ZA935894B - 7-(substituted)-9-((substituted glycyl)amido)-6-demethyl-6-deoxytetracyclines - Google Patents
7-(substituted)-9-((substituted glycyl)amido)-6-demethyl-6-deoxytetracyclinesInfo
- Publication number
- ZA935894B ZA935894B ZA935894A ZA935894A ZA935894B ZA 935894 B ZA935894 B ZA 935894B ZA 935894 A ZA935894 A ZA 935894A ZA 935894 A ZA935894 A ZA 935894A ZA 935894 B ZA935894 B ZA 935894B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted
- deoxytetracyclines
- demethyl
- amido
- glycyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/30—Nitrogen atoms non-acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Seasonings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Moulding By Coating Moulds (AREA)
- Spinning Or Twisting Of Yarns (AREA)
- Fats And Perfumes (AREA)
- Detergent Compositions (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/928,589 US5328902A (en) | 1992-08-13 | 1992-08-13 | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA935894B true ZA935894B (en) | 1994-03-09 |
Family
ID=25456485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA935894A ZA935894B (en) | 1992-08-13 | 1993-08-12 | 7-(substituted)-9-((substituted glycyl)amido)-6-demethyl-6-deoxytetracyclines |
Country Status (26)
Country | Link |
---|---|
US (5) | US5328902A (de) |
EP (1) | EP0582788B1 (de) |
JP (1) | JP3583449B2 (de) |
KR (1) | KR100309539B1 (de) |
CN (1) | CN1034216C (de) |
AT (1) | ATE168992T1 (de) |
AU (1) | AU674690B2 (de) |
CA (1) | CA2103836C (de) |
CZ (1) | CZ288152B6 (de) |
DE (1) | DE69319976T2 (de) |
DK (1) | DK0582788T3 (de) |
ES (1) | ES2119831T3 (de) |
FI (1) | FI115523B (de) |
HK (1) | HK1009598A1 (de) |
HU (2) | HUT64943A (de) |
IL (3) | IL119118A (de) |
LV (1) | LV12358B (de) |
MX (1) | MX9304647A (de) |
NO (1) | NO302359B1 (de) |
NZ (1) | NZ248357A (de) |
PH (1) | PH30007A (de) |
PL (3) | PL174116B1 (de) |
RU (1) | RU2125986C1 (de) |
SG (1) | SG47559A1 (de) |
SK (1) | SK281705B6 (de) |
ZA (1) | ZA935894B (de) |
Families Citing this family (67)
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US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
AU1279095A (en) * | 1994-02-17 | 1995-09-04 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
IL137445A0 (en) * | 1998-01-23 | 2001-07-24 | Tufts College | Pharmaceutically active compounds and methods of use thereof |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6946118B1 (en) | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
JP5093953B2 (ja) * | 1999-09-14 | 2012-12-12 | トラスティーズ オブ タフツ カレッジ | 遷移金属を用いた化学反応による置換テトラサイクリンの調製方法 |
AR033361A1 (es) * | 2000-03-31 | 2003-12-17 | Tufts College | Compuestos de tetraciclina 7- y/o 9- sustituidos y las correspondientes composiciones farmaceuticas, metodos para sintesis e intermediarios reactivos y metodos para tratar estados sensibles a la tetraciclina en mamiferos |
WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
EP2289871A1 (de) * | 2000-07-07 | 2011-03-02 | Paratek Pharmaceuticals, Inc. | 7-substituierte tetracyclinverbindungen |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
EP1679305B1 (de) | 2000-07-07 | 2012-02-08 | Trustees Of Tufts College | 9-substituierte Minocyclinverbindungen |
US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EP1241160A1 (de) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
DE60135387D1 (de) * | 2001-03-13 | 2008-09-25 | Paratek Pharm Innc | 7,9 substituierte tetracyclinverbindungen |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
EP1408987B1 (de) | 2001-07-13 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Tetracyclin-verbindungen mit therapeutischen zielaktivitäten |
AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
EP2311796A1 (de) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-Dedimethylamin-Tetracyclinverbindungen |
IL163931A0 (en) * | 2002-03-08 | 2005-12-18 | Paratek Pharm Innc | Amino-methyl substituted tetracyline compounds |
KR101025400B1 (ko) | 2002-03-21 | 2011-03-28 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
US20040029843A1 (en) * | 2002-06-20 | 2004-02-12 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
EP1534300A4 (de) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | 3, 10, und 12a substituierte tetracyclin-verbindungen |
DE602004025569D1 (de) | 2003-06-18 | 2010-04-01 | Tranzyme Pharma Inc | Makrozyklische motilin rezeptorantagonisten |
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EP2949644A3 (de) | 2004-10-25 | 2016-04-20 | Paratek Pharmaceuticals, Inc. | Substituierte tetracyclin-verbindungen |
EP1805134B1 (de) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracycline und verfahren zu ihrer verwendung |
US7534766B2 (en) | 2004-11-05 | 2009-05-19 | Wyeth | Glucuronide metabolites and epimers thereof of tigecycline |
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AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
