ZA91392B - Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase - Google Patents
Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidaseInfo
- Publication number
- ZA91392B ZA91392B ZA91392A ZA91392A ZA91392B ZA 91392 B ZA91392 B ZA 91392B ZA 91392 A ZA91392 A ZA 91392A ZA 91392 A ZA91392 A ZA 91392A ZA 91392 B ZA91392 B ZA 91392B
- Authority
- ZA
- South Africa
- Prior art keywords
- squalene
- tetra
- inhibitors
- fluoro analogs
- epoxidase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C21/00—Acyclic unsaturated compounds containing halogen atoms
- C07C21/02—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds
- C07C21/215—Halogenated polyenes with more than two carbon-to-carbon double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/502,203 US5011859A (en) | 1990-03-30 | 1990-03-30 | Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA91392B true ZA91392B (en) | 1991-10-30 |
Family
ID=23996803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA91392A ZA91392B (en) | 1990-03-30 | 1991-01-18 | Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5011859A (hu) |
| EP (1) | EP0448934B1 (hu) |
| JP (1) | JP2911239B2 (hu) |
| KR (1) | KR0162659B1 (hu) |
| CN (1) | CN1055172A (hu) |
| AT (1) | ATE118756T1 (hu) |
| AU (1) | AU629726B2 (hu) |
| CA (1) | CA2034612C (hu) |
| DE (1) | DE69107488T2 (hu) |
| ES (1) | ES2071131T3 (hu) |
| FI (1) | FI910425A (hu) |
| HU (1) | HU208103B (hu) |
| IE (1) | IE910181A1 (hu) |
| IL (1) | IL97356A0 (hu) |
| NO (1) | NO910263L (hu) |
| NZ (1) | NZ236800A (hu) |
| PH (1) | PH27365A (hu) |
| PT (1) | PT96654A (hu) |
| ZA (1) | ZA91392B (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7238394A (en) * | 1993-07-29 | 1995-02-28 | Chugai Seiyaku Kabushiki Kaisha | Tricarboxylic acid derivative having squalene synthetase inhibitor activity |
| DE19754795A1 (de) * | 1997-12-10 | 1999-06-17 | Boehringer Ingelheim Pharma | Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| US6103733A (en) * | 1998-09-09 | 2000-08-15 | Bachmann; Kenneth A. | Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| US20100331298A1 (en) * | 2007-12-10 | 2010-12-30 | Cytopathfinder, Inc. | Carboxamide Compounds and Their Use |
| EP2280766A1 (en) | 2007-12-11 | 2011-02-09 | CytoPathfinder, Inc. | Carboxamide compounds and their use as chemokine receptor agonists |
| US20130072519A1 (en) | 2010-05-21 | 2013-03-21 | Edward Lee Conn | 2-phenyl benzoylamides |
| EP2680874A2 (en) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-like peptides and uses thereof |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| JP7128969B2 (ja) | 2019-01-18 | 2022-08-31 | アストラゼネカ・アクチエボラーグ | Ｐｃｓｋ９阻害剤及びその使用方法 |
| CN112678833B (zh) * | 2020-11-17 | 2023-08-04 | 广西中烟工业有限责任公司 | 纳米二氧化硅改性角鲨烯有机硅颗粒及其制备和使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876672A (en) * | 1972-02-21 | 1975-04-08 | Du Pont | Hydroformylation of olefins |
| DE2913677C2 (de) * | 1979-04-05 | 1983-03-03 | Union Rheinische Braunkohlen Kraftstoff AG, 5000 Köln | Verfahren zur Herstellung von Acetaldehyddimethylacetal |
| US4455441A (en) * | 1982-09-24 | 1984-06-19 | Research Foundation Of State University Of New York | Attractant termiticidal compounds, compositions and methods of use therefor |
| DE3618115A1 (de) * | 1986-05-30 | 1987-12-03 | Bayer Ag | Halogenolefine |
| US4876295A (en) * | 1987-03-11 | 1989-10-24 | The Dow Chemical Company | Flexible thermoplastic epoxy resin and coatings prepared therefrom |
-
1990
- 1990-03-30 US US07/502,203 patent/US5011859A/en not_active Expired - Fee Related
-
1991
- 1991-01-17 NZ NZ236800A patent/NZ236800A/xx unknown
- 1991-01-18 IE IE018191A patent/IE910181A1/en unknown
- 1991-01-18 HU HU91174A patent/HU208103B/hu not_active IP Right Cessation
- 1991-01-18 ZA ZA91392A patent/ZA91392B/xx unknown
- 1991-01-18 AU AU69468/91A patent/AU629726B2/en not_active Ceased
- 1991-01-21 CA CA002034612A patent/CA2034612C/en not_active Expired - Fee Related
- 1991-01-23 NO NO91910263A patent/NO910263L/no unknown
- 1991-01-28 AT AT91101057T patent/ATE118756T1/de not_active IP Right Cessation
- 1991-01-28 DE DE69107488T patent/DE69107488T2/de not_active Expired - Fee Related
- 1991-01-28 EP EP91101057A patent/EP0448934B1/en not_active Expired - Lifetime
- 1991-01-28 ES ES91101057T patent/ES2071131T3/es not_active Expired - Lifetime
- 1991-01-29 FI FI910425A patent/FI910425A/fi unknown
- 1991-01-30 KR KR1019910001556A patent/KR0162659B1/ko not_active IP Right Cessation
- 1991-02-01 PT PT96654A patent/PT96654A/pt unknown
- 1991-02-08 JP JP3037724A patent/JP2911239B2/ja not_active Expired - Fee Related
- 1991-02-25 IL IL97356A patent/IL97356A0/xx unknown
- 1991-03-25 CN CN91101860A patent/CN1055172A/zh active Pending
-
1993
- 1993-06-21 PH PH27365A patent/PH27365A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2071131T3 (es) | 1995-06-16 |
| CA2034612C (en) | 2001-05-15 |
| PH27365A (en) | 1993-06-21 |
| CN1055172A (zh) | 1991-10-09 |
| EP0448934B1 (en) | 1995-02-22 |
| EP0448934A2 (en) | 1991-10-02 |
| FI910425A (fi) | 1991-10-01 |
| NZ236800A (en) | 1993-05-26 |
| US5011859A (en) | 1991-04-30 |
| IL97356A0 (en) | 1992-05-25 |
| AU6946891A (en) | 1991-10-03 |
| HUT56533A (en) | 1991-09-30 |
| NO910263L (no) | 1991-10-01 |
| AU629726B2 (en) | 1992-10-08 |
| HU208103B (en) | 1993-08-30 |
| EP0448934A3 (en) | 1991-11-27 |
| DE69107488D1 (de) | 1995-03-30 |
| JP2911239B2 (ja) | 1999-06-23 |
| JPH04221327A (ja) | 1992-08-11 |
| ATE118756T1 (de) | 1995-03-15 |
| FI910425A0 (fi) | 1991-01-29 |
| KR910016660A (ko) | 1991-11-05 |
| KR0162659B1 (ko) | 1999-01-15 |
| HU910174D0 (en) | 1991-08-28 |
| CA2034612A1 (en) | 1991-10-01 |
| PT96654A (pt) | 1991-10-31 |
| NO910263D0 (no) | 1991-01-23 |
| DE69107488T2 (de) | 1995-06-14 |
| IE910181A1 (en) | 1991-10-09 |
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