ZA948927B - Melatonin derivatives for use in treating sleep disorders - Google Patents

Melatonin derivatives for use in treating sleep disorders

Info

Publication number
ZA948927B
ZA948927B ZA948927A ZA948927A ZA948927B ZA 948927 B ZA948927 B ZA 948927B ZA 948927 A ZA948927 A ZA 948927A ZA 948927 A ZA948927 A ZA 948927A ZA 948927 B ZA948927 B ZA 948927B
Authority
ZA
South Africa
Prior art keywords
sleep disorders
treating sleep
melatonin derivatives
melatonin
derivatives
Prior art date
Application number
ZA948927A
Other languages
English (en)
Inventor
Michael Edward Flaugh
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA948927B publication Critical patent/ZA948927B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA948927A 1993-11-18 1994-11-10 Melatonin derivatives for use in treating sleep disorders ZA948927B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/154,332 US5654325A (en) 1993-11-18 1993-11-18 Melatonin derivatives for use in treating sleep disorders

Publications (1)

Publication Number Publication Date
ZA948927B true ZA948927B (en) 1996-05-10

Family

ID=22550932

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA948927A ZA948927B (en) 1993-11-18 1994-11-10 Melatonin derivatives for use in treating sleep disorders

Country Status (21)

Country Link
US (1) US5654325A (ko)
EP (1) EP0655243B1 (ko)
JP (1) JPH07196493A (ko)
KR (1) KR950013508A (ko)
CN (1) CN1092958C (ko)
AT (1) ATE222491T1 (ko)
AU (1) AU684313B2 (ko)
CA (1) CA2135709C (ko)
CZ (1) CZ288835B6 (ko)
DE (1) DE69431199T2 (ko)
DK (1) DK0655243T3 (ko)
ES (1) ES2181702T3 (ko)
HU (1) HUT72069A (ko)
IL (1) IL111580A (ko)
NO (1) NO309964B1 (ko)
NZ (1) NZ264892A (ko)
PH (1) PH31098A (ko)
PT (1) PT655243E (ko)
RU (1) RU2146140C1 (ko)
SG (1) SG50505A1 (ko)
ZA (1) ZA948927B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0748627A3 (en) * 1995-06-14 1997-05-21 Lilly Co Eli Melatonin agonists for the treatment of benign forms of hyperplasia of the prostate
CA2357114C (en) * 2001-03-22 2010-06-29 Pooger Properties Ltd. Use of melatonin in the manufacture of a medicament for treating attention deficit hyperactive disorder
WO2002079153A1 (en) * 2001-03-28 2002-10-10 Biocatalytics, Inc. Method for producing tryptamine derivatives
IL144900A (en) * 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
CA2500198A1 (en) * 2002-09-26 2004-04-08 Pooger Properties Limited Combined use of methylphenidate and melatonin for treating attention-deficit hyperactive disorder
JP4933097B2 (ja) 2003-12-19 2012-05-16 株式会社メニコン 糖尿病および糖尿病合併症の治療・改善方法
WO2005062851A2 (en) * 2003-12-22 2005-07-14 Pappolla Miguel A Indole-3-propionamide and derivatives thereof
CA2556753C (en) * 2004-02-20 2014-11-25 Lifescape Biosciences Incorporated Compositions and methods for sleep regulation
DE102005008312A1 (de) * 2005-02-17 2006-08-24 Birds Pharma Gmbh Berolina Innovative Research & Development Services Verwendung deuterierter N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]acatamide und deren pharmazeutisch verträglicher Salze sowie diese Verbindungen enthaltende Arzneimittel
US20060223877A1 (en) * 2005-03-31 2006-10-05 Zemlan Frank P Methods of treatment utilizing certain melatonin derivatives
TWI402261B (zh) * 2006-06-19 2013-07-21 Takeda Pharmaceutical 三環化合物及其醫藥組成物
ES2324849A1 (es) * 2007-10-25 2009-08-17 Ferrer Internacional, S.A. Compuestos de indano.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087444A (en) * 1976-09-08 1978-05-02 Eli Lilly And Company Amides as ovulation inhibitors
IT1148618B (it) * 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
EP0126630B1 (en) * 1983-05-18 1987-09-16 Monash University The use of melatonin for the manufacture of a medicament
US4600723A (en) * 1983-05-18 1986-07-15 Monash University Method for minimizing disturbances in circadian rhythms of bodily performance and function
US4614807A (en) * 1984-10-04 1986-09-30 Eli Lilly And Company 6,7-dihalomelatonins
US4687763A (en) * 1985-02-25 1987-08-18 Massachusetts Institute Of Technology Composition and method for increasing levels or release of brain serotonin
US4997845A (en) * 1987-02-02 1991-03-05 Eli Lilly And Company β-alkylmelatonins as ovulation inhibitors
US5093352A (en) * 1988-11-14 1992-03-03 Whitby Research, Inc. Antidepressant agents
AU616907B2 (en) * 1987-08-17 1991-11-14 Whitby Research, Inc. Melatonin analogues
JPH0418034A (ja) * 1990-05-11 1992-01-22 Kanegafuchi Chem Ind Co Ltd 点眼組成物
US5242941A (en) * 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
IT1251544B (it) * 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
PT100973A (pt) * 1991-10-18 1994-06-30 Alza Corp Dispositivo e composicoes farmaceuticas para a administracao de melatonina por via transdermica
US5196435A (en) * 1991-11-21 1993-03-23 Eli Lilly And Company Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma
IT1254995B (it) * 1992-06-24 1995-10-11 Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
IT1255199B (it) * 1992-07-01 1995-10-20 Franco Fraschini Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin

Also Published As

Publication number Publication date
SG50505A1 (en) 1998-07-20
JPH07196493A (ja) 1995-08-01
NO309964B1 (no) 2001-04-30
CN1107701A (zh) 1995-09-06
PH31098A (en) 1998-02-05
AU7777794A (en) 1995-05-25
NO944339L (no) 1995-05-19
NZ264892A (en) 1997-07-27
RU94040886A (ru) 1996-09-20
CA2135709A1 (en) 1995-05-19
RU2146140C1 (ru) 2000-03-10
HU9403300D0 (en) 1995-01-30
US5654325A (en) 1997-08-05
DE69431199T2 (de) 2003-03-27
NO944339D0 (no) 1994-11-14
ES2181702T3 (es) 2003-03-01
CN1092958C (zh) 2002-10-23
CA2135709C (en) 2007-01-02
DE69431199D1 (de) 2002-09-26
DK0655243T3 (da) 2002-10-07
ATE222491T1 (de) 2002-09-15
KR950013508A (ko) 1995-06-15
CZ276594A3 (en) 1995-07-12
IL111580A (en) 1999-10-28
IL111580A0 (en) 1995-01-24
EP0655243A3 (en) 1995-10-11
PT655243E (pt) 2002-11-29
HUT72069A (en) 1996-03-28
EP0655243A2 (en) 1995-05-31
AU684313B2 (en) 1997-12-11
EP0655243B1 (en) 2002-08-21
CZ288835B6 (cs) 2001-09-12

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