SU517587A1 - Способ получени производных 2оксфенилмочевины - Google Patents
Способ получени производных 2оксфенилмочевиныInfo
- Publication number
- SU517587A1 SU517587A1 SU1823300A SU1823300A SU517587A1 SU 517587 A1 SU517587 A1 SU 517587A1 SU 1823300 A SU1823300 A SU 1823300A SU 1823300 A SU1823300 A SU 1823300A SU 517587 A1 SU517587 A1 SU 517587A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- preparing
- derivatives
- oxphenylurea
- product
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Description
растворе и температура плавлени очищенного .продукта составл ет 137-138° С.
Найдено, %: С 58,55; Н 4,66; N 9,43.
CisHisCINaSO.
Вычислено, %: С 58,82; Н 4,90; N 9,15.
Аналогично полученные вещества прюведены в та-бл. 1.
Пример 2. N-Бeнзил-N-(2-o.кcифeнил)N-п .ропилмоч евина.
2,0 г N-бензилбензаксазолона и 10,0 м.л 50%-HOiro водного раствора пролиламина кип т т совместно в течение 7 ч. После охлаждени реакционную смесь нейтрализуют и образовающийс осадок отфильтровывают. После растворени его в 10%:-ном растворе гидрата окиси натри продукт осаждают разбавленной сол ной кислотой, причем очищенный та.ким способом продукт имеет вес 1,85 г (72% от теоретического). Затем продукт перекристаллизовывают из спиртового раствора . Температура его плавлени составл ет 135-136° С.
Найдено, %: С 71,82; N 9,71; Н 7,15.
Ci7H2oN202.
Вычислено, %: С 71,83; N 9,85; Н 7,04.
Таблица I
Таблица 2
Ф О р м ула изобретени
Способ получени производных 2-оксифенил .мочевины общей формулы I
ОН
N(Ri)C(H3)NHEj GI - С4-ал.кил или бензил; - С - С4-ал«ил, бензил или циклогекКз - кислород или сера; Х--водород, хлор или сульфонамидна 15 группа; Y - водород или бром.
Продолжение табл. 2
отличающийс тем, что соединение общей формулы II
(П), где RI, Кз, X и Y имеют указанные выше значени , подвергают взаимодействию с избытком амина общей формулы III где RS имеет указанные выще значени , при 60-100° С.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG1722371 | 1971-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SU517587A1 true SU517587A1 (ru) | 1976-06-15 |
Family
ID=3897721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU1823300A SU517587A1 (ru) | 1971-08-23 | 1972-08-22 | Способ получени производных 2оксфенилмочевины |
Country Status (7)
Country | Link |
---|---|
US (1) | US3846491A (ru) |
JP (1) | JPS5734259B2 (ru) |
CH (1) | CH574401A5 (ru) |
DE (1) | DE2241471C3 (ru) |
FR (1) | FR2150833B1 (ru) |
GB (1) | GB1350710A (ru) |
SU (1) | SU517587A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2303761A1 (de) * | 1973-01-26 | 1974-08-01 | Henkel & Cie Gmbh | Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen |
JPS62137067U (ru) * | 1986-02-24 | 1987-08-28 | ||
IL102548A (en) * | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
JPH06182010A (ja) * | 1992-06-19 | 1994-07-05 | Mizuno Corp | Frp製バット |
CA2197364A1 (en) * | 1996-02-15 | 1997-08-16 | Toshikazu Suzuki | Phenol compound and process for preparing the same |
US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
WO2010021693A2 (en) * | 2008-08-18 | 2010-02-25 | Yale University | Mif modulators |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2795610A (en) * | 1955-03-31 | 1957-06-11 | Du Pont | Hydroxy-phenyl alkyl ureas |
-
1972
- 1972-08-22 SU SU1823300A patent/SU517587A1/ru active
- 1972-08-23 GB GB3933672A patent/GB1350710A/en not_active Expired
- 1972-08-23 US US00282917A patent/US3846491A/en not_active Expired - Lifetime
- 1972-08-23 CH CH1248672A patent/CH574401A5/xx not_active IP Right Cessation
- 1972-08-23 JP JP8442472A patent/JPS5734259B2/ja not_active Expired
- 1972-08-23 DE DE2241471A patent/DE2241471C3/de not_active Expired
- 1972-08-23 FR FR7230065A patent/FR2150833B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2150833B1 (ru) | 1975-10-17 |
US3846491A (en) | 1974-11-05 |
JPS4832843A (ru) | 1973-05-02 |
DE2241471C3 (de) | 1981-10-01 |
GB1350710A (en) | 1974-04-24 |
CH574401A5 (ru) | 1976-04-15 |
FR2150833A1 (ru) | 1973-04-13 |
JPS5734259B2 (ru) | 1982-07-22 |
DE2241471B2 (de) | 1980-11-06 |
DE2241471A1 (de) | 1973-03-22 |
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