ZA945436B - Motilin-like polypeptides with gastrointestinal motor stimulating activity - Google Patents

Motilin-like polypeptides with gastrointestinal motor stimulating activity

Info

Publication number
ZA945436B
ZA945436B ZA945436A ZA945436A ZA945436B ZA 945436 B ZA945436 B ZA 945436B ZA 945436 A ZA945436 A ZA 945436A ZA 945436 A ZA945436 A ZA 945436A ZA 945436 B ZA945436 B ZA 945436B
Authority
ZA
South Africa
Prior art keywords
glu
leu
lys
gln
arg
Prior art date
Application number
ZA945436A
Other languages
English (en)
Inventor
Mark J Macielag
Ramalinga Dharanipragada
James R Florance
Mary Sue Marvin
Alphonse Galdes
Original Assignee
Ohmeda Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohmeda Pharma Prod filed Critical Ohmeda Pharma Prod
Publication of ZA945436B publication Critical patent/ZA945436B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/63—Motilins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
ZA945436A 1993-08-06 1994-07-22 Motilin-like polypeptides with gastrointestinal motor stimulating activity ZA945436B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/103,490 US5422341A (en) 1993-08-06 1993-08-06 Motilin-like polypeptides with gastrointestinal motor stimulating activity

Publications (1)

Publication Number Publication Date
ZA945436B true ZA945436B (en) 1995-04-04

Family

ID=22295474

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA945436A ZA945436B (en) 1993-08-06 1994-07-22 Motilin-like polypeptides with gastrointestinal motor stimulating activity

Country Status (15)

Country Link
US (1) US5422341A (ko)
EP (1) EP0646601B1 (ko)
JP (1) JP2949129B2 (ko)
KR (1) KR100360975B1 (ko)
CN (1) CN1054857C (ko)
AT (1) ATE194627T1 (ko)
AU (1) AU677324B2 (ko)
CA (1) CA2127330C (ko)
DE (1) DE69425212T2 (ko)
DK (1) DK0646601T3 (ko)
ES (1) ES2152293T3 (ko)
FI (1) FI111462B (ko)
NO (1) NO312299B1 (ko)
TW (1) TW434261B (ko)
ZA (1) ZA945436B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5734012A (en) * 1996-05-16 1998-03-31 Ohmeda Pharmaceutical Products Division Inc. Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity
IL140993A0 (en) * 2000-05-15 2002-02-10 Bayer Ag Trypsin substrate and diagnostic device, and method of using same
US20050009205A1 (en) * 2003-07-11 2005-01-13 Ye Fang Fluorescent ligands for GPCR arrays
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬
US20060287243A1 (en) * 2005-06-17 2006-12-21 Navneet Puri Stable pharmaceutical compositions including motilin-like peptides
US20060293243A1 (en) * 2005-06-17 2006-12-28 Navneet Puri Stable, buffered, pharmaceutical compositions including motilin-like peptides
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
EP2460826B1 (en) * 2009-07-29 2017-10-18 Daiichi Sankyo Company, Limited Motilin-like peptide compound having transmucosal absorbability imparted thereto
CN107383169A (zh) * 2017-04-24 2017-11-24 青岛大学 一种具有胃肠运动刺激活性的多肽

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2753274B2 (ja) * 1988-08-24 1998-05-18 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド
EP0378078A1 (en) * 1989-01-06 1990-07-18 Sanwa Kagaku Kenkyusho Co., Ltd. Motilin-like polypeptide and use thereof
JPH02311495A (ja) * 1989-05-24 1990-12-27 Sanwa Kagaku Kenkyusho Co Ltd モチリン様活性を有するポリペプチド及びその用途
JPH04364131A (ja) * 1991-04-03 1992-12-16 Sanwa Kagaku Kenkyusho Co Ltd 易吸収性モチリン製剤

Also Published As

Publication number Publication date
TW434261B (en) 2001-05-16
NO942690L (no) 1995-02-07
AU6596794A (en) 1995-02-16
NO312299B1 (no) 2002-04-22
FI943651A (fi) 1995-02-07
CA2127330C (en) 1998-07-14
KR950005320A (ko) 1995-03-20
CN1054857C (zh) 2000-07-26
DK0646601T3 (da) 2000-09-18
US5422341A (en) 1995-06-06
CN1119650A (zh) 1996-04-03
FI111462B (fi) 2003-07-31
JPH0770178A (ja) 1995-03-14
ATE194627T1 (de) 2000-07-15
DE69425212T2 (de) 2001-03-08
FI943651A0 (fi) 1994-08-05
NO942690D0 (no) 1994-07-18
AU677324B2 (en) 1997-04-17
EP0646601A1 (en) 1995-04-05
CA2127330A1 (en) 1995-02-07
JP2949129B2 (ja) 1999-09-13
DE69425212D1 (de) 2000-08-17
EP0646601B1 (en) 2000-07-12
KR100360975B1 (ko) 2003-01-24
ES2152293T3 (es) 2001-02-01

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