ZA957283B - Alkylbenzoylguanidine derivatives - Google Patents

Alkylbenzoylguanidine derivatives

Info

Publication number
ZA957283B
ZA957283B ZA957283A ZA957283A ZA957283B ZA 957283 B ZA957283 B ZA 957283B ZA 957283 A ZA957283 A ZA 957283A ZA 957283 A ZA957283 A ZA 957283A ZA 957283 B ZA957283 B ZA 957283B
Authority
ZA
South Africa
Prior art keywords
opt
ch2f
substd
chf2
halo
Prior art date
Application number
ZA957283A
Other languages
English (en)
Inventor
Rolf Gericke
Manfred Baumgarth
Norbert Beier
Dieter Dorsch
Klaus-Otto Minck
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA957283B publication Critical patent/ZA957283B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
ZA957283A 1994-08-31 1995-08-30 Alkylbenzoylguanidine derivatives ZA957283B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4430916A DE4430916A1 (de) 1994-08-31 1994-08-31 Alkyl-benzoylguanidin-Derivate

Publications (1)

Publication Number Publication Date
ZA957283B true ZA957283B (en) 1996-04-02

Family

ID=6527018

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA957283A ZA957283B (en) 1994-08-31 1995-08-30 Alkylbenzoylguanidine derivatives

Country Status (20)

Country Link
US (1) US5840761A (no)
EP (1) EP0699663B1 (no)
JP (1) JP3732873B2 (no)
KR (1) KR100406687B1 (no)
CN (1) CN1055920C (no)
AT (1) ATE172962T1 (no)
AU (1) AU701558B2 (no)
BR (1) BR9503854A (no)
CA (1) CA2157143C (no)
CZ (1) CZ288015B6 (no)
DE (2) DE4430916A1 (no)
ES (1) ES2126190T3 (no)
HU (1) HU222401B1 (no)
NO (1) NO305901B1 (no)
PL (1) PL180902B1 (no)
RU (1) RU2142940C1 (no)
SK (1) SK281051B6 (no)
TW (1) TW397814B (no)
UA (1) UA41353C2 (no)
ZA (1) ZA957283B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
DE19624178A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
KR20010080597A (ko) * 1998-11-26 2001-08-22 플레믹 크리스티안 인슐린 비의존성 당뇨병 치료를 위한 벤조일구아니딘의 용도
DE10001879A1 (de) 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US7365070B2 (en) * 2002-12-04 2008-04-29 Ore Pharmaceuticals Inc. Modulators of melanocortin receptor
BRPI0410022A (pt) * 2003-05-06 2006-04-25 Merck Patent Gmbh processo para a cristalização de sais de guanidìnio
USD781236S1 (en) 2016-01-14 2017-03-14 Premier Accessory Group LLC Charging device
US10344002B2 (en) 2016-09-26 2019-07-09 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE59302959D1 (de) * 1992-02-15 1996-07-25 Hoechst Ag 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
DE59307360D1 (de) * 1992-02-15 1997-10-23 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE59304166D1 (de) * 1992-07-01 1996-11-21 Hoechst Ag 3,4,5-Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE147375T1 (de) * 1992-09-22 1997-01-15 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika
TW250479B (no) * 1992-12-15 1995-07-01 Hoechst Ag
DE59306029D1 (de) * 1992-12-16 1997-05-07 Hoechst Ag 3,5-Substituierte Aminobenzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
MY128187A (en) * 1993-06-23 2007-01-31 Icn Switzerland Ag Preparation for skin and mucous membrane
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
HUT75094A (en) 1997-04-28
DE59504122D1 (de) 1998-12-10
NO305901B1 (no) 1999-08-16
CA2157143C (en) 2009-02-17
EP0699663A1 (de) 1996-03-06
KR960007538A (ko) 1996-03-22
PL180902B1 (pl) 2001-04-30
HU9502501D0 (en) 1995-10-30
CA2157143A1 (en) 1996-03-01
TW397814B (en) 2000-07-11
BR9503854A (pt) 1996-09-17
SK281051B6 (sk) 2000-11-07
ES2126190T3 (es) 1999-03-16
JPH08188568A (ja) 1996-07-23
RU2142940C1 (ru) 1999-12-20
KR100406687B1 (ko) 2004-07-19
CN1128753A (zh) 1996-08-14
ATE172962T1 (de) 1998-11-15
AU701558B2 (en) 1999-01-28
JP3732873B2 (ja) 2006-01-11
CN1055920C (zh) 2000-08-30
US5840761A (en) 1998-11-24
EP0699663B1 (de) 1998-11-04
UA41353C2 (uk) 2001-09-17
SK105595A3 (en) 1996-03-06
PL310225A1 (en) 1996-03-04
AU3025195A (en) 1996-02-15
NO953405D0 (no) 1995-08-30
HU222401B1 (hu) 2003-06-28
CZ288015B6 (cs) 2001-04-11
DE4430916A1 (de) 1996-03-07
CZ220395A3 (en) 1996-03-13
NO953405L (no) 1996-03-01

Similar Documents

Publication Publication Date Title
ZA957283B (en) Alkylbenzoylguanidine derivatives
PL310224A1 (en) Novel derivatives of heterocyclyl-benzoyl guanidine, method of obtaining them and pharmaceutic preparation and method of preparing same
IL88784A (en) Substituted 6-phenyldihydro-3-(2h)- pyridazinones, a process for their preparation and pharmaceutical preparations containing these compounds
NO305242B1 (no) Arylbenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler
DK0694537T3 (da) Heterocyclyloxy-benzoylguanidinderivater, fremstilling deraf og anvendelse deraf som inhibitorer for den cellulære Na+/H+-antiporter
NO306991B1 (no) Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler
DE59505429D1 (de) Alkyl-5-methylsulfonyl-benzoyl-guanidin-Derivate