ZA945689B - Pyrimido pyrimidine compounds - Google Patents
Pyrimido pyrimidine compoundsInfo
- Publication number
- ZA945689B ZA945689B ZA945689A ZA945689A ZA945689B ZA 945689 B ZA945689 B ZA 945689B ZA 945689 A ZA945689 A ZA 945689A ZA 945689 A ZA945689 A ZA 945689A ZA 945689 B ZA945689 B ZA 945689B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrimidine compounds
- pyrimido pyrimidine
- pyrimido
- compounds
- pyrimidine
- Prior art date
Links
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4325900A DE4325900A1 (de) | 1993-08-02 | 1993-08-02 | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA945689B true ZA945689B (en) | 1996-02-01 |
Family
ID=6494272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA945689A ZA945689B (en) | 1993-08-02 | 1994-08-01 | Pyrimido pyrimidine compounds |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5618814A (zh) |
| EP (1) | EP0645390A1 (zh) |
| JP (1) | JPH0789963A (zh) |
| KR (1) | KR950005828A (zh) |
| CN (1) | CN1041091C (zh) |
| AU (1) | AU683888B2 (zh) |
| BG (1) | BG98931A (zh) |
| CA (1) | CA2129179A1 (zh) |
| CZ (1) | CZ184594A3 (zh) |
| DE (1) | DE4325900A1 (zh) |
| EE (1) | EE9400255A (zh) |
| FI (1) | FI943574A (zh) |
| HU (1) | HUT70957A (zh) |
| IL (1) | IL110509A (zh) |
| NO (1) | NO301479B1 (zh) |
| NZ (1) | NZ264133A (zh) |
| PL (1) | PL304512A1 (zh) |
| RO (1) | RO113557B1 (zh) |
| RU (1) | RU94028278A (zh) |
| SK (1) | SK91594A3 (zh) |
| TW (1) | TW251286B (zh) |
| ZA (1) | ZA945689B (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US7618975B2 (en) * | 2003-07-03 | 2009-11-17 | Myriad Pharmaceuticals, Inc. | 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| CN115650827B (zh) * | 2022-10-27 | 2024-03-15 | 戊言医药科技（上海）有限公司 | 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3069211D1 (en) * | 1979-07-03 | 1984-10-25 | Thomae Gmbh Dr K | 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them |
| DE2931573A1 (de) * | 1979-08-03 | 1981-02-26 | Thomae Gmbh Dr K | Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung |
| DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
| DE3423092A1 (de) * | 1984-06-22 | 1986-01-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE3833392A1 (de) * | 1988-10-01 | 1990-04-05 | Thomae Gmbh Dr K | Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel |
-
1993
- 1993-08-02 DE DE4325900A patent/DE4325900A1/de not_active Withdrawn
-
1994
- 1994-07-07 TW TW083106205A patent/TW251286B/zh active
- 1994-07-26 EP EP94111739A patent/EP0645390A1/de not_active Withdrawn
- 1994-07-27 RO RO94-01270A patent/RO113557B1/ro unknown
- 1994-07-28 BG BG98931A patent/BG98931A/bg unknown
- 1994-07-29 NZ NZ264133A patent/NZ264133A/en unknown
- 1994-07-29 SK SK915-94A patent/SK91594A3/sk unknown
- 1994-07-29 IL IL110509A patent/IL110509A/en not_active IP Right Cessation
- 1994-07-29 CA CA002129179A patent/CA2129179A1/en not_active Abandoned
- 1994-08-01 ZA ZA945689A patent/ZA945689B/xx unknown
- 1994-08-01 NO NO942853A patent/NO301479B1/no unknown
- 1994-08-01 KR KR1019940018961A patent/KR950005828A/ko not_active Application Discontinuation
- 1994-08-01 AU AU68813/94A patent/AU683888B2/en not_active Ceased
- 1994-08-01 CN CN94114910A patent/CN1041091C/zh not_active Expired - Fee Related
- 1994-08-01 PL PL94304512A patent/PL304512A1/xx unknown
- 1994-08-01 FI FI943574A patent/FI943574A/fi unknown
- 1994-08-01 HU HU9402253A patent/HUT70957A/hu unknown
- 1994-08-01 JP JP6179359A patent/JPH0789963A/ja active Pending
- 1994-08-01 RU RU94028278/04A patent/RU94028278A/ru unknown
- 1994-08-02 CZ CZ941845A patent/CZ184594A3/cs unknown
- 1994-08-02 US US08/284,325 patent/US5618814A/en not_active Expired - Fee Related
- 1994-11-23 EE EE9400255A patent/EE9400255A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR950005828A (ko) | 1995-03-20 |
| NO942853D0 (zh) | 1994-08-01 |
| FI943574A0 (fi) | 1994-08-01 |
| NZ264133A (en) | 1996-05-28 |
| AU6881394A (en) | 1995-02-09 |
| CA2129179A1 (en) | 1995-02-03 |
| FI943574A (fi) | 1995-02-03 |
| NO942853L (no) | 1995-02-03 |
| RO113557B1 (ro) | 1998-08-28 |
| SK91594A3 (en) | 1995-04-12 |
| IL110509A0 (en) | 1994-10-21 |
| IL110509A (en) | 1998-01-04 |
| AU683888B2 (en) | 1997-11-27 |
| NO301479B1 (no) | 1997-11-03 |
| DE4325900A1 (de) | 1995-02-09 |
| PL304512A1 (en) | 1995-02-06 |
| US5618814A (en) | 1997-04-08 |
| EP0645390A1 (de) | 1995-03-29 |
| EE9400255A (et) | 1996-02-15 |
| TW251286B (zh) | 1995-07-11 |
| HU9402253D0 (en) | 1994-09-28 |
| RU94028278A (ru) | 1996-08-27 |
| CZ184594A3 (en) | 1995-02-15 |
| CN1106405A (zh) | 1995-08-09 |
| BG98931A (en) | 1995-09-29 |
| HUT70957A (en) | 1995-11-28 |
| JPH0789963A (ja) | 1995-04-04 |
| CN1041091C (zh) | 1998-12-09 |
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