ZA932010B - Process for the preparation of nucleosides - Google Patents
Process for the preparation of nucleosidesInfo
- Publication number
- ZA932010B ZA932010B ZA932010A ZA932010A ZA932010B ZA 932010 B ZA932010 B ZA 932010B ZA 932010 A ZA932010 A ZA 932010A ZA 932010 A ZA932010 A ZA 932010A ZA 932010 B ZA932010 B ZA 932010B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- nucleosides
- base
- oligonucleotides
- nucleoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH90692 | 1992-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA932010B true ZA932010B (en) | 1993-10-13 |
Family
ID=4197933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA932010A ZA932010B (en) | 1992-03-23 | 1993-03-22 | Process for the preparation of nucleosides |
Country Status (12)
Country | Link |
---|---|
US (1) | US5268464A (da) |
EP (1) | EP0563010B1 (da) |
JP (1) | JP4071295B2 (da) |
KR (1) | KR930019688A (da) |
AT (1) | ATE179427T1 (da) |
AU (1) | AU680610B2 (da) |
CA (1) | CA2092038C (da) |
DE (1) | DE59309536D1 (da) |
DK (1) | DK0563010T3 (da) |
ES (1) | ES2130241T3 (da) |
TW (1) | TW323284B (da) |
ZA (1) | ZA932010B (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5386023A (en) * | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
US5610289A (en) * | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
US5955591A (en) * | 1993-05-12 | 1999-09-21 | Imbach; Jean-Louis | Phosphotriester oligonucleotides, amidites and method of preparation |
DK0644196T3 (da) * | 1993-09-17 | 1998-07-27 | Novartis Ag | TTTr som beskyttelsesgruppe i nucleotidsyntesen |
DE4415370A1 (de) * | 1994-05-02 | 1995-11-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
US5990300A (en) * | 1994-09-02 | 1999-11-23 | Andrew C. Hiatt | Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
US6232465B1 (en) | 1994-09-02 | 2001-05-15 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
US5808045A (en) * | 1994-09-02 | 1998-09-15 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
US5872244A (en) * | 1994-09-02 | 1999-02-16 | Andrew C. Hiatt | 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds |
US5763594A (en) * | 1994-09-02 | 1998-06-09 | Andrew C. Hiatt | 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds |
US6214987B1 (en) | 1994-09-02 | 2001-04-10 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides |
US6441150B1 (en) * | 1997-12-16 | 2002-08-27 | Isis Pharmaceuticals, Inc. | Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites |
FR2781229B1 (fr) * | 1998-07-17 | 2001-11-30 | Univ Nice Sophia Antipolis | Nouveaux composes analogues des nucleotides, leurs procedes de preparation et leurs applications |
US6184347B1 (en) | 1998-11-19 | 2001-02-06 | Agilent Technologies Inc. | Minimization of blooming in high-density arrays by using reactive wash reagents |
WO2005070859A1 (ja) * | 2004-01-27 | 2005-08-04 | Takeshi Wada | フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法 |
US7897378B2 (en) * | 2004-03-18 | 2011-03-01 | Roche Molecular Systems, Inc. | Method and device for purifying nucleic acids |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
US8691971B2 (en) | 2008-09-23 | 2014-04-08 | Scott G. Petersen | Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference |
EP2599785A1 (en) * | 2011-11-30 | 2013-06-05 | Agilent Technologies, Inc. | Novel methods for the synthesis and purification of oligomers |
CA2880869A1 (en) | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
AU2017312116A1 (en) | 2016-08-17 | 2019-03-07 | Solstice Biologics, Ltd. | Polynucleotide constructs |
JP2020522510A (ja) * | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | オリゴヌクレオチド組成物及びその使用方法 |
EP3645546A4 (en) | 2017-06-30 | 2021-12-01 | Solstice Biologics, Ltd. | CHIRAL PHOSPHORAMIDITIS AUXILIARIES AND THEIR METHODS OF USE |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE271331C (da) * | 1920-11-12 | |||
JPS5229749A (en) * | 1975-09-02 | 1977-03-05 | Mitsubishi Electric Corp | Optical equipment and its manufacturing process |
SU809866A1 (ru) * | 1979-05-14 | 1982-03-30 | Всесоюзный Научно-Исследовательский Институт Молекулярной Биологии | Способ удалени цианэтильной защитной группы с производных моно-и олигонуклеотидов |
US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
IL62834A0 (en) * | 1980-05-14 | 1981-07-31 | Ens Bio Logicals Inc | Polynucleotide synthesis |
US4373071A (en) * | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
JPS5927900A (ja) * | 1982-08-09 | 1984-02-14 | Wakunaga Seiyaku Kk | 固定化オリゴヌクレオチド |
US4672110A (en) * | 1983-11-29 | 1987-06-09 | Northwestern University | Method of deprotecting polynucleotide trimethylethyl phosphotriesters |
