ZA912783B - 4-(3-(4-oxothiazoldinyl))butynylamines,a process for their preparation and their use as medicaments - Google Patents

4-(3-(4-oxothiazoldinyl))butynylamines,a process for their preparation and their use as medicaments

Info

Publication number
ZA912783B
ZA912783B ZA912783A ZA912783A ZA912783B ZA 912783 B ZA912783 B ZA 912783B ZA 912783 A ZA912783 A ZA 912783A ZA 912783 A ZA912783 A ZA 912783A ZA 912783 B ZA912783 B ZA 912783B
Authority
ZA
South Africa
Prior art keywords
oxothiazoldinyl
butynylamines
medicaments
preparation
Prior art date
Application number
ZA912783A
Other languages
English (en)
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA912783B publication Critical patent/ZA912783B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
ZA912783A 1990-04-16 1991-04-15 4-(3-(4-oxothiazoldinyl))butynylamines,a process for their preparation and their use as medicaments ZA912783B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/509,280 US5034392A (en) 1990-04-16 1990-04-16 4-(3-(4-oxothiazolidinyl)butynylamines

Publications (1)

Publication Number Publication Date
ZA912783B true ZA912783B (en) 1991-12-24

Family

ID=24025983

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA912783A ZA912783B (en) 1990-04-16 1991-04-15 4-(3-(4-oxothiazoldinyl))butynylamines,a process for their preparation and their use as medicaments

Country Status (26)

Country Link
US (1) US5034392A (no)
EP (1) EP0452850B1 (no)
JP (1) JPH07119223B2 (no)
KR (1) KR0163598B1 (no)
AR (1) AR248402A1 (no)
AT (1) ATE163010T1 (no)
AU (1) AU636972B2 (no)
BG (1) BG60066A3 (no)
CA (1) CA2040489C (no)
CZ (1) CZ284447B6 (no)
DE (1) DE69128845T2 (no)
DK (1) DK0452850T3 (no)
ES (1) ES2112844T3 (no)
FI (1) FI94755C (no)
GR (1) GR3026319T3 (no)
HU (1) HUT61017A (no)
IE (1) IE911257A1 (no)
IL (1) IL97852A (no)
MX (1) MX25359A (no)
NO (1) NO300134B1 (no)
NZ (1) NZ237811A (no)
PL (1) PL165488B1 (no)
PT (1) PT97371B (no)
RO (1) RO108683B1 (no)
RU (1) RU2001914C1 (no)
ZA (1) ZA912783B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273977A (en) * 1990-11-05 1993-12-28 Warner-Lambert Company Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5194436A (en) * 1991-01-10 1993-03-16 Hoechst-Roussel Pharmaceuticals Inc. 1-piperazinyl-2-butenes and -2-butynes
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354178A (en) * 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
ES2052675T3 (es) * 1987-11-20 1994-07-16 Hoechst Roussel Pharma 3-(4-piperazinil-sustituido en 1)butil)-4-tiazolidinonas, un procedimiento para su preparacion y su uso como medicamentos.