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US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
PT2016045E (pt) * | 2006-04-24 | 2015-02-05 | Teva Pharma | Forma cristalina de tigeciclina e processos para a sua preparação |
EP2029749A2 (de) | 2006-05-15 | 2009-03-04 | Paratek Pharmaceuticals, Inc. | Verfahren zur regulierung der expression von genen oder genprodukten mittels substituierter tetracyclinverbindungen |
AR061485A1 (es) * | 2006-06-15 | 2008-08-27 | Serenex Inc | Composiciones estabilizadas de tetraciclina |
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US20080234504A1 (en) * | 2006-11-30 | 2008-09-25 | Evgeny Tsiperman | Processes for preparation of 9-haloacetamidominocyclines |
FR2912133B1 (fr) * | 2007-02-01 | 2009-04-24 | Univ Grenoble 1 | Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens |
EP2114865A1 (de) * | 2007-03-01 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Verfahren zur reinigung von tigecyclin |
US7939513B2 (en) * | 2007-09-07 | 2011-05-10 | Dr. Reddy's Laboratories Limited | Tetracycline derivatives as antibacterial agents |
US8518912B2 (en) | 2007-11-29 | 2013-08-27 | Actelion Pharmaceuticals Ltd. | Phosphonic acid derivates and their use as P2Y12 receptor antagonists |
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US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
US3515731A (en) * | 1966-06-17 | 1970-06-02 | Pfizer & Co C | Antibacterial agents |
US3849493A (en) * | 1966-08-01 | 1974-11-19 | Pfizer | D-ring substituted 6-deoxytetracyclines |
US3345410A (en) * | 1966-12-01 | 1967-10-03 | American Cyanamid Co | Substituted 7- and/or 9-amino tetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
US5281628A (en) * | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
ATE211128T1 (de) * | 1991-10-04 | 2002-01-15 | American Cyanamid Co | 7-substituierte-9-substituierte amino-6-demethyl- 6-deoxy-tetracycline |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
-
1992
- 1992-08-13 US US07/928,589 patent/US5328902A/en not_active Expired - Lifetime
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1993
- 1993-05-12 DE DE69319976T patent/DE69319976T2/de not_active Expired - Fee Related
- 1993-05-12 EP EP93107717A patent/EP0582788B1/de not_active Expired - Lifetime
- 1993-05-12 ES ES93107717T patent/ES2119831T3/es not_active Expired - Lifetime
- 1993-05-12 SG SG1996002832A patent/SG47559A1/en unknown
- 1993-05-12 DK DK93107717T patent/DK0582788T3/da active
- 1993-05-12 AT AT93107717T patent/ATE168992T1/de not_active IP Right Cessation
- 1993-07-01 CN CN93108134A patent/CN1034216C/zh not_active Expired - Fee Related
- 1993-08-02 MX MX9304647A patent/MX9304647A/es not_active IP Right Cessation
- 1993-08-05 CZ CZ19931599A patent/CZ288152B6/cs not_active IP Right Cessation
- 1993-08-09 NZ NZ248357A patent/NZ248357A/en not_active IP Right Cessation
- 1993-08-11 PH PH46666A patent/PH30007A/en unknown
- 1993-08-11 CA CA002103836A patent/CA2103836C/en not_active Expired - Fee Related
- 1993-08-11 JP JP21907393A patent/JP3583449B2/ja not_active Expired - Fee Related
- 1993-08-12 PL PL93300063A patent/PL174116B1/pl not_active IP Right Cessation
- 1993-08-12 IL IL119118A patent/IL119118A/en not_active IP Right Cessation
- 1993-08-12 FI FI933565A patent/FI115523B/fi not_active IP Right Cessation
- 1993-08-12 IL IL106673A patent/IL106673A/xx not_active IP Right Cessation
- 1993-08-12 KR KR1019930015644A patent/KR100309539B1/ko not_active IP Right Cessation
- 1993-08-12 AU AU44612/93A patent/AU674690B2/en not_active Ceased
- 1993-08-12 HU HU9302330A patent/HUT64943A/hu unknown
- 1993-08-12 NO NO932869A patent/NO302359B1/no unknown
- 1993-08-12 PL PL93316753A patent/PL173904B1/pl not_active IP Right Cessation
- 1993-08-12 ZA ZA935894A patent/ZA935894B/xx unknown
- 1993-08-12 PL PL93316752A patent/PL174115B1/pl not_active IP Right Cessation
- 1993-08-12 RU RU93042474A patent/RU2125986C1/ru not_active IP Right Cessation
- 1993-09-08 SK SK856-93A patent/SK281705B6/sk unknown
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1994
- 1994-02-24 US US08/201,306 patent/US5401729A/en not_active Expired - Lifetime
- 1994-03-02 US US08/205,009 patent/US5380888A/en not_active Expired - Lifetime
- 1994-09-12 US US08/304,731 patent/US5466684A/en not_active Expired - Lifetime
- 1994-09-13 US US08/304,913 patent/US5495031A/en not_active Expired - Lifetime
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1995
- 1995-06-30 HU HU95P/P00629P patent/HU211946A9/hu unknown
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1996
- 1996-08-22 IL IL11911896A patent/IL119118A0/xx unknown
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1998
- 1998-09-04 HK HK98110470A patent/HK1009598A1/xx not_active IP Right Cessation
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1999
- 1999-07-26 LV LVP-99-112A patent/LV12358B/en unknown
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