DE69423414D1 - Biskonjugate, die zwei Saccharide und einen Spacer enthalten - Google Patents

Biskonjugate, die zwei Saccharide und einen Spacer enthalten

Info

Publication number
DE69423414D1
DE69423414D1 DE69423414T DE69423414T DE69423414D1 DE 69423414 D1 DE69423414 D1 DE 69423414D1 DE 69423414 T DE69423414 T DE 69423414T DE 69423414 T DE69423414 T DE 69423414T DE 69423414 D1 DE69423414 D1 DE 69423414D1
Authority
DE
Germany
Prior art keywords
spacer
saccharides
bisconjugates
saccharide
bisconjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69423414T
Other languages
English (en)
Other versions
DE69423414T2 (de
Inventor
Boeckel Constant Van
Peter Grootenhuis
Maurice Petitou
Pieter Westerduin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA, Akzo Nobel NV filed Critical Sanofi Synthelabo SA
Publication of DE69423414D1 publication Critical patent/DE69423414D1/de
Application granted granted Critical
Publication of DE69423414T2 publication Critical patent/DE69423414T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69423414T 1993-09-01 1994-08-30 Biskonjugate, die zwei Saccharide und einen Spacer enthalten Expired - Lifetime DE69423414T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93202562 1993-09-01

Publications (2)

Publication Number Publication Date
DE69423414D1 true DE69423414D1 (de) 2000-04-20
DE69423414T2 DE69423414T2 (de) 2000-09-21

Family

ID=8214074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69423414T Expired - Lifetime DE69423414T2 (de) 1993-09-01 1994-08-30 Biskonjugate, die zwei Saccharide und einen Spacer enthalten

Country Status (20)

Country Link
US (1) US5705489A (de)
EP (1) EP0649854B1 (de)
JP (1) JP3918953B2 (de)
KR (1) KR100365578B1 (de)
AT (1) ATE190619T1 (de)
AU (1) AU679084B2 (de)
BR (1) BR1100612A (de)
CA (1) CA2131229C (de)
DE (1) DE69423414T2 (de)
DK (1) DK0649854T3 (de)
ES (1) ES2147216T3 (de)
FI (1) FI113540B (de)
GR (1) GR3033410T3 (de)
HK (1) HK1002009A1 (de)
HU (1) HU227279B1 (de)
NO (1) NO301984B1 (de)
NZ (1) NZ264340A (de)
PT (1) PT649854E (de)
TW (1) TW349951B (de)
ZA (1) ZA946673B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9201440A (nl) * 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
DE69939378D1 (de) * 1998-06-17 2008-10-02 Organon Nv Antithrombotische verbindungen
AU6472900A (en) * 1999-08-10 2001-03-13 Seikagaku Corporation Glycosaminoglycan derivatives and utilization thereof
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
DE10041221A1 (de) * 2000-08-22 2002-03-14 Deutsches Krebsforsch Verfahren zur Herstellung von wasserlöslichen Saccharidkonjugaten und Saccharidmimetika durch Diels-Alder-Reaktion und ihre Verwendung als Therapeutika oder Diagnostika
EP1574516A1 (de) 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotische Verbindungen
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
EP1886696A1 (de) * 2006-08-03 2008-02-13 Endotis Pharma Konjugate von antithrombin-bindende-oligosaccharid-derivate und therapeutische proteine
US8597632B2 (en) 2008-10-03 2013-12-03 Glycan Biosciences Llc Anionic oligosaccharide conjugates
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
JP2013537181A (ja) 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
EP2578594A1 (de) * 2011-10-04 2013-04-10 Sanofi Verfahren zur Herstellung von L-Iduronsäure mittels einer Decarboxylierung/intramolekulare Zyklisierungs-Tandemreaktion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
EP0347964A1 (de) * 1988-06-21 1989-12-27 Akzo N.V. Oligosaccharide mit interner Nichtsaccharid-Brücke
IE64378B1 (en) * 1990-04-23 1995-07-26 Akzo Nv Carbohydrate derivatives comprising a trisaccharide unit

