ZA946770B - Hybrid toxin - Google Patents

Hybrid toxin

Info

Publication number
ZA946770B
ZA946770B ZA946770A ZA946770A ZA946770B ZA 946770 B ZA946770 B ZA 946770B ZA 946770 A ZA946770 A ZA 946770A ZA 946770 A ZA946770 A ZA 946770A ZA 946770 B ZA946770 B ZA 946770B
Authority
ZA
South Africa
Prior art keywords
hybrid toxin
domain
region
protein
terminus
Prior art date
Application number
ZA946770A
Other languages
English (en)
Inventor
Hendrik Jan Bosch
Willem Johannes Stiekema
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of ZA946770B publication Critical patent/ZA946770B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA946770A 1993-09-02 1994-09-02 Hybrid toxin ZA946770B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939318207A GB9318207D0 (en) 1993-09-02 1993-09-02 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
ZA946770B true ZA946770B (en) 1996-03-04

Family

ID=10741404

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA946770A ZA946770B (en) 1993-09-02 1994-09-02 Hybrid toxin

Country Status (18)

Country Link
US (2) US5736131A (xx)
EP (1) EP0719335B1 (xx)
JP (1) JPH09502343A (xx)
KR (1) KR100360918B1 (xx)
AT (1) ATE329033T1 (xx)
AU (1) AU691522B2 (xx)
BR (1) BR9407377A (xx)
CA (1) CA2168011C (xx)
DE (1) DE69434758T2 (xx)
ES (1) ES2262136T3 (xx)
GB (1) GB9318207D0 (xx)
IL (1) IL110829A (xx)
PL (1) PL181408B1 (xx)
RU (1) RU2210593C2 (xx)
TW (1) TW430669B (xx)
UA (1) UA57698C2 (xx)
WO (1) WO1995006730A1 (xx)
ZA (1) ZA946770B (xx)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0413019B1 (en) * 1989-02-24 2001-10-04 Monsanto Technology LLC Synthetic plant genes and method for preparation
GB9318207D0 (en) 1993-09-02 1993-10-20 Sandoz Ltd Improvements in or relating to organic compounds
US6780408B1 (en) 1993-09-02 2004-08-24 Syngenta Participations Ag Genes encoding hybrid bacillus thuringiensis toxins
US5593881A (en) * 1994-05-06 1997-01-14 Mycogen Corporation Bacillus thuringiensis delta-endotoxin
US6063756A (en) 1996-09-24 2000-05-16 Monsanto Company Bacillus thuringiensis cryET33 and cryET34 compositions and uses therefor
CA2272843C (en) * 1996-11-20 2009-11-10 Ecogen, Inc. Broad-spectrum delta-endotoxins
US6713063B1 (en) 1996-11-20 2004-03-30 Monsanto Technology, Llc Broad-spectrum δ-endotoxins
US6017534A (en) 1996-11-20 2000-01-25 Ecogen, Inc. Hybrid Bacillus thuringiensis δ-endotoxins with novel broad-spectrum insecticidal activity
US5942664A (en) * 1996-11-27 1999-08-24 Ecogen, Inc. Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants
US6121436A (en) * 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
EP1555319A3 (en) * 1997-10-20 2006-03-15 GTC Biotherapeutics, Inc. Modified nucleic acid sequences and method to increasing mRNA levels and protein expression in cell systems
US6218188B1 (en) 1997-11-12 2001-04-17 Mycogen Corporation Plant-optimized genes encoding pesticidal toxins
AU774176B2 (en) * 1997-11-12 2004-06-17 Mycogen Corporation Plant-optimised genes encoding pesticidal toxins
US6121521A (en) * 1998-04-01 2000-09-19 Novartis Ag Chimeric insecticidal protein and DNA coding therefor
EP1099760A1 (en) * 1999-11-09 2001-05-16 Centrum Voor Plantenveredelings- En Reproduktieonderzoek (Cpro) Bacillus thuringiensis Cry1Ia-Cry1Ba hybrid toxins
ES2243543T3 (es) * 2000-08-25 2005-12-01 Syngenta Participations Ag Hibridos de proteinas cristalinas de bacillus thurigiensis.
CA2446215A1 (en) * 2001-05-04 2002-11-14 North Carolina State University Polymer conjugates of insecticidal peptides or nucleic acids and methods of use thereof
