ZA946673B - Bisconjugates comrpising two saccharides and a spacer. - Google Patents

Bisconjugates comrpising two saccharides and a spacer.

Info

Publication number
ZA946673B
ZA946673B ZA946673A ZA946673A ZA946673B ZA 946673 B ZA946673 B ZA 946673B ZA 946673 A ZA946673 A ZA 946673A ZA 946673 A ZA946673 A ZA 946673A ZA 946673 B ZA946673 B ZA 946673B
Authority
ZA
South Africa
Prior art keywords
spacer
saccharides
bisconjugates
comrpising
saccharide
Prior art date
Application number
ZA946673A
Other languages
English (en)
Inventor
Constant Adriaan Anton Boeckel
Peter Diederik Jan Grootenhuis
Maurice Petitou
Original Assignee
Akzo Nobel Nv
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Sanofi Elf filed Critical Akzo Nobel Nv
Publication of ZA946673B publication Critical patent/ZA946673B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA946673A 1993-09-01 1994-08-31 Bisconjugates comrpising two saccharides and a spacer. ZA946673B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93202562 1993-09-01

Publications (1)

Publication Number Publication Date
ZA946673B true ZA946673B (en) 1995-04-21

Family

ID=8214074

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA946673A ZA946673B (en) 1993-09-01 1994-08-31 Bisconjugates comrpising two saccharides and a spacer.

Country Status (20)

Country Link
US (1) US5705489A (no)
EP (1) EP0649854B1 (no)
JP (1) JP3918953B2 (no)
KR (1) KR100365578B1 (no)
AT (1) ATE190619T1 (no)
AU (1) AU679084B2 (no)
BR (1) BR1100612A (no)
CA (1) CA2131229C (no)
DE (1) DE69423414T2 (no)
DK (1) DK0649854T3 (no)
ES (1) ES2147216T3 (no)
FI (1) FI113540B (no)
GR (1) GR3033410T3 (no)
HK (1) HK1002009A1 (no)
HU (1) HU227279B1 (no)
NO (1) NO301984B1 (no)
NZ (1) NZ264340A (no)
PT (1) PT649854E (no)
TW (1) TW349951B (no)
ZA (1) ZA946673B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9201440A (nl) * 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
JP4369052B2 (ja) 1998-06-17 2009-11-18 ナームローゼ・フエンノートチヤツプ・オルガノン 抗血栓症化合物
WO2001012675A1 (fr) * 1999-08-10 2001-02-22 Seikagaku Corporation Derives de glycosaminoglycane et leur utilisation
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
DE10041221A1 (de) * 2000-08-22 2002-03-14 Deutsches Krebsforsch Verfahren zur Herstellung von wasserlöslichen Saccharidkonjugaten und Saccharidmimetika durch Diels-Alder-Reaktion und ihre Verwendung als Therapeutika oder Diagnostika
EP1574516A1 (en) 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
EP1886696A1 (en) * 2006-08-03 2008-02-13 Endotis Pharma Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins
WO2010037180A1 (en) * 2008-10-03 2010-04-08 Glycan Biosciences Pty Ltd Anionic oligosaccharide conjugates
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
JP2013537181A (ja) 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
EP2578594A1 (en) * 2011-10-04 2013-04-10 Sanofi Process of preparation of L-iduronic acid comprising a decarboxylation/intramolecular cyclisation tandem reaction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
EP0347964A1 (en) * 1988-06-21 1989-12-27 Akzo N.V. New oligosaccharides with internal spacer
ES2060284T3 (es) * 1990-04-23 1994-11-16 Sanofi Elf Un procedimiento para la preparacion de un derivado de carbohidrato que comprende una unidad de trisacarido.

Also Published As

Publication number Publication date
FI944001A (fi) 1995-03-02
ATE190619T1 (de) 2000-04-15
BR1100612A (pt) 2003-02-25
AU7161094A (en) 1995-03-16
PT649854E (pt) 2000-07-31
FI944001A0 (fi) 1994-08-31
EP0649854A1 (en) 1995-04-26
JP3918953B2 (ja) 2007-05-23
DK0649854T3 (da) 2000-07-03
TW349951B (en) 1999-01-11
NO943222L (no) 1995-03-02
CA2131229A1 (en) 1995-03-02
GR3033410T3 (en) 2000-09-29
NO301984B1 (no) 1998-01-05
FI113540B (fi) 2004-05-14
HU227279B1 (en) 2011-01-28
DE69423414T2 (de) 2000-09-21
HK1002009A1 (en) 1998-07-24
DE69423414D1 (de) 2000-04-20
CA2131229C (en) 2005-04-12
HUT69163A (en) 1995-08-28
US5705489A (en) 1998-01-06
HU9402514D0 (en) 1994-10-28
JPH07304787A (ja) 1995-11-21
KR950008528A (ko) 1995-04-19
NZ264340A (en) 1995-04-27
KR100365578B1 (ko) 2003-03-19
NO943222D0 (no) 1994-08-31
EP0649854B1 (en) 2000-03-15
ES2147216T3 (es) 2000-09-01
AU679084B2 (en) 1997-06-19

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