DE69425212D1 - Dem Motilin ähnliche Polypeptide mit stimulierender Wirkung auf den gastrointestinalen Trakt - Google Patents

Dem Motilin ähnliche Polypeptide mit stimulierender Wirkung auf den gastrointestinalen Trakt

Info

Publication number
DE69425212D1
DE69425212D1 DE69425212T DE69425212T DE69425212D1 DE 69425212 D1 DE69425212 D1 DE 69425212D1 DE 69425212 T DE69425212 T DE 69425212T DE 69425212 T DE69425212 T DE 69425212T DE 69425212 D1 DE69425212 D1 DE 69425212D1
Authority
DE
Germany
Prior art keywords
glu
leu
lys
gln
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69425212T
Other languages
English (en)
Other versions
DE69425212T2 (de
Inventor
Mark J Macielag
Ramalinga Dharanipragada
James R Florance
Mary Sue Marvin
Alphonse Galdes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of DE69425212D1 publication Critical patent/DE69425212D1/de
Publication of DE69425212T2 publication Critical patent/DE69425212T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/63—Motilins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE69425212T 1993-08-06 1994-08-01 Dem Motilin ähnliche Polypeptide mit stimulierender Wirkung auf den gastrointestinalen Trakt Expired - Lifetime DE69425212T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/103,490 US5422341A (en) 1993-08-06 1993-08-06 Motilin-like polypeptides with gastrointestinal motor stimulating activity

Publications (2)

Publication Number Publication Date
DE69425212D1 true DE69425212D1 (de) 2000-08-17
DE69425212T2 DE69425212T2 (de) 2001-03-08

Family

ID=22295474

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425212T Expired - Lifetime DE69425212T2 (de) 1993-08-06 1994-08-01 Dem Motilin ähnliche Polypeptide mit stimulierender Wirkung auf den gastrointestinalen Trakt

Country Status (15)

Country Link
US (1) US5422341A (de)
EP (1) EP0646601B1 (de)
JP (1) JP2949129B2 (de)
KR (1) KR100360975B1 (de)
CN (1) CN1054857C (de)
AT (1) ATE194627T1 (de)
AU (1) AU677324B2 (de)
CA (1) CA2127330C (de)
DE (1) DE69425212T2 (de)
DK (1) DK0646601T3 (de)
ES (1) ES2152293T3 (de)
FI (1) FI111462B (de)
NO (1) NO312299B1 (de)
TW (1) TW434261B (de)
ZA (1) ZA945436B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5734012A (en) * 1996-05-16 1998-03-31 Ohmeda Pharmaceutical Products Division Inc. Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity
IL140993A0 (en) * 2000-05-15 2002-02-10 Bayer Ag Trypsin substrate and diagnostic device, and method of using same
US20050009205A1 (en) * 2003-07-11 2005-01-13 Ye Fang Fluorescent ligands for GPCR arrays
US7521420B2 (en) 2003-06-18 2009-04-21 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
US20060293243A1 (en) * 2005-06-17 2006-12-28 Navneet Puri Stable, buffered, pharmaceutical compositions including motilin-like peptides
US20060287243A1 (en) * 2005-06-17 2006-12-21 Navneet Puri Stable pharmaceutical compositions including motilin-like peptides
JP5684474B2 (ja) 2006-09-11 2015-03-11 オセラ セラピューティクス， インコーポレイテッド 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
AU2010279076B2 (en) * 2009-07-29 2014-09-25 Daiichi Sankyo Company,Limited Motilin-like peptide compound having transmucosal absorbability imparted thereto
CN107383169A (zh) * 2017-04-24 2017-11-24 青岛大学 一种具有胃肠运动刺激活性的多肽

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2753274B2 (ja) * 1988-08-24 1998-05-18 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド
EP0378078A1 (de) * 1989-01-06 1990-07-18 Sanwa Kagaku Kenkyusho Co., Ltd. Dem Motilin ähnliches Polypeptid und seine Verwendung
JPH02311495A (ja) * 1989-05-24 1990-12-27 Sanwa Kagaku Kenkyusho Co Ltd モチリン様活性を有するポリペプチド及びその用途
JPH04364131A (ja) * 1991-04-03 1992-12-16 Sanwa Kagaku Kenkyusho Co Ltd 易吸収性モチリン製剤

Also Published As

Publication number Publication date
CN1054857C (zh) 2000-07-26
DK0646601T3 (da) 2000-09-18
ATE194627T1 (de) 2000-07-15
CA2127330A1 (en) 1995-02-07
JP2949129B2 (ja) 1999-09-13
NO942690D0 (no) 1994-07-18
US5422341A (en) 1995-06-06
FI943651A0 (fi) 1994-08-05
CN1119650A (zh) 1996-04-03
JPH0770178A (ja) 1995-03-14
FI111462B (fi) 2003-07-31
EP0646601A1 (de) 1995-04-05
FI943651A (fi) 1995-02-07
AU677324B2 (en) 1997-04-17
ES2152293T3 (es) 2001-02-01
DE69425212T2 (de) 2001-03-08
CA2127330C (en) 1998-07-14
ZA945436B (en) 1995-04-04
KR100360975B1 (ko) 2003-01-24
AU6596794A (en) 1995-02-16
KR950005320A (ko) 1995-03-20
TW434261B (en) 2001-05-16
NO312299B1 (no) 2002-04-22
NO942690L (no) 1995-02-07
EP0646601B1 (de) 2000-07-12

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