US20030108585A1 (en) * 2001-05-04 2003-06-12 Roe R. Michael Polymer conjugates of insecticidal peptides or nucleic acids or insecticides and methods of use thereof
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
WO2003064621A2 (en) * 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
ATE508188T1 (de) * 2002-02-01 2011-05-15 Life Technologies Corp Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit
US7557186B2 (en) * 2002-03-27 2009-07-07 Council Of Scientific & Industrial Research Chimeric CrylE δ endotoxin and methods of controlling insects
US7053266B2 (en) * 2002-03-27 2006-05-30 Council Of Scientfic And Industrial Research Chimeric cry1E δendotoxin and methods of controlling insects
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US7393922B2 (en) * 2003-08-29 2008-07-01 The Ohio State University Research Foundation Insecticidal Cry4Ba proteins with enhanced toxicity
CA2771677A1 (en) 2005-08-31 2007-03-08 Monsanto Technology Llc Nucleotide sequences encoding insecticidal proteins
CN100510081C (zh) 2005-10-17 2009-07-08 华中农业大学 苏云金芽胞杆菌的杀虫晶体蛋白基因cry7Bal
AU2007228981B2 (en) * 2006-03-21 2012-10-04 BASF Agricultural Solutions Seed US LLC Novel genes encoding insecticidal proteins
EP2021476B1 (en) 2006-05-26 2014-07-09 Monsanto Technology, LLC Corn plant and seed corresponding to transgenic event mon89034 and methods for detection and use thereof
US9522937B2 (en) 2007-03-28 2016-12-20 Syngenta Participations Ag Insecticidal proteins
BRPI0809352B1 (pt) * 2007-03-28 2017-03-28 Syngenta Participations Ag proteína inseticida híbrida projetada, molécula de ácido nucleico codificadora da dita proteína,cassete de expressão, vetor recombinante, célula hospedeira transgênica, composição inseticida, métodos de produção da dita proteína e de uma planta transgênica resistente a insetos e método de controle de insetos".
WO2008145406A1 (en) * 2007-06-01 2008-12-04 Bayer Bioscience N.V. Novel genes encoding insecticidal proteins
MX348698B (es) 2008-12-16 2017-06-26 Syngenta Participations Ag Evento 5307 del maiz.
AU2010221135A1 (en) 2009-03-05 2011-09-29 Metabolix, Inc. Propagation of transgenic plants
DK2419441T3 (en) 2009-04-17 2015-04-27 Dow Agrosciences Llc Insecticidal dig-3-cry toxins
BR112012009381A2 (pt) 2009-10-02 2017-03-01 Syngenta Participations Ag "proteínas inseticidas"
KR20120115316A (ko) * 2009-12-16 2012-10-17 다우 아그로사이언시즈 엘엘씨 밤나방 및 유럽 옥수수 천공충을 방제하기 위한 살곤충성 단백질 조합, 및 곤충 내성 관리 방법
JP5969921B2 (ja) * 2009-12-16 2016-08-17 ダウ アグロサイエンシィズ エルエルシー 抵抗性昆虫の対応のためのＣｒｙ１Ｂｅと組み合わせたＣｒｙ１Ｄａの使用
AR079500A1 (es) * 2009-12-16 2012-02-01 Dow Agrosciences Llc Uso combinado de proteinas cry1ca y cry1fa para el manejo de la resistencia de insectos
WO2011084622A1 (en) * 2009-12-16 2011-07-14 Dow Agrosciences Llc Combined use of cry1ca and cry1ab proteins for insect resistance management
JP5907892B2 (ja) * 2009-12-16 2016-04-26 ダウ アグロサイエンシィズ エルエルシー 抵抗性昆虫の対応のためのＣｒｙ１Ｂｅと組み合わせたＣｒｙ１Ａｂの使用
US20120317682A1 (en) * 2009-12-16 2012-12-13 Dow Agrosciences Llc Combined use of vip3ab and cry1fa for management of resistant insects
AR079505A1 (es) * 2009-12-16 2012-02-01 Dow Agrosciences Llc Uso de cry1da en combinacion con cry1ca para el manejo de insectos resistentes
NZ601096A (en) * 2009-12-16 2014-10-31 Dow Agrosciences Llc Combined use of cry1da and cry1fa proteins for insect resistance management
CA2782554A1 (en) 2009-12-16 2011-07-14 Dow Agrosciences Llc Modified cry1ca insecticidal cry proteins
CA3049609C (en) * 2010-02-18 2024-02-13 Athenix Corp. Axmi221z, axmi222z, axmi223z, axmi224z, and axmi225z delta-endotoxin genes and methods for their use
US8735560B1 (en) * 2010-03-02 2014-05-27 Monsanto Technology Llc Multiple domain lepidopteran active toxin proteins
