ZA932876B - New peptide derivatives. - Google Patents
New peptide derivatives.Info
- Publication number
- ZA932876B ZA932876B ZA932876A ZA932876A ZA932876B ZA 932876 B ZA932876 B ZA 932876B ZA 932876 A ZA932876 A ZA 932876A ZA 932876 A ZA932876 A ZA 932876A ZA 932876 B ZA932876 B ZA 932876B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- alkyl
- thrombosis
- aralkyl
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929209032A GB9209032D0 (en) | 1992-04-25 | 1992-04-25 | New peptide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA932876B true ZA932876B (en) | 1994-10-19 |
Family
ID=10714598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA932876A ZA932876B (en) | 1992-04-25 | 1993-04-23 | New peptide derivatives. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5686564A (fr) |
EP (1) | EP0637318B1 (fr) |
JP (1) | JPH07505896A (fr) |
KR (1) | KR950701342A (fr) |
AT (1) | ATE164595T1 (fr) |
AU (1) | AU674513B2 (fr) |
CA (1) | CA2133581A1 (fr) |
DE (1) | DE69317772D1 (fr) |
GB (1) | GB9209032D0 (fr) |
IL (1) | IL105510A0 (fr) |
MX (1) | MX9302399A (fr) |
NZ (1) | NZ251709A (fr) |
WO (1) | WO1993022344A1 (fr) |
ZA (1) | ZA932876B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI0788509T1 (en) * | 1993-08-09 | 2003-10-31 | Societe De Conseils De Recherches | Therapeutic peptide derivatives |
ATE198603T1 (de) * | 1993-10-25 | 2001-01-15 | Ca Nat Research Council | Bivalente thrombininhibitore |
GB9426038D0 (en) | 1994-12-22 | 1995-02-22 | Iaf Biochem Int | Low molecular weight bicyclic thrombin inhibitors |
GB9505538D0 (en) * | 1995-03-18 | 1995-05-03 | Ciba Geigy Ag | New compounds |
GB9506212D0 (en) * | 1995-03-27 | 1995-05-17 | Iaf Biochem Int | Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component |
US6057314A (en) * | 1995-12-21 | 2000-05-02 | Biochem Pharma Inc. | Low molecular weight bicyclic thrombin inhibitors |
DE19607239A1 (de) * | 1996-02-27 | 1997-08-28 | Behringwerke Ag | Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung |
ES2351976T3 (es) | 2003-04-29 | 2011-02-14 | Avi Biopharma, Inc. | Composiciones para mejorar el transporte y la eficacia antisentido de análogos de ácidos nucleicos en células. |
CA2536918A1 (fr) | 2003-08-26 | 2005-03-03 | Leland Shapiro | Compositions et procedes pour molecules de fusion fc de l'alpha-1 antitrypsine |
US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
CN102225966B (zh) | 2004-10-19 | 2012-12-26 | 隆萨股份公司 | 用于固相肽合成的方法 |
WO2006121810A2 (fr) * | 2005-05-06 | 2006-11-16 | Providence Health System | Proteine de fusion trimere immunoglobulinique ox-40 et procedes d'utilisation |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
KR102103476B1 (ko) * | 2011-06-24 | 2020-04-23 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
EP2802653A4 (fr) | 2012-01-10 | 2015-09-02 | Univ Colorado Regents | Compositions de molécules de fusion de l'alpha-1 antitrypsine, procédés et utilisations associés |
EP3302489A4 (fr) | 2015-06-04 | 2019-02-06 | Sarepta Therapeutics, Inc. | Procédés et composés pour le traitement de maladies et d'états pathologiques associés aux lymphocytes |
PL3554553T3 (pl) | 2016-12-19 | 2022-11-07 | Sarepta Therapeutics, Inc. | Koniugaty oligomerów z pominięciem egzonu w dystrofii mięśniowej |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4117127A (en) * | 1974-11-08 | 1978-09-26 | Mitsubishi Chemical Industries Ltd. | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
CA1131621A (fr) * | 1977-01-19 | 1982-09-14 | Shosuke Okamoto | N.sup.2-arylsulfonyl-l-argininamides, et leurs sels utilisables en pharmacie |
US4258192A (en) * | 1977-12-16 | 1981-03-24 | Mitsubishi Chemical Industries Limited | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
IE48623B1 (en) * | 1978-08-31 | 1985-03-20 | Mitsubishi Chem Ind | Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances |
FR2628429B1 (fr) * | 1988-03-08 | 1990-12-28 | Transgene Sa | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
HUT57060A (en) * | 1988-12-05 | 1991-11-28 | Biogen Inc | Process for producing compositions for inhibiting blood platelet aggregation |
US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
US5118790A (en) * | 1990-07-24 | 1992-06-02 | Sri International | Analogs of hirudin |
-
1992
- 1992-04-25 GB GB929209032A patent/GB9209032D0/en active Pending
-
1993
- 1993-04-15 EP EP93908944A patent/EP0637318B1/fr not_active Expired - Lifetime
- 1993-04-15 NZ NZ251709A patent/NZ251709A/en unknown
- 1993-04-15 AT AT93908944T patent/ATE164595T1/de active
- 1993-04-15 AU AU39533/93A patent/AU674513B2/en not_active Ceased
- 1993-04-15 US US08/325,253 patent/US5686564A/en not_active Expired - Fee Related
- 1993-04-15 JP JP5518866A patent/JPH07505896A/ja active Pending
- 1993-04-15 KR KR1019940703797A patent/KR950701342A/ko not_active Application Discontinuation
- 1993-04-15 CA CA002133581A patent/CA2133581A1/fr not_active Abandoned
- 1993-04-15 WO PCT/EP1993/000908 patent/WO1993022344A1/fr active IP Right Grant
- 1993-04-15 DE DE69317772T patent/DE69317772D1/de not_active Expired - Lifetime
- 1993-04-23 ZA ZA932876A patent/ZA932876B/xx unknown
- 1993-04-23 IL IL105510A patent/IL105510A0/xx unknown
- 1993-04-23 MX MX9302399A patent/MX9302399A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ATE164595T1 (de) | 1998-04-15 |
AU3953393A (en) | 1993-11-29 |
KR950701342A (ko) | 1995-03-23 |
GB9209032D0 (en) | 1992-06-10 |
EP0637318A1 (fr) | 1995-02-08 |
JPH07505896A (ja) | 1995-06-29 |
IL105510A0 (en) | 1993-08-18 |
EP0637318B1 (fr) | 1998-04-01 |
NZ251709A (en) | 1997-01-29 |
CA2133581A1 (fr) | 1993-11-11 |
AU674513B2 (en) | 1997-01-02 |
US5686564A (en) | 1997-11-11 |
DE69317772D1 (de) | 1998-05-07 |
MX9302399A (es) | 1994-05-31 |
WO1993022344A1 (fr) | 1993-11-11 |
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