ZA905687B - Process for the preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride - Google Patents

Process for the preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride

Info

Publication number
ZA905687B
ZA905687B ZA905687A ZA905687A ZA905687B ZA 905687 B ZA905687 B ZA 905687B ZA 905687 A ZA905687 A ZA 905687A ZA 905687 A ZA905687 A ZA 905687A ZA 905687 B ZA905687 B ZA 905687B
Authority
ZA
South Africa
Prior art keywords
alpha
preparation
aspartyl
methyl ester
formyl
Prior art date
Application number
ZA905687A
Other languages
English (en)
Inventor
John B Hill
B Hill John
Yefim Gelman
Gelman Yefim
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of ZA905687B publication Critical patent/ZA905687B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA905687A 1988-07-14 1990-07-19 Process for the preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride ZA905687B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/219,613 US4946988A (en) 1988-07-14 1988-07-14 Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
CA002021180A CA2021180C (en) 1988-07-14 1990-07-13 Process for the preparation of .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
DD343152A DD300232A5 (de) 1988-07-14 1990-07-30 Verfahren zur Herstellung von Alpha-L-Aspartylphenylananin-Methylester-Hydrochlorid durch Verwendung isolierter N-Formyl-L-Asparagin-Anhydride
CS903874A CZ283231B6 (cs) 1988-07-14 1990-08-06 Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu
HU904906A HU210688B (en) 1988-07-14 1990-08-06 Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride
RO145705A RO108865B1 (ro) 1988-07-14 1990-08-06 Procedeu pentru prepararea clorhidratului esterului metilic al alfa-l-aspartil-l-fenilalaninei

Publications (1)

Publication Number Publication Date
ZA905687B true ZA905687B (en) 1991-07-31

Family

ID=27543426

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA905687A ZA905687B (en) 1988-07-14 1990-07-19 Process for the preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride

Country Status (18)

Country Link
US (1) US4946988A (ja)
EP (1) EP0466963B1 (ja)
JP (1) JP2609368B2 (ja)
KR (1) KR0185409B1 (ja)
CN (1) CN1035183C (ja)
AT (1) ATE130010T1 (ja)
AU (1) AU648747B2 (ja)
BR (1) BR9007648A (ja)
CA (1) CA2021180C (ja)
CZ (1) CZ283231B6 (ja)
DD (1) DD300232A5 (ja)
DK (1) DK0466963T3 (ja)
ES (1) ES2079402T3 (ja)
GR (1) GR3018046T3 (ja)
HU (1) HU210688B (ja)
RO (1) RO108865B1 (ja)
WO (1) WO1992000950A1 (ja)
ZA (1) ZA905687B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000953A1 (en) * 1988-02-12 1992-01-23 The Nutrasweet Company A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride
US5053532A (en) * 1988-02-12 1991-10-01 The Nutra Sweet Company One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
RO111571B1 (ro) * 1990-03-12 1996-11-29 Nutrasweet Company Deerefield Procedeu pentru cresterea raportului alfa / beta in reactia de cuplare aspartamica
DE60115106T2 (de) * 2000-05-18 2006-07-13 The Nutrasweet Co., Chicago Herstellung von N-[N-(3,3-Dimethylbutyl)-l-Alpha-Aspartyl]-l-Phenylalanin-1-Methylester durch Verwendung vom l-Alpha-Aspartyl-l-Phenylalanin-1-Methylester als Vorläufer
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CN103130870B (zh) * 2011-11-30 2015-03-18 江苏维多股份有限公司 α-L-天冬氨酸-L-苯丙氨酸甲酯盐酸盐的制备方法
CN102584938B (zh) * 2012-03-02 2014-02-19 孟州市华兴生物化工有限责任公司 一种阿斯巴甜的结晶方法
CN104628819B (zh) * 2014-10-23 2019-05-21 常茂生物化学工程股份有限公司 一种偶合反应生成阿斯巴甜的工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5232371B2 (ja) * 1972-07-20 1977-08-20
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
FR2295015A1 (fr) * 1974-12-18 1976-07-16 Ajinomoto Kk Procede de preparation d'esters alkyliques inferieurs d'a-l-aspartyl l-phenylalanine
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

Also Published As

Publication number Publication date
CN1035183C (zh) 1997-06-18
CA2021180A1 (en) 1992-01-14
JP2609368B2 (ja) 1997-05-14
CS387490A3 (en) 1992-02-19
EP0466963B1 (en) 1995-11-08
JPH05500364A (ja) 1993-01-28
ATE130010T1 (de) 1995-11-15
GR3018046T3 (en) 1996-02-29
CA2021180C (en) 1998-06-23
CN1058783A (zh) 1992-02-19
HUT59658A (en) 1992-06-29
AU6182090A (en) 1992-02-04
KR0185409B1 (ko) 1999-06-01
HU904906D0 (en) 1991-01-28
CZ283231B6 (cs) 1998-02-18
DD300232A5 (de) 1992-05-27
WO1992000950A1 (en) 1992-01-23
AU648747B2 (en) 1994-05-05
US4946988A (en) 1990-08-07
HU210688B (en) 1995-06-28
ES2079402T3 (es) 1996-01-16
DK0466963T3 (da) 1996-02-05
RO108865B1 (ro) 1994-09-30
KR920702341A (ko) 1992-09-03
BR9007648A (pt) 1992-09-15
EP0466963A1 (en) 1992-01-22

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