ZA925663B - Compounds and methods for inhibition of HIV and related viruses - Google Patents
Compounds and methods for inhibition of HIV and related virusesInfo
- Publication number
- ZA925663B ZA925663B ZA925663A ZA925663A ZA925663B ZA 925663 B ZA925663 B ZA 925663B ZA 925663 A ZA925663 A ZA 925663A ZA 925663 A ZA925663 A ZA 925663A ZA 925663 B ZA925663 B ZA 925663B
- Authority
- ZA
- South Africa
- Prior art keywords
- hiv
- inhibition
- compounds
- methods
- related viruses
- Prior art date
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
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- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US73992791A | 1991-08-02 | 1991-08-02 |
Publications (1)
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ZA925663B true ZA925663B (en) | 1994-01-28 |
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ZA925663A ZA925663B (en) | 1991-08-02 | 1992-07-28 | Compounds and methods for inhibition of HIV and related viruses |
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EP (1) | EP0540143B1 (ko) |
JP (1) | JP3383328B2 (ko) |
KR (1) | KR100252453B1 (ko) |
CN (1) | CN1069882A (ko) |
AP (2) | AP384A (ko) |
AT (1) | ATE232095T1 (ko) |
AU (2) | AU657978B2 (ko) |
BG (1) | BG98623A (ko) |
CA (1) | CA2075173C (ko) |
CZ (1) | CZ282900B6 (ko) |
DE (1) | DE69232919T2 (ko) |
ES (1) | ES2051641B1 (ko) |
FI (1) | FI923443A (ko) |
HU (2) | HU9202477D0 (ko) |
IL (1) | IL102548A (ko) |
MX (1) | MX9204454A (ko) |
NO (1) | NO922949L (ko) |
OA (1) | OA09914A (ko) |
RU (1) | RU2106341C1 (ko) |
TW (1) | TW252110B (ko) |
WO (1) | WO1993003022A1 (ko) |
YU (1) | YU74292A (ko) |
ZA (1) | ZA925663B (ko) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
DK0706514T3 (da) * | 1993-08-24 | 1999-08-02 | Medivir Ab | Forbindelser og fremgangsmåder til inhibering af HIV og relaterede vira |
WO1997041846A1 (en) * | 1996-05-06 | 1997-11-13 | Eli Lilly And Company | Anti-viral compounds |
DE69704180T2 (de) | 1996-05-06 | 2001-08-30 | Eli Lilly And Co., Indianapolis | Antivirusverbindungen |
AU2752297A (en) * | 1996-05-06 | 1997-11-26 | Eli Lilly And Company | Anti-viral compounds |
US6103923A (en) * | 1996-05-06 | 2000-08-15 | Eli Lilly And Company | Anti-viral compounds |
AU2752597A (en) * | 1996-05-06 | 1997-11-26 | Eli Lilly And Company | Anti-viral compounds |
US6156924A (en) * | 1996-05-06 | 2000-12-05 | Eli Lilly And Company | Anti-viral compounds |
US6127422A (en) * | 1996-05-06 | 2000-10-03 | Eli Lilly And Company | Anti-viral method |
US6096917A (en) * | 1997-05-02 | 2000-08-01 | Eli Lilly And Company | Anti-viral compounds |
US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
US6136335A (en) | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
US7186736B1 (en) * | 1999-03-20 | 2007-03-06 | Parker Hughes Institute | NNI for treatment of multi-drug resistant HIV |
US6245788B1 (en) | 1999-03-31 | 2001-06-12 | The Procter & Gamble Company | Viral treatment |
US6258831B1 (en) | 1999-03-31 | 2001-07-10 | The Procter & Gamble Company | Viral treatment |
US6340696B1 (en) | 1999-03-31 | 2002-01-22 | The Procter & Gamble Company | Viral treatment |
US6124324A (en) * | 1999-06-23 | 2000-09-26 | Hughes Institute | Thiophene-ethyl thiourea compounds and use |