US4849513A (en) * | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US4818681A (en) * | 1985-02-22 | 1989-04-04 | Molecular Diagnostics, Inc. | Fast and specific immobilization of nucleic acids to solid supports |
EP0216357A3 (en) * | 1985-09-25 | 1988-08-31 | Nippon Zeon Co., Ltd. | Phosphoramidite compounds and process for production thereof |
EP0289619B1 (en) * | 1986-10-30 | 1995-08-16 | Daicel Chemical Industries, Ltd. | Process for synthesizing oligonucleotides and compounds for forming high-molecular protective group |
JPH0291088A (ja) * | 1988-09-29 | 1990-03-30 | Central Glass Co Ltd | ホスファイトおよびヌクレオシド‐3’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法 |
FR2651130B1 (fr) * | 1989-08-23 | 1991-12-13 | Roussel Uclaf | Sequence d'oligonucleotides anti-sens, anti-arn message du tnf alpha, procede de preparation, application a titre de medicaments et compositions pharmaceutiques. |
US5042524A (en) * | 1989-09-29 | 1991-08-27 | Metlund Enterprises | Demand recovery hot water system |
US5430138A (en) * | 1990-07-27 | 1995-07-04 | Chiron Corporation | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
-
1993
- 1993-03-12 TW TW082101835A patent/TW323284B/zh active
- 1993-03-15 ES ES93810184T patent/ES2130241T3/es not_active Expired - Lifetime
- 1993-03-15 US US08/031,455 patent/US5268464A/en not_active Expired - Lifetime
- 1993-03-15 AT AT93810184T patent/ATE179427T1/de not_active IP Right Cessation
- 1993-03-15 EP EP93810184A patent/EP0563010B1/de not_active Expired - Lifetime
- 1993-03-15 DK DK93810184T patent/DK0563010T3/da active
- 1993-03-15 DE DE59309536T patent/DE59309536D1/de not_active Expired - Fee Related
- 1993-03-19 CA CA002092038A patent/CA2092038C/en not_active Expired - Fee Related
- 1993-03-22 AU AU35399/93A patent/AU680610B2/en not_active Ceased
- 1993-03-22 ZA ZA932010A patent/ZA932010B/xx unknown
- 1993-03-22 KR KR1019930004388A patent/KR930019688A/ko not_active Application Discontinuation
- 1993-03-23 JP JP06421193A patent/JP4071295B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH069673A (ja) | 1994-01-18 |
AU680610B2 (en) | 1997-08-07 |
KR930019688A (ko) | 1993-10-18 |
EP0563010B1 (de) | 1999-04-28 |
US5268464A (en) | 1993-12-07 |
ES2130241T3 (es) | 1999-07-01 |
DK0563010T3 (da) | 1999-11-08 |
CA2092038A1 (en) | 1993-09-24 |
CA2092038C (en) | 2003-12-16 |
ATE179427T1 (de) | 1999-05-15 |
EP0563010A2 (de) | 1993-09-29 |
EP0563010A3 (en) | 1994-09-14 |
DE59309536D1 (de) | 1999-06-02 |
AU3539993A (en) | 1993-09-30 |
TW323284B (da) | 1997-12-21 |
JP4071295B2 (ja) | 2008-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU680610B2 (en) | Process for the preparation of nucleosides | |
CA2159710A1 (en) | Organosilicon-Containing Materials Useful for Biomedical Devices | |
DE69533358D1 (de) | Härtbare zusammensetzungen | |
DK387889D0 (da) | Makrolider, og farmaceutiske praeparater med indhold af saadanne forbindelser | |
DE69416306D1 (de) | Sphingoglycolipid und verwendung davon | |
ES8405398A1 (es) | Procedimiento para preparar nuevos diazabiciclo-(3.3.1)-nonanos | |
GB2148900B (en) | Curable compositions | |
EP0394496A4 (en) | Glycoside derivatives, polymers containing glycoside derivatives, process for their preparation, and use of said polymers | |
CA2183040A1 (en) | Dental or surgical adhesive and polymerization initiator composition for the same | |
ZA891114B (en) | Stabilizing composition for organic polymers | |
ES2092116T3 (es) | Policarbonatos y sus usos para la preparacion de matrices bioerosionables. | |
SE8703032D0 (da) | ||
JPS5562963A (en) | Photo-setting organopolysiloxane composition | |
EP0206544A3 (en) | Instantaneously curable composition | |
EP0298336B1 (en) | Aromatic polyisocyanates, process for their preparation and their use as components of adhesives | |
DE69018730D1 (de) | Oxazolopyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen. | |
TW198053B (da) | ||
GB2044614B (en) | Therapeutic compositions with a cytostatic action | |
JPS53118453A (en) | Curable organopolysiloxane composition | |
GB9715709D0 (en) | Novel compounds | |
JPS5223144A (en) | Polymer composition stabilised against ultraviolet rays | |
IL87478A0 (en) | Preparation of dien-1-ols,9-hydroxydodec-10-enyl 1-tert-butyl ether and use thereof as an intermediate for synthesizing 8,10-dodecadienol | |
PH18551A (en) | Fluorophenoxybenzyl esters and the composition containing same | |
JPS5448842A (en) | Method of preventing yellowing of thermoplastic polymer composition | |
EP0288771A3 (en) | Protective helmets consisting of composite materials essentially based on a polyisocyanuric matrix |