Also Published As

Publication number Publication date
ZA946673B (en) 1995-04-21
HU227279B1 (en) 2011-01-28
KR950008528A (ko) 1995-04-19
FI113540B (fi) 2004-05-14
DK0649854T3 (da) 2000-07-03
ATE190619T1 (de) 2000-04-15
ES2147216T3 (es) 2000-09-01
HUT69163A (en) 1995-08-28
US5705489A (en) 1998-01-06
FI944001A0 (fi) 1994-08-31
TW349951B (en) 1999-01-11
FI944001A (fi) 1995-03-02
HU9402514D0 (en) 1994-10-28
HK1002009A1 (en) 1998-07-24
NO943222D0 (no) 1994-08-31
CA2131229A1 (en) 1995-03-02
NZ264340A (en) 1995-04-27
JP3918953B2 (ja) 2007-05-23
NO943222L (no) 1995-03-02
JPH07304787A (ja) 1995-11-21
BR1100612A (pt) 2003-02-25
GR3033410T3 (en) 2000-09-29
PT649854E (pt) 2000-07-31
EP0649854B1 (de) 2000-03-15
CA2131229C (en) 2005-04-12
AU7161094A (en) 1995-03-16
EP0649854A1 (de) 1995-04-26
KR100365578B1 (ko) 2003-03-19
NO301984B1 (no) 1998-01-05
AU679084B2 (en) 1997-06-19
DE69423414T2 (de) 2000-09-21

Similar Documents

Publication Publication Date Title
DE69423414D1 (de) Biskonjugate, die zwei Saccharide und einen Spacer enthalten
ATE148712T1 (de) Zusammensetzung von hydrierten sacchariden, die die kariesbildung vermindert, verfahren zu ihrer herstellung und ihre anwendung
DE59400536D1 (de) Längenverstellbare Säule für Stühle, Tische od.dgl.
DE59003329D1 (de) Anbauregal od. dgl. Lagervorrichtung, insbesondere für Langgut.
DE59401899D1 (de) Längenverstellbare Säule für Stühle, Tische o.dgl.
DK0960132T3 (da) Polysaccharid, mikroorganisme og fremgangsmåde til fremstilling deraf, præparat med indhold deraf samt anvendelse
DE69109040D1 (de) Verbesserungen bei den nach dem Rasterverfahren arbeitenden Sichtgeräten.
ATA156388A (de) Zapfwellengetriebe, insbesondere für die frontzapfwelle von ackerschleppern od. dgl.
DE69204164T2 (de) Vielstufiges Drehmoment verteilendes Differential.
DE69016165D1 (de) Übertragungsverfahren und -anordnung für hohe Datenraten nach dem asynchronen Mode-Prinzip.
ATA332187A (de) Verstellgestänge für fenster, türen od.dgl.
CA2283457A1 (en) Polyvalent carbohydrate molecules
ITMI930029A1 (it) Procedimento di produzione del sale trisodico ottaidrato cristallino del fruttosio 1, 6-difosfato (fdpna3h*8h20)
DE59205402D1 (de) Längenverstellbare Säule für Tische, Stühle od.dgl.
ITFI930187A0 (it) Disaccaridi di antracicline, loro processi di preparazione e composizione farmaceutiche che li contengono.
World Health Organization Third Interregional Workshop on Health Systems Research, Cuernavaca, Mexico, 27 July to 7 August 1992: report
FR2657242B3 (fr) Presentoir de vente pour chaines, tuyaux et articles analogues.
IT8420764V0 (it) Dispositivo di trazione particolarmente applicabile in senso ortopedico alla colonna vertebrale.
MX9201448A (es) Anticoagulantes y procesos para prepararlos.
TH17897EX (th) บิคอนจูเกตที่ประกอบด้วยแซคคาไรด์สองหน่วยและส่วนคั่น
IT8423888V0 (it) Porta componibile dotata di battuta, montabile con apertura in un senso o in quello opposto.
ES2132787T3 (es) Dispositivo de engranaje de cremallera asistido, sobre todo direccion de cremallera asistida.
ITTO930835A0 (it) Cremagliera, particolarmente per dispositivi di sterzo a rapporto di trasmissione variabile, e procedimento per la sua realizzazione.
ATE103022T1 (de) Druckformierleiste.
RU93035261A (ru) Вещество, обладающее антиагрегатной активностью

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

R082 Change of representative

Ref document number: 649854

Country of ref document: EP

Representative=s name: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAEL, DE