US6207688B1 (en) * | 1999-06-23 | 2001-03-27 | Parker Hughes Institute | Phenethyl-thiourea compounds and use |
US6469034B1 (en) | 1999-06-23 | 2002-10-22 | Parker Hughes Institute | Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase |
GB2361473C (en) * | 2000-03-08 | 2005-06-28 | Microgenics Corp | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds |
US6175034B1 (en) | 2000-04-10 | 2001-01-16 | Eli Lilly And Company | Anti-viral compounds |
US6774139B1 (en) | 2000-06-30 | 2004-08-10 | Parker Hughes Institute | Dual function microbicides |
US6545152B1 (en) | 2000-07-18 | 2003-04-08 | Parker Hughes Institute | R-isomers of nonnucleoside inhibitors |
AU2001221154A1 (en) * | 2000-10-19 | 2002-04-29 | Parker Hughes Institute | Aromatic and heterocyclic thiazolyl thiourea compounds and use |
US6689793B2 (en) | 2000-12-06 | 2004-02-10 | Parker Hughes Institute | Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity |
SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
SE0102867D0 (sv) | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
SI2287155T1 (sl) * | 2008-04-10 | 2013-10-30 | Taiho Pharmaceutical Co., Ltd. | Aciltiosečninska spojina ali njena sol in njena uporaba |
KR101064258B1 (ko) * | 2008-12-29 | 2011-09-14 | 한국과학기술연구원 | 벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환예방 또는 치료용 조성물 |
RS57025B1 (sr) * | 2013-07-08 | 2018-05-31 | Syngenta Participations Ag | 4-očlani prstenovi karboksamida koji se koriste kao nematicidi |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA689412A (en) * | 1964-06-23 | Berger Arthur | Preparation of 3-allyl-5-isobutyl-2-thiohydantoin | |
US3061640A (en) * | 1959-03-30 | 1962-10-30 | Monsanto Chemicals | 3, 4-dichlorophenyl dialkylaminoalkyl ureas and thioureas |
CH472835A (de) * | 1964-12-17 | 1969-05-31 | Ciba Geigy | Schädlingsbekämpfungsmittel |
GB1143802A (ko) * | 1965-03-25 | |||
GB1310224A (en) * | 1969-07-22 | 1973-03-14 | Lilly Industries Ltd | Oxazole thioureas |
CH543535A (de) * | 1970-07-24 | 1973-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Thiazolderivaten |
NL7108189A (ko) * | 1970-07-24 | 1972-01-26 | ||
DE2132431A1 (de) * | 1971-06-30 | 1973-01-11 | Riedel De Haen Ag | 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate |
DE2136233A1 (de) * | 1971-07-20 | 1973-02-01 | Riedel De Haen Ag | Tetrahydrobenzthiazolderivate enthaltende pharmazeutische praeparate |
SU517587A1 (ru) * | 1971-08-23 | 1976-06-15 | Медицинска Академие (Инопредприятие) | Способ получени производных 2оксфенилмочевины |
US4048333A (en) * | 1971-08-23 | 1977-09-13 | Medizinska Akademia | Method for treating a picorna virus infection |
GB1354830A (en) * | 1972-08-31 | 1974-06-05 | Dainippon Pharmaceutical Co | 1,3-disubstituted thiourea compounds their preparation and use |
US3950537A (en) | 1973-06-29 | 1976-04-13 | Rohm And Haas Company | Gastrointestinally active thioureas |
HU168393B (ko) * | 1973-11-09 | 1976-04-28 | ||
US3891769A (en) | 1974-02-01 | 1975-06-24 | Dow Chemical Co | Psychotherapeutic methods employing thioureas |
US3950538A (en) * | 1974-03-18 | 1976-04-13 | The Dow Chemical Company | Anti-inflammatory methods utilizing certain thioureas |
