EP1242081A4 - Caspases and apoptosis - Google Patents

Caspases and apoptosis

Info

Publication number
EP1242081A4
EP1242081A4 EP00965555A EP00965555A EP1242081A4 EP 1242081 A4 EP1242081 A4 EP 1242081A4 EP 00965555 A EP00965555 A EP 00965555A EP 00965555 A EP00965555 A EP 00965555A EP 1242081 A4 EP1242081 A4 EP 1242081A4
Authority
EP
European Patent Office
Prior art keywords
caspases
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00965555A
Other languages
German (de)
French (fr)
Other versions
EP1242081A1 (en
Inventor
Dennis Lee
Scott A Long
John D Elliott
John G Gleason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1242081A1 publication Critical patent/EP1242081A1/en
Publication of EP1242081A4 publication Critical patent/EP1242081A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
EP00965555A 1999-09-30 2000-09-29 Caspases and apoptosis Withdrawn EP1242081A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15687799P 1999-09-30 1999-09-30
US156877P 1999-09-30
PCT/US2000/027030 WO2001022966A1 (en) 1999-09-30 2000-09-29 Caspases and apoptosis

Publications (2)

Publication Number Publication Date
EP1242081A1 EP1242081A1 (en) 2002-09-25
EP1242081A4 true EP1242081A4 (en) 2004-07-21

Family

ID=22561469

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00965555A Withdrawn EP1242081A4 (en) 1999-09-30 2000-09-29 Caspases and apoptosis

Country Status (4)

Country Link
EP (1) EP1242081A4 (en)
JP (1) JP2003510278A (en)
AU (1) AU7625500A (en)
WO (1) WO2001022966A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094311A1 (en) * 2000-06-08 2001-12-13 Mitsubishi Pharma Corporation Cytoprotectors
GB0225938D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
NZ541064A (en) 2003-03-07 2007-09-28 Kowa Co Benzofuran derivative
US8440841B2 (en) 2005-01-17 2013-05-14 Universitätsklinikum Münster 5-pyrrolidinylsulfonyl isatin derivatives
US8961930B2 (en) 2008-09-05 2015-02-24 Imperial Innovations Limited Isatin derivatives for use as in vivo imaging agents
EP2563761A1 (en) 2010-04-29 2013-03-06 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
CN103183631B (en) * 2011-12-28 2016-08-24 天津市国际生物医药联合研究院 Isatin-5-sulfonic acid amide derivatives and the application in the medicine of preparation treatment severe acute respiratory syndrome thereof
CN110818619B (en) * 2019-12-13 2021-03-02 山东铂源药业有限公司 Synthetic method of N- (3-chloro-4- (2-pyridylmethoxy) phenyl) -2-cyanoacetamide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006367A1 (en) * 1997-07-30 1999-02-11 Smithkline Beecham Corporation Caspases and apoptosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164404A (en) * 1991-03-15 1992-11-17 Neurosearch A/S Hydrazone derivatives and their use
US5223527A (en) * 1991-07-09 1993-06-29 Neurosearch A/S Isatineoxime derivatives and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006367A1 (en) * 1997-07-30 1999-02-11 Smithkline Beecham Corporation Caspases and apoptosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AYAKOVLEV A G ET AL: "ACTIVATION OF CPP32-LIKE CASPASES CONTRIBUTES TO NEURONAL APOPTOSISAND NEUROLOGICAL DYSFUNCTION AFTER TRAUMATIC BRAIN INJURY", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 17, no. 19, 1 October 1997 (1997-10-01), pages 7415 - 7424, XP002916412, ISSN: 0270-6474 *
See also references of WO0122966A1 *

Also Published As

Publication number Publication date
WO2001022966A1 (en) 2001-04-05
AU7625500A (en) 2001-04-30
EP1242081A1 (en) 2002-09-25
JP2003510278A (en) 2003-03-18

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020426

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20040604

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 31/404 B

Ipc: 7A 61K 31/445 A

Ipc: 7A 61K 31/40 B

Ipc: 7A 61K 31/44 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040820