ZA921328B - Hydrazone derivatives,their preparation and use - Google Patents

Hydrazone derivatives,their preparation and use

Info

Publication number
ZA921328B
ZA921328B ZA921328A ZA921328A ZA921328B ZA 921328 B ZA921328 B ZA 921328B ZA 921328 A ZA921328 A ZA 921328A ZA 921328 A ZA921328 A ZA 921328A ZA 921328 B ZA921328 B ZA 921328B
Authority
ZA
South Africa
Prior art keywords
alkyl
hydrogen
independently
benzyl
so2nr
Prior art date
Application number
ZA921328A
Other languages
English (en)
Inventor
Bjarne Hugo Dahl
Hugo Dahl Bjarne
Frank Watjen
Watjen Frank
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of ZA921328B publication Critical patent/ZA921328B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Holo Graphy (AREA)
  • Cephalosporin Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Hydrogenated Pyridines (AREA)
ZA921328A 1991-03-15 1992-02-24 Hydrazone derivatives,their preparation and use ZA921328B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/670,061 US5164404A (en) 1991-03-15 1991-03-15 Hydrazone derivatives and their use

Publications (1)

Publication Number Publication Date
ZA921328B true ZA921328B (en) 1992-11-25

Family

ID=24688827

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA921328A ZA921328B (en) 1991-03-15 1992-02-24 Hydrazone derivatives,their preparation and use

Country Status (16)

Country Link
US (1) US5164404A (xx)
EP (1) EP0503349B1 (xx)
JP (1) JP3407896B2 (xx)
KR (1) KR100192641B1 (xx)
AT (1) ATE116639T1 (xx)
AU (1) AU643877B2 (xx)
CA (1) CA2062853A1 (xx)
DE (1) DE69201068T2 (xx)
DK (1) DK0503349T3 (xx)
ES (1) ES2069330T3 (xx)
FI (1) FI103276B1 (xx)
GR (1) GR3015671T3 (xx)
IE (1) IE66111B1 (xx)
NO (1) NO180191C (xx)
NZ (1) NZ241752A (xx)
ZA (1) ZA921328B (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9109007D0 (en) * 1991-04-26 1991-06-12 Merck Sharp & Dohme Therapeutic method
AU655643B2 (en) * 1991-07-09 1995-01-05 Neurosearch A/S Novel isatineoxime derivatives, their preparation and use
DK69693D0 (da) * 1993-06-14 1993-06-14 Neurosearch As Farven lilla
US5565580A (en) * 1994-01-27 1996-10-15 Neurosearch A/S Glutamate Antagonists
US5773434A (en) * 1995-08-30 1998-06-30 Gary A. Rogers Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
KR19980050063A (ko) * 1996-12-20 1998-09-15 이덕림 신규한 하이드라존 유도체
AR016384A1 (es) * 1997-07-30 2001-07-04 Smithkline Beecham Corp Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
AR016551A1 (es) * 1997-07-30 2001-07-25 Smithkline Beecham Corp Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
ATE249828T1 (de) 1998-03-06 2003-10-15 Astrazeneca Ab Verwendung von isatin- und oxindolderivaten zur herstellung von arzeneimittel für die behandlung von mykobakteriellen erkrankungen
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
EP1242081A4 (en) * 1999-09-30 2004-07-21 Smithkline Beecham Corp CASPASES AND APOPTOSIS
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
US6589504B1 (en) * 2000-09-22 2003-07-08 Pharmacia & Upjohn Company Compounds and methods for diagnosing and treating amyloid-related conditions
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
BRPI0511057A (pt) * 2004-05-12 2007-11-27 Bayer Cropscience Gmbh regulação de crescimento da planta
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
EP1805155B1 (en) * 2004-10-25 2010-11-03 Ligand Pharmaceuticals, Inc. Thrombopoietin activity modulating compounds and methods
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
CN115304536B (zh) * 2022-07-26 2023-09-22 合肥工业大学 一种吲哚啉-2-酮化合物衍生物的制备及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2314242A1 (de) * 1973-03-22 1974-09-26 Bayer Ag Neue 3-substituierte 2-oxo-4-hydroxy1,2,3,4-tetrahydrochinazolin-4-carbonsaeurehydrazide
US4780477A (en) * 1985-06-08 1988-10-25 Kissei Pharmaceutical Co., Ltd. Isatin compositions having anti-ulcer activities
US4988710A (en) * 1989-08-25 1991-01-29 Washington University Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
IE66111B1 (en) 1995-12-13
NO921000L (no) 1992-09-16
KR100192641B1 (ko) 1999-06-15
EP0503349B1 (en) 1995-01-04
EP0503349A1 (en) 1992-09-16
NZ241752A (en) 1994-05-26
DE69201068T2 (de) 1995-05-11
KR920017650A (ko) 1992-10-21
JPH0578350A (ja) 1993-03-30
NO180191B (no) 1996-11-25
ES2069330T3 (es) 1995-05-01
AU643877B2 (en) 1993-11-25
US5164404A (en) 1992-11-17
DE69201068D1 (de) 1995-02-16
NO180191C (no) 1997-03-05
IE920643A1 (en) 1992-09-23
FI103276B (fi) 1999-05-31
JP3407896B2 (ja) 2003-05-19
FI921049A0 (fi) 1992-03-11
FI921049A (fi) 1992-09-16
DK0503349T3 (da) 1995-05-08
NO921000D0 (no) 1992-03-13
ATE116639T1 (de) 1995-01-15
GR3015671T3 (en) 1995-07-31
AU1122592A (en) 1992-09-17
FI103276B1 (fi) 1999-05-31
CA2062853A1 (en) 1992-09-16

Similar Documents

Publication Publication Date Title
ZA921328B (en) Hydrazone derivatives,their preparation and use
DK46789D0 (da) 3-indolpyrodruesyrederivater og farmaceutisk anvendelse deraf
HUP0003644A2 (hu) 2,3-Diaril-pirazolo[1,5-b]piridazin-származékok, ezeket tartalmazó gyógyászati készítmények ciklooxigenáz 2(COX-2) gátlására, valamint eljárás a vegyületek előállítására
IL83691A (en) Acylated quinolinamines, their preparation and pharmaceutical compositions containing them
HUP0002830A2 (hu) Indol- és 2,3-dihidroindol-származékok, előállításuk és gyógyászati alkalmazásuk
IL81887A0 (en) Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
DK0432648T3 (da) Isatinderivater, deres fremstilling og anvendelse
DK0583485T3 (da) Ethanolaminderivater med sympathomimetiske og anti-pollakisuria-virkninger
ES2157565T3 (es) N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.
ATE229953T1 (de) Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
IL104657A0 (en) Benzazepine derivatives,their preparation and pharmaceutical compositions containing them
DK0633262T3 (da) Hidtil ukendte isatinoximderivater samt fremstilling og anvendelse heraf
ZA892258B (en) Use of isoxazolinones as cerebro-active drugs
DE69827706D1 (de) 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
IT8509443A0 (it) Interforometro per spettroscopia dell'ultravioletto e visibile del tipo trasformata di fourier, senza parti mobili