BE819436A (fr) * | 1974-08-30 | 1975-02-28 | Composition pharmaceutique renfermant des pyridylthiourees. | |
GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
DD123466A1 (ko) * | 1975-12-01 | 1976-12-20 | ||
US4066695A (en) * | 1976-04-15 | 1978-01-03 | Hoffmann-La Roche Inc. | Thiourea derivatives |
DK543178A (da) * | 1977-12-01 | 1979-06-02 | Wellcome Found | Thiodydantoinderivater |
JPS604830B2 (ja) * | 1979-04-24 | 1985-02-06 | 株式会社 大塚製薬工場 | フエニル酢酸誘導体 |
PL137012B1 (en) * | 1982-05-27 | 1986-04-30 | Politechnika Gdanska | Process for preparing 3,5-substituted derivatives of 2-thiohydantoin |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
PT82199B (pt) * | 1985-03-16 | 1990-11-07 | Wellcome Found | Processo para a preparacao de nucleosidos antivirais e de composicoes farmaceuticas que os contem |
DE3607381A1 (de) * | 1986-03-06 | 1987-09-10 | Pascal Zimmer | Verwendung von diphenylhydantoin und seinen derivaten zur behandlung von immunerkrankungen |
US4880836A (en) * | 1988-03-11 | 1989-11-14 | Danek Elbaum | Antiviral amphiphilics |
DE3815046A1 (de) * | 1988-05-04 | 1989-11-16 | Basf Ag | 3-chlor-2-methylphenethylaminoderivate |
IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them |
GB8908063D0 (en) * | 1989-04-11 | 1989-05-24 | Beecham Group Plc | Novel compounds |
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1992
- 1992-07-17 IL IL10254892A patent/IL102548A/en not_active IP Right Cessation
- 1992-07-21 AU AU20451/92A patent/AU657978B2/en not_active Ceased
- 1992-07-22 CZ CS922288A patent/CZ282900B6/cs unknown
- 1992-07-24 NO NO92922949A patent/NO922949L/no unknown
- 1992-07-28 ZA ZA925663A patent/ZA925663B/xx unknown
- 1992-07-29 HU HU9202477A patent/HU9202477D0/hu unknown
- 1992-07-29 ES ES09201601A patent/ES2051641B1/es not_active Expired - Fee Related
- 1992-07-30 CN CN92110630A patent/CN1069882A/zh active Pending
- 1992-07-30 FI FI923443A patent/FI923443A/fi unknown
- 1992-07-30 RU SU5052783A patent/RU2106341C1/ru active
- 1992-07-30 MX MX9204454A patent/MX9204454A/es unknown
- 1992-07-30 AP APAP/P/1992/000412A patent/AP384A/en active
- 1992-07-30 AP APAP/P/1995/000723A patent/AP388A/en active
- 1992-07-30 YU YU74292A patent/YU74292A/sh unknown
- 1992-07-31 CA CA002075173A patent/CA2075173C/en not_active Expired - Fee Related
- 1992-07-31 JP JP22521892A patent/JP3383328B2/ja not_active Expired - Fee Related
- 1992-07-31 KR KR1019920013801A patent/KR100252453B1/ko not_active IP Right Cessation
- 1992-08-03 AT AT92307092T patent/ATE232095T1/de not_active IP Right Cessation
- 1992-08-03 DE DE69232919T patent/DE69232919T2/de not_active Expired - Fee Related
- 1992-08-03 AU AU24074/92A patent/AU2407492A/en not_active Abandoned
- 1992-08-03 WO PCT/SE1992/000533 patent/WO1993003022A1/en active Application Filing
- 1992-08-03 EP EP92307092A patent/EP0540143B1/en not_active Expired - Lifetime
- 1992-10-20 TW TW081108324A patent/TW252110B/zh active
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1994
- 1994-01-28 OA OA60464A patent/OA09914A/en unknown
- 1994-02-28 BG BG98623A patent/BG98623A/bg unknown
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1995
- 1995-06-22 HU HU95P/P00395P patent/HU211164A9/hu unknown
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