ZA915446B - Growth hormone crystals and a process for production of these gh-crystals - Google Patents

Growth hormone crystals and a process for production of these gh-crystals

Info

Publication number
ZA915446B
ZA915446B ZA915446A ZA915446A ZA915446B ZA 915446 B ZA915446 B ZA 915446B ZA 915446 A ZA915446 A ZA 915446A ZA 915446 A ZA915446 A ZA 915446A ZA 915446 B ZA915446 B ZA 915446B
Authority
ZA
South Africa
Prior art keywords
crystals
production
growth hormone
hgh
divalent cation
Prior art date
Application number
ZA915446A
Other languages
English (en)
Inventor
Flemming Junker
Junker Flemming
Claus Friis Theisen
Friis Theisen Claus
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA915446B publication Critical patent/ZA915446B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA915446A 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals ZA915446B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK168790A DK168790D0 (OSRAM) 1990-07-13 1990-07-13

Publications (1)

Publication Number Publication Date
ZA915446B true ZA915446B (en) 1992-03-25

Family

ID=8107212

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA915446A ZA915446B (en) 1990-07-13 1991-07-12 Growth hormone crystals and a process for production of these gh-crystals

Country Status (17)

Country Link
US (1) US6117984A (OSRAM)
EP (1) EP0540582B1 (OSRAM)
JP (1) JP2524446B2 (OSRAM)
AT (1) ATE110745T1 (OSRAM)
AU (1) AU666465B2 (OSRAM)
BG (1) BG61267B1 (OSRAM)
CA (1) CA2086087C (OSRAM)
DE (1) DE69103755T2 (OSRAM)
DK (2) DK168790D0 (OSRAM)
ES (1) ES2060399T3 (OSRAM)
HU (2) HUT64086A (OSRAM)
IE (1) IE67054B1 (OSRAM)
NZ (1) NZ238904A (OSRAM)
PT (1) PT98297B (OSRAM)
RU (1) RU2108341C1 (OSRAM)
WO (1) WO1992000998A1 (OSRAM)
ZA (1) ZA915446B (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK168790D0 (OSRAM) * 1990-07-13 1990-07-13 Novo Nordisk As
US6894023B1 (en) * 1990-07-13 2005-05-17 Novo Nordisk A/S Growth hormone crystals and a process for production of these GH-crystals
HUT69402A (en) * 1991-12-20 1995-09-28 Novo Nordisk As Process for producing stabilized pharmaceutical formulations comprising growth hormone and histidine
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
KR20000057693A (ko) 1996-12-20 2000-09-25 다케다 야쿠힌 고교 가부시키가이샤 지효성 제제의 제조 방법
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物
US7101575B2 (en) 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US6451347B1 (en) 1999-03-01 2002-09-17 Alkermes Controlled Therapeutics, Inc. Method for purifying human growth hormone
ATE226267T1 (de) * 1999-06-10 2002-11-15 Max Planck Gesellschaft Einkapselung von kristallen mit mehrschichtigem überzug
US6566329B1 (en) 1999-06-28 2003-05-20 Novo Nordisk A/S Freeze-dried preparation of human growth hormone
TWI283182B (en) 2000-08-07 2007-07-01 Nektar Therapeutics Inhalable spray dried 4-helix bundle protein powders having minimized aggregation
ATE409465T1 (de) 2000-10-06 2008-10-15 Pacira Pharmaceuticals Inc Parenteral verabreichbare mikropartikel- zubereitung mit kontrollierter freisetzung
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US7105181B2 (en) 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
SE0201599D0 (sv) 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
SE0202719D0 (sv) * 2002-09-13 2002-09-13 Pharmacia Ab Process for mfg crystals of growth hormone
SG176314A1 (en) 2002-12-31 2011-12-29 Altus Pharmaceuticals Inc Human growth hormone crystals and methods for preparing them
BR0317896A (pt) * 2002-12-31 2005-12-06 Altus Pharmaceuticals Inc Complexos de cristais de proteìna e polìmeros iÈnicos
CN1744914A (zh) * 2002-12-31 2006-03-08 阿尔特斯制药公司 人生长激素晶体和制备它们的方法
WO2005014034A1 (en) * 2003-07-14 2005-02-17 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
US20090023629A1 (en) * 2005-12-23 2009-01-22 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
WO2008076819A2 (en) * 2006-12-18 2008-06-26 Altus Pharmaceuticals Inc. Human growth hormone formulations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA653324A (en) * 1962-12-04 G. Brink Norman Growth hormone and methods of preparing the same
US2143590A (en) * 1936-09-26 1939-01-10 Univ Alberta Insulin preparation and process of producing crystals of insulin
US2174862A (en) * 1938-12-30 1939-10-03 Frederick Stearns & Company Process of producing crystalline insulin
US2595278A (en) * 1950-04-28 1952-05-06 Armour & Co Preparation of insulin from pancreas glands
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
US2897117A (en) * 1955-02-10 1959-07-28 Univ Alberta Insulin process
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
KR890002631B1 (ko) * 1984-10-04 1989-07-21 몬산토 캄파니 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
EP0343696B1 (en) * 1984-10-04 1996-01-03 Monsanto Company Zinc-associated somatotropins
IL79681A (en) * 1985-08-12 1991-06-10 Int Minerals & Chem Corp Transition metal complexes of growth hormones and their prolonged release compositions
JPS63216898A (ja) * 1987-01-30 1988-09-09 インターナシヨナル・ミネラルズ・アンド・ケミカル・コーポレイシヨン 希薄水溶液からソマトトロビンを回収する方法
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
ATE198353T1 (de) * 1988-08-24 2001-01-15 American Cyanamid Co Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
US5780599A (en) * 1990-07-13 1998-07-14 Novo Nordisk A/S Growth hormone crystals and a process for production of growth hormone crystals
DK168790D0 (OSRAM) * 1990-07-13 1990-07-13 Novo Nordisk As

Also Published As

Publication number Publication date
EP0540582A1 (en) 1993-05-12
RU2108341C1 (ru) 1998-04-10
BG97281A (bg) 1994-03-24
JP2524446B2 (ja) 1996-08-14
DK0540582T3 (da) 1995-01-30
HUT64086A (en) 1993-11-29
DK168790D0 (OSRAM) 1990-07-13
IE67054B1 (en) 1996-02-21
HU9300067D0 (en) 1993-04-28
DE69103755T2 (de) 1995-02-23
ATE110745T1 (de) 1994-09-15
HU210323B (en) 1995-03-28
BG61267B1 (en) 1997-04-30
JPH05507497A (ja) 1993-10-28
AU666465B2 (en) 1996-02-15
NZ238904A (en) 1993-04-28
AU8284691A (en) 1992-02-04
CA2086087C (en) 1999-09-14
DE69103755D1 (de) 1994-10-06
CA2086087A1 (en) 1992-01-14
ES2060399T3 (es) 1994-11-16
PT98297A (pt) 1992-05-29
EP0540582B1 (en) 1994-08-31
IE912444A1 (en) 1992-01-15
PT98297B (pt) 1999-01-29
WO1992000998A1 (en) 1992-01-23
US6117984A (en) 2000-09-12

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