ZA912935B - Antiinflammatory hydroxamic acids and n-hydroxyureas - Google Patents

Antiinflammatory hydroxamic acids and n-hydroxyureas

Info

Publication number
ZA912935B
ZA912935B ZA912935A ZA912935A ZA912935B ZA 912935 B ZA912935 B ZA 912935B ZA 912935 A ZA912935 A ZA 912935A ZA 912935 A ZA912935 A ZA 912935A ZA 912935 B ZA912935 B ZA 912935B
Authority
ZA
South Africa
Prior art keywords
hydroxyureas
antiinflammatory
hydroxamic acids
sulfur
oxygen
Prior art date
Application number
ZA912935A
Other languages
English (en)
Inventor
Rodney William Stevens
William Stevens Rodney
Hiroaki Wakabayashi
Wakabayashi Hiroaki
Takafumi Ikeda
Ikeda Takafumi
Masami Nakane
Nakane Masami
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA912935B publication Critical patent/ZA912935B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G15/00—Apparatus for electrographic processes using a charge pattern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Quinoline Compounds (AREA)
  • Projection Apparatus (AREA)
ZA912935A 1990-04-20 1991-04-19 Antiinflammatory hydroxamic acids and n-hydroxyureas ZA912935B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10504890 1990-04-20

Publications (1)

Publication Number Publication Date
ZA912935B true ZA912935B (en) 1992-11-25

Family

ID=14397114

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA912935A ZA912935B (en) 1990-04-20 1991-04-19 Antiinflammatory hydroxamic acids and n-hydroxyureas

Country Status (29)

Country Link
US (1) US5256789A (zh)
EP (1) EP0525111B1 (zh)
JP (1) JPH075560B2 (zh)
KR (1) KR900016822A (zh)
CN (1) CN1033325C (zh)
AT (1) ATE123764T1 (zh)
AU (1) AU646865B2 (zh)
BR (1) BR9106367A (zh)
CA (1) CA2078216A1 (zh)
CS (1) CS110491A3 (zh)
DE (1) DE69110460T2 (zh)
DK (1) DK0525111T3 (zh)
EG (1) EG19608A (zh)
ES (1) ES2073755T3 (zh)
FI (1) FI924725A (zh)
GR (1) GR3017078T3 (zh)
HU (1) HUT61723A (zh)
IE (1) IE66530B1 (zh)
IL (1) IL97866A (zh)
MY (1) MY106510A (zh)
NO (1) NO180482C (zh)
NZ (1) NZ237884A (zh)
PL (1) PL165843B1 (zh)
PT (1) PT97422A (zh)
RU (1) RU2108324C1 (zh)
TW (1) TW206221B (zh)
WO (1) WO1991016298A1 (zh)
YU (1) YU48329B (zh)
ZA (1) ZA912935B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
WO1991014674A2 (en) * 1990-03-27 1991-10-03 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
US5260316A (en) * 1991-07-30 1993-11-09 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5334600A (en) * 1991-07-30 1994-08-02 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5350761A (en) * 1991-07-30 1994-09-27 Ciba-Geigy Corporation Indolyl substituted hydroxylamine derivatives
JP3226174B2 (ja) * 1992-04-07 2001-11-05 メレルダウファーマスーティカルズ インコーポレイテッド ３，４−ジヒドロ−２ｈ−１−ベンゾピラン類のヒドラジド誘導体類
JP2661841B2 (ja) * 1992-07-23 1997-10-08 ファイザー製薬株式会社 インドリン誘導体
PT850215E (pt) 1995-07-26 2001-03-30 Pfizer Derivados de acidos n-(aroil)glicina-hidroxamicos e compostos relacionados
WO2001087834A1 (fr) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
CN101437524B (zh) * 2004-09-14 2012-01-11 法莫赛特股份有限公司 2＇-氟-2＇-烷基-取代的或其它任选取代的呋喃核糖基嘧啶和嘌呤及其衍生物的制备
US20090036484A1 (en) * 2004-10-29 2009-02-05 Astrazeneca Ab Use of Unsaturated Quionoline or Naphtalene Derivatives as Medicaments
FR2881137B1 (fr) * 2005-01-27 2007-03-02 Servier Lab Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1909783B1 (en) * 2005-08-03 2011-10-12 The Regents of the University of California Illudin analogs useful as anticancer agents
US8512464B2 (en) 2009-12-02 2013-08-20 3M Innovative Properties Company Functionalized zirconia nanoparticles and high index films made therefrom
US20130096159A1 (en) * 2010-05-18 2013-04-18 The United States of America, as represented the Secretary Department of Health & Human Service Inhibitors of human 12-lipoxygenase
WO2012093100A1 (en) * 2011-01-05 2012-07-12 Syngenta Participations Ag Pyrazol-4-yl carboxamide derivatives as microbiocides
WO2015074064A2 (en) 2013-11-18 2015-05-21 Bair Kenneth W Tetrahydroquinoline compositions as bet bromodomain inhibitors
EP3071205B1 (en) 2013-11-18 2020-02-05 Forma Therapeutics, Inc. Benzopiperazine compositions as bet bromodomain inhibitors
AU2017257151A1 (en) * 2016-04-29 2018-11-15 Board Of Regents, The University Of Texas System Sigma receptor binders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO165341C (no) * 1985-03-16 1991-01-30 Wellcome Found Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksamsyrearylderivater.
US4728670A (en) * 1986-06-04 1988-03-01 E. R. Squibb & Sons, Inc. Biphenyl hydroxamic acids
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
US4897422A (en) * 1987-02-10 1990-01-30 Abbott Laboratories Lipoxygenase inhibiting compounds
ES2053609T3 (es) * 1987-04-24 1994-08-01 Abbott Lab Derivados de urea inhibidores de lipoxigenasa.
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
DK418289A (da) * 1989-08-24 1991-02-25 Micro Matic As Sikringssystem for anstikker