WO2011133892A1 (en) * 2010-04-23 2011-10-27 Dow Agrosciences Llc Combinations including cry34ab/35ab and cry3ba proteins to prevent development of resistance in corn rootworms (diabrotica spp.)
US9234208B1 (en) 2010-05-10 2016-01-12 Dow Agrosciences Llc DIG-13 insecticidal cry toxins
UA111592C2 (uk) * 2010-07-07 2016-05-25 Сінгента Партісіпейшнс Аг Спосіб контролю над твердокрилими комахами-шкідниками
WO2012083219A1 (en) * 2010-12-16 2012-06-21 Dow Agrosciences Llc Combined use of vip3ab and cry1ab for management of resistance insects
WO2012131619A1 (en) * 2011-03-30 2012-10-04 Metahelix Life Sciences Limited A nucleotide sequence, expression cassette, transgenic events, cells and methods thereof
US10119149B2 (en) 2011-08-05 2018-11-06 Dow Agrosciences Llc Use of DIG3 insecticidal crystal protein in combination with cry1Ab for management of resistance in european cornborer
MX2014001456A (es) * 2011-08-05 2014-02-27 Dow Agrosciences Llc Uso de proteina cristalina insecticida dig3 en combinacion con cry1ab.
CN103923204B (zh) * 2014-04-04 2016-06-08 湖北省生物农药工程研究中心 杀南方根结线虫的苏云金芽胞杆菌的活性物质及其应用
SG10201913870RA (en) 2014-10-16 2020-03-30 Monsanto Technology Llc Novel chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests
US10487123B2 (en) 2014-10-16 2019-11-26 Monsanto Technology Llc Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests
TW201615095A (zh) 2014-10-31 2016-05-01 陶氏農業科學公司 Ｄｉｇ－３０３殺蟲ｃｒｙ毒素
CN114213510A (zh) 2014-12-30 2022-03-22 美国陶氏益农公司 可用于控制昆虫害虫的修饰的Cry1Ca毒素
CN109952024B (zh) * 2016-10-10 2023-11-03 孟山都技术公司 新型昆虫抑制蛋白
US11692013B2 (en) 2016-10-19 2023-07-04 Pioneer Hi-Bred International, Inc. Broad spectrum insecticidal polypeptide against lepidopteran pests and methods of use thereof
CA3037371A1 (en) * 2016-10-19 2018-04-26 Pioneer Hi-Bred International, Inc. Broad spectrum insecticidal polypeptide against lepidopteran pests and methods of use thereof
CN111465406A (zh) 2017-12-15 2020-07-28 先正达参股股份有限公司 用于检测靶蛋白的非抗体配体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341092C (en) 1985-12-12 2000-09-05 David L. Edwards Process for altering the host range of bacillus thuringiensis toxins, and novel toxins produced thereby
IT1231157B (it) * 1989-07-20 1991-11-19 Crc Ricerca Chim Nuovi geni ibridi funzionali di bacillus thuringiensis ottenuti mediante ricombinazione in vivo.
HU220773B1 (hu) * 1990-01-22 2002-05-28 Dekalb Genetics Corporation Eljárás termő transzgenikus kukoricanövények előállítására
GB9318207D0 (en) 1993-09-02 1993-10-20 Sandoz Ltd Improvements in or relating to organic compounds
US5593881A (en) * 1994-05-06 1997-01-14 Mycogen Corporation Bacillus thuringiensis delta-endotoxin
US5527883A (en) 1994-05-06 1996-06-18 Mycogen Corporation Delta-endotoxin expression in pseudomonas fluorescens
US5508264A (en) 1994-12-06 1996-04-16 Mycogen Corporation Pesticidal compositions

Also Published As

Publication number Publication date
IL110829A0 (en) 1994-11-11
PL181408B1 (pl) 2001-07-31
PL313317A1 (en) 1996-06-24
DE69434758T2 (de) 2006-11-09
RU2210593C2 (ru) 2003-08-20
DE69434758D1 (de) 2006-07-20
UA57698C2 (uk) 2003-07-15
BR9407377A (pt) 1996-07-16
CA2168011C (en) 2007-11-06
CA2168011A1 (en) 1995-03-09
EP0719335A1 (en) 1996-07-03
EP0719335B1 (en) 2006-06-07
TW430669B (en) 2001-04-21
KR100360918B1 (ko) 2005-01-15
ES2262136T3 (es) 2006-11-16
GB9318207D0 (en) 1993-10-20
WO1995006730A1 (en) 1995-03-09
AU691522B2 (en) 1998-05-21
US6204246B1 (en) 2001-03-20
ATE329033T1 (de) 2006-06-15
IL110829A (en) 2006-08-20
JPH09502343A (ja) 1997-03-11
US5736131A (en) 1998-04-07
AU7693294A (en) 1995-03-22

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