Also Published As

Publication number Publication date
FI94755C (fi) 1995-10-25
NO300134B1 (no) 1997-04-14
GR3026319T3 (en) 1998-06-30
EP0452850A1 (en) 1991-10-23
CZ284447B6 (cs) 1998-11-11
AR248402A1 (es) 1995-08-18
CS9101065A2 (en) 1991-11-12
IE911257A1 (en) 1991-10-23
NO911465D0 (no) 1991-04-15
HU911239D0 (en) 1991-10-28
JPH07119223B2 (ja) 1995-12-20
AU7502891A (en) 1991-10-17
FI911783A (fi) 1991-10-17
AU636972B2 (en) 1993-05-13
MX25359A (es) 1994-05-31
CA2040489A1 (en) 1991-10-17
RU2001914C1 (ru) 1993-10-30
BG60066A3 (en) 1993-09-15
JPH04234879A (ja) 1992-08-24
HUT61017A (en) 1992-11-30
FI94755B (fi) 1995-07-14
NO911465L (no) 1991-10-17
KR910018367A (ko) 1991-11-30
DK0452850T3 (da) 1998-09-23
ATE163010T1 (de) 1998-02-15
FI911783A0 (fi) 1991-04-12
DE69128845T2 (de) 1998-07-09
EP0452850B1 (en) 1998-02-04
CA2040489C (en) 2003-06-10
KR0163598B1 (ko) 1998-12-01
PL165488B1 (pl) 1994-12-30
IL97852A0 (en) 1992-06-21
US5034392A (en) 1991-07-23
ES2112844T3 (es) 1998-04-16
IL97852A (en) 1994-11-28
NZ237811A (en) 1993-12-23
DE69128845D1 (de) 1998-03-12
RO108683B1 (ro) 1994-07-29
PT97371B (pt) 1998-08-31
PT97371A (pt) 1992-01-31
PL289892A1 (en) 1992-07-27

Similar Documents

Publication Publication Date Title
IL95633A0 (en) 3-(1-substituted-4-piperazinyl)-h-indazoles,a process for their preparation and their use as medicaments
ZA904997B (en) Heteroarylamino-and heteroaryloxypridinamines and related compounds,a process for their preparation and their use as medicaments
ZA915683B (en) Substituted azoles,a process for their preparation and their use
ZA881865B (en) Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and their use as medicaments
IL94320A0 (en) N-heteroaryl-4-quinolinamines,a process for their preparation and their use as medicaments
ZA885766B (en) 1-phenyl-3-(1-piperazinyl)-1h-indazoles,a process and intermediates for their preparation,and the use thereof as medicaments
EP0424848A3 (en) Aminopyridinylaminophenols and related compounds, a process and intermediates for their preparation and their use as medicaments
GB2248838B (en) A new 5H-benzodiazepine derivative,pharmaceutical compositions containing same and process for preparing them
IL97852A0 (en) 4-(3-(4-oxothiazolidinyl))butynylamines,a process for their preparation and their use as medicaments
EP0435222A3 (en) Aminopyridinylmethanols and aminomethylpyridinamines and related compounds, a process for their preparation and their use as medicaments
ZA905045B (en) Phenoxypyridinamines and related compounds,a process for their preparation and their use as medicaments
EP0473267A3 (en) Acylaminopyridinecarboxamides, process for their preparation and their use as fungicides
ZA893374B (en) Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments
EP0435223A3 (en) Thienobenzoxepin- and naphthothiophene-derivatives, a process and intermediates for their preparation and their use as medicaments
ZA915011B (en) 2-(aminoalkyl)pyrrolealdehydes,process for their preparation and their use
IL94221A0 (en) Tetrahydroisoquino(2,1,c)(1,3)-benzodiazepines,a process for their preparation and their use as medicaments
ZA888194B (en) New acyllabdane derivatives,a process for their preparation,and their use as medicaments
ZA88409B (en) 3-methylenespiro/benzofuranpiperidines/,intermediates and a process for the preparation thereof,and their use as medicaments
ZA9010328B (en) Aminopyridinylmethanols and aminomethylpyridinamines and related compounds,a process for their preparation and their use as medicaments
ZA919790B (en) Substituted dibenz-oxa-thioconocnes,-12-oxides and 12,12-dioxides,a process for their preparation and their use in medicaments
HU913472D0 (en) New 5-(phenoxy-alkanoil-amino)-uracyl derivatives, process for their production and their medical use
ZA903830B (en) N-(aryloxyalkyl)heteroarylpiperidines and-heteroarylpiperazines,a process for their preparation and their use as medicaments
ZA916643B (en) 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and-ols,a process for their preparation and their use as medicaments
AU608300C (en) Substituted 9-amino-tetrahydroacridines and related compounds, a process for their preparation and their use as medicaments
HRP930229A2 (en) 3-aminopyrroles, process for their preparation and their use as medicaments