jej použitie

Also Published As

Publication number Publication date
MX9804997A (es) 1998-09-30
IL125003A (en) 2001-12-23
AU1125197A (en) 1997-07-14
AU717995B2 (en) 2000-04-06
NO982868D0 (no) 1998-06-19
ATE222293T1 (de) 2002-08-15
NZ324159A (en) 1999-07-29
UA48993C2 (uk) 2002-09-16
CZ195698A3 (cs) 1999-01-13
KR100438879B1 (ko) 2004-07-16
EE03698B1 (et) 2002-04-15
DE69623038D1 (de) 2002-09-19
KR20000064486A (ko) 2000-11-06
WO1997022712A1 (en) 1997-06-26
PL327314A1 (en) 1998-12-07
CA2241210A1 (en) 1997-06-26
TR199801107T2 (xx) 1998-10-21
EE9800188A (et) 1998-12-15
EP0868526B1 (en) 2002-08-14
AR005119A1 (es) 1999-04-14
JP2000501618A (ja) 2000-02-15
DE69623038T2 (de) 2002-12-12
RU2170764C2 (ru) 2001-07-20
PL185541B1 (pl) 2003-05-30
DK0868526T3 (da) 2002-12-02
SK85598A3 (en) 1998-12-02
NO982868L (no) 1998-08-19
CA2241210C (en) 2002-05-14
CN1205742A (zh) 1999-01-20
ZA9610600B (en) 1997-06-20
PT868526E (pt) 2002-12-31
BR9612059A (pt) 1999-02-23
CZ295362B6 (cs) 2005-07-13
SK281432B6 (sk) 2001-03-12
JP4044614B2 (ja) 2008-02-06
IL125003A0 (en) 1999-01-26
ES2179957T3 (es) 2003-02-01
EP0868526A1 (en) 1998-10-07
CN1087349C (zh) 2002-07-10
NO319678B1 (no) 2005-09-05

Similar Documents

Publication Publication Date Title
EP0739687A3 (en) Polishing method and device
EP0771614A3 (en) Motorized clamping and measuring device
EP0810153A4 (en) METHOD AND APPARATUS FOR LINKING AN ARTICLE
PL322589A1 (en) Radiotracer-labelled peptides for use in diagnostics and therapy
EP0998324A4 (en) VASCULAR SHUTTERING APPARATUS AND RELATED METHOD
EP0809829A4 (en) DEVICE AND METHOD
ZA964733B (en) Ob protein compositions and methods
EP0732351A3 (de) Verfahren und Vorrichtung zur Herstellung von Polyamiden
HUP9600436A2 (en) Apparatus and process for polimerizing olefins in gas phase
GB2303228B (en) Reminder apparatus and method
GB9514964D0 (en) Anchoring apparatus and method
GB2285964B (en) Label-applying method and apparatus
HUP0105460A2 (en) Hemiasterlin analogs and process for preparation thereof
HK1017384A1 (en) NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE AC-(L)-PHE(4-CN)-OH AND N-ACETYL-(L)-P-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYLCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE AC(L)-PAPH-CHG-PALME(3)-NH2
GB2306359B (en) Wafer polishing method and wafer polishing apparatus
ZA9610826B (en) Sonic method and apparatus for cosmetic applications
SI0868526T1 (en) PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-BETA-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH2
GB2299295B (en) Improvements in and relating to apparatus for labelling articles
GB9509853D0 (en) Separating and sequencing apparatus
GB9506719D0 (en) Improvements relating to labelling and/or packaging apparatus and methods
HUP9902322A3 (en) Novel process for preparing n-acetyl(l)-4-cyanophenylalanine and ac-(l)-paph-chg-palme(3)-nh2
GB2294790B (en) Article characterisation method and apparatus
GB2306176B (en) Texturing process and apparatus
GB9517483D0 (en) Sealing apparatus and method
GB2338318B (en) Reminder apparatus and method

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111125