ATE164595T1 - Peptidderivate des carboxy-terminalen sequenz von hirudin - Google Patents
Peptidderivate des carboxy-terminalen sequenz von hirudinInfo
- Publication number
- ATE164595T1 ATE164595T1 AT93908944T AT93908944T ATE164595T1 AT E164595 T1 ATE164595 T1 AT E164595T1 AT 93908944 T AT93908944 T AT 93908944T AT 93908944 T AT93908944 T AT 93908944T AT E164595 T1 ATE164595 T1 AT E164595T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- alkyl
- hirudin
- carboxy terminal
- thrombosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929209032A GB9209032D0 (en) | 1992-04-25 | 1992-04-25 | New peptide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164595T1 true ATE164595T1 (de) | 1998-04-15 |
Family
ID=10714598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93908944T ATE164595T1 (de) | 1992-04-25 | 1993-04-15 | Peptidderivate des carboxy-terminalen sequenz von hirudin |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5686564A (de) |
| EP (1) | EP0637318B1 (de) |
| JP (1) | JPH07505896A (de) |
| KR (1) | KR950701342A (de) |
| AT (1) | ATE164595T1 (de) |
| AU (1) | AU674513B2 (de) |
| CA (1) | CA2133581A1 (de) |
| DE (1) | DE69317772D1 (de) |
| GB (1) | GB9209032D0 (de) |
| IL (1) | IL105510A0 (de) |
| MX (1) | MX9302399A (de) |
| NZ (1) | NZ251709A (de) |
| WO (1) | WO1993022344A1 (de) |
| ZA (1) | ZA932876B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1288223E (pt) * | 1993-08-09 | 2005-03-31 | Sod Conseils Rech Applic | Derivados de peptidos terapeuticos |
| ES2153433T3 (es) * | 1993-10-25 | 2001-03-01 | Ca Nat Research Council | Inhibidores de trombina bivalentes. |
| GB9426038D0 (en) | 1994-12-22 | 1995-02-22 | Iaf Biochem Int | Low molecular weight bicyclic thrombin inhibitors |
| GB9505538D0 (en) * | 1995-03-18 | 1995-05-03 | Ciba Geigy Ag | New compounds |
| GB9506212D0 (en) * | 1995-03-27 | 1995-05-17 | Iaf Biochem Int | Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component |
| US6057314A (en) * | 1995-12-21 | 2000-05-02 | Biochem Pharma Inc. | Low molecular weight bicyclic thrombin inhibitors |
| DE19607239A1 (de) * | 1996-02-27 | 1997-08-28 | Behringwerke Ag | Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung |
| DE602004028930D1 (de) | 2003-04-29 | 2010-10-14 | Avi Biopharma Inc | Zusammensetzungen zur verbesserung der antisense-wirksamkeit und des transports von nukleinsäureanalog in zellen |
| US7850970B2 (en) | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| DK1737889T3 (da) | 2004-10-19 | 2011-01-03 | Lonza Ag | Fremgangsmåde til fastfase-peptidsyntese |
| WO2006121810A2 (en) * | 2005-05-06 | 2006-11-16 | Providence Health System | Trimeric ox40-immunoglobulin fusion protein and methods of use |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2012178102A2 (en) * | 2011-06-24 | 2012-12-27 | The Regents Of The Unversity Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| EP2802653A4 (de) | 2012-01-10 | 2015-09-02 | Univ Colorado Regents | Zusammensetzungen, verfahren und verwendung für alpha-1-antitrypsin-fusionsmoleküle |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| PL3554553T3 (pl) | 2016-12-19 | 2022-11-07 | Sarepta Therapeutics, Inc. | Koniugaty oligomerów z pominięciem egzonu w dystrofii mięśniowej |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1131621A (en) * | 1977-01-19 | 1982-09-14 | Shosuke Okamoto | N.sup.2-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof |
| US4117127A (en) * | 1974-11-08 | 1978-09-26 | Mitsubishi Chemical Industries Ltd. | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| US4258192A (en) * | 1977-12-16 | 1981-03-24 | Mitsubishi Chemical Industries Limited | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| IE48623B1 (en) * | 1978-08-31 | 1985-03-20 | Mitsubishi Chem Ind | Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances |
| FR2628429B1 (fr) * | 1988-03-08 | 1990-12-28 | Transgene Sa | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
| US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
| JPH04503660A (ja) * | 1988-12-05 | 1992-07-02 | バイオジェン インコーポレイテッド | 血小板凝集抑制の方法及び組成物 |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| US5118790A (en) * | 1990-07-24 | 1992-06-02 | Sri International | Analogs of hirudin |
-
1992
- 1992-04-25 GB GB929209032A patent/GB9209032D0/en active Pending
-
1993
- 1993-04-15 KR KR1019940703797A patent/KR950701342A/ko not_active Application Discontinuation
- 1993-04-15 CA CA002133581A patent/CA2133581A1/en not_active Abandoned
- 1993-04-15 DE DE69317772T patent/DE69317772D1/de not_active Expired - Lifetime
- 1993-04-15 NZ NZ251709A patent/NZ251709A/en unknown
- 1993-04-15 EP EP93908944A patent/EP0637318B1/de not_active Expired - Lifetime
- 1993-04-15 US US08/325,253 patent/US5686564A/en not_active Expired - Fee Related
- 1993-04-15 JP JP5518866A patent/JPH07505896A/ja active Pending
- 1993-04-15 AT AT93908944T patent/ATE164595T1/de active
- 1993-04-15 AU AU39533/93A patent/AU674513B2/en not_active Ceased
- 1993-04-15 WO PCT/EP1993/000908 patent/WO1993022344A1/en active IP Right Grant
- 1993-04-23 MX MX9302399A patent/MX9302399A/es unknown
- 1993-04-23 IL IL105510A patent/IL105510A0/xx unknown
- 1993-04-23 ZA ZA932876A patent/ZA932876B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69317772D1 (de) | 1998-05-07 |
| MX9302399A (es) | 1994-05-31 |
| EP0637318B1 (de) | 1998-04-01 |
| IL105510A0 (en) | 1993-08-18 |
| NZ251709A (en) | 1997-01-29 |
| WO1993022344A1 (en) | 1993-11-11 |
| ZA932876B (en) | 1994-10-19 |
| JPH07505896A (ja) | 1995-06-29 |
| US5686564A (en) | 1997-11-11 |
| CA2133581A1 (en) | 1993-11-11 |
| EP0637318A1 (de) | 1995-02-08 |
| AU674513B2 (en) | 1997-01-02 |
| AU3953393A (en) | 1993-11-29 |
| GB9209032D0 (en) | 1992-06-10 |
| KR950701342A (ko) | 1995-03-23 |
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