Also Published As

Publication number Publication date
IE911310A1 (en) 1991-10-23
TW206221B (zh) 1993-05-21
CN1033325C (zh) 1996-11-20
HU9203286D0 (en) 1992-12-28
JPH075560B2 (ja) 1995-01-25
PT97422A (pt) 1992-01-31
NO180482B (no) 1997-01-20
IE66530B1 (en) 1995-01-24
FI924725A0 (fi) 1992-10-19
EP0525111B1 (en) 1995-06-14
GR3017078T3 (en) 1995-11-30
WO1991016298A1 (en) 1991-10-31
ES2073755T3 (es) 1995-08-16
FI924725A (fi) 1992-10-19
RU2108324C1 (ru) 1998-04-10
DK0525111T3 (da) 1995-08-07
CN1060286A (zh) 1992-04-15
MY106510A (en) 1995-06-30
CA2078216A1 (en) 1991-10-21
US5256789A (en) 1993-10-26
NO924045L (no) 1992-10-19
NO180482C (no) 1997-04-30
YU71091A (sh) 1994-04-05
EG19608A (en) 1995-08-30
YU48329B (sh) 1998-05-15
NO924045D0 (no) 1992-10-19
EP0525111A1 (en) 1993-02-03
AU646865B2 (en) 1994-03-10
BR9106367A (pt) 1993-04-27
NZ237884A (en) 1993-08-26
CS110491A3 (en) 1992-02-19
KR900016822A (ko) 1990-11-14
HUT61723A (en) 1993-03-01
IL97866A (en) 1997-11-20
DE69110460D1 (de) 1995-07-20
IL97866A0 (en) 1992-06-21
JPH0665204A (ja) 1994-03-08
DE69110460T2 (de) 1995-10-05
AU7798691A (en) 1991-11-11
ATE123764T1 (de) 1995-06-15
PL165843B1 (pl) 1995-02-28

Similar Documents

Publication Publication Date Title
GR3017078T3 (en) Antiinflammatory hydroxamic acids and n-hydroxyureas.
FI932249A0 (fi) Dubbelverkande inhibitorer
GB2303850A (en) Metalloproteinase inhibitors
CA2255951A1 (en) Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
HK1003938A1 (en) Thiazole derivatives as active oxygen inhibitors
MY128063A (en) Aromatic heterocyclic compound as antiinflammatory agents
CA2123048A1 (en) Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments
HUT76548A (en) Aryl-sulfonamido-hydroxamic acids of matrix-metalloproteinase-inhibiting activity
ZA919317B (en) Novel hydroxamic acid and N-hydroxyurea derivatives and their use.
UA37181C2 (uk) ГІДРОХЛОРИД 7-<font face="Symbol">b</font>-[(Z)-2-(2-АМІНО-4-ТІАЗОЛІЛ)-3-ГІДРОКСИІМІНОАЦЕТА- МІДО]-3-(1,2,3-ТРИАЗОЛ-4-ІЛ)ТІОМЕТИЛТІО-3-ЦЕФЕМ-4-КАРБОНОВОЇ КИСЛОТИ АБО ЙОГО ГІДРАТИ, ЩО МАЮТЬ АНТИБАКТЕРІАЛЬНУ ДІЮ, ФАРМАЦЕВТИЧНА АНТИБАКТЕРІАЛЬНА КОМПОЗИЦІЯ, СПОСІБ ПРИГНІЧЕННЯ РОЗВИТКУ БАКТЕРІЙ, СПОСІБ ЛІКУВАННЯ БАКТЕРІАЛЬНИХ ІНФЕКЦІЙ
RU92016453A (ru) Гидроксамовые кислоты и n-гидроксимочевины, способы их получения, фармацевтическая композиция и способ ингибирования липоксигеназы
CZ20013522A3 (cs) Sloučeniny inhibující adhezi buněk vykazující protizánětlivé a imunosupresivní účinky
ATE227293T1 (de) 2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one
ZA911728B (en) Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
EP0310072A3 (en) Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
EP0293751A3 (en) Taurohyodeoxycholic acid for the therapy of calculosis of the biliary tract and of biliary dyspepsia
EP0313847A3 (en) Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents
EA200000204A1 (ru) Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
CA2139731A1 (en) 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
NZ322777A (en) Sulfur containing di-tert-butylphenol compounds useful as anti-inflammatory agents
DK0561882T3 (da) Hydroxamsyrederivater, som inhiberer lipoxygenase
DK0775692T3 (da) Guanidinomethylcyclohexancarboxylsyreesterderivater
SE9902596D0 (sv) Pharmaceutically active compounds
RU94019328A (ru) α- ГЕТЕРОАРИЛОКСИМЕТИЛКЕТОНЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИНГИБИРУЮЩАЯ ИНТЕРЛЕЙКИН-1 - β -ПРОТЕАЗУ
NO20012101L (no) Fremgangsmåte for fremstilling av <alfa>-arylalkansyrer