ZA895419B - Non-glycosylated,recombinant human il2 in reduced form,process for obtaining it and its use as a medicament - Google Patents

Non-glycosylated,recombinant human il2 in reduced form,process for obtaining it and its use as a medicament

Info

Publication number
ZA895419B
ZA895419B ZA895419A ZA895419A ZA895419B ZA 895419 B ZA895419 B ZA 895419B ZA 895419 A ZA895419 A ZA 895419A ZA 895419 A ZA895419 A ZA 895419A ZA 895419 B ZA895419 B ZA 895419B
Authority
ZA
South Africa
Prior art keywords
obtaining
recombinant human
reduced form
glycosylated
medicament
Prior art date
Application number
ZA895419A
Other languages
English (en)
Inventor
Danielle Lando
Lando Danielle
Philippe Riberon
Riberon Philippe
Pierre Yves Abecassis
Yves Abecassis Pierre
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA895419B publication Critical patent/ZA895419B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA895419A 1988-07-28 1989-07-17 Non-glycosylated,recombinant human il2 in reduced form,process for obtaining it and its use as a medicament ZA895419B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8810184A FR2635527B1 (fr) 1988-07-28 1988-07-28 Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament

Publications (1)

Publication Number Publication Date
ZA895419B true ZA895419B (en) 1990-09-26

Family

ID=9368873

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895419A ZA895419B (en) 1988-07-28 1989-07-17 Non-glycosylated,recombinant human il2 in reduced form,process for obtaining it and its use as a medicament

Country Status (21)

Country Link
US (2) US5874076A (da)
EP (1) EP0353150B1 (da)
JP (1) JP3016793B2 (da)
KR (1) KR0131070B1 (da)
CN (1) CN1036532C (da)
AT (1) ATE110783T1 (da)
AU (1) AU624625B2 (da)
DE (1) DE68917826T2 (da)
DK (1) DK370489A (da)
ES (1) ES2058573T3 (da)
FI (1) FI96209C (da)
FR (1) FR2635527B1 (da)
HU (1) HU207099B (da)
IE (1) IE64232B1 (da)
IL (1) IL90975A (da)
MX (1) MX16912A (da)
NZ (1) NZ230111A (da)
PT (1) PT91295B (da)
RU (1) RU2105011C1 (da)
UA (1) UA26846C2 (da)
ZA (1) ZA895419B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2660863B1 (fr) * 1990-04-17 1994-01-21 Roussel Uclaf Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour preparer une composition pharmaceutique destinee au traitement de cancers primitifs de la plevre.
FR2668368B1 (fr) * 1990-10-30 1995-03-10 Roussel Uclaf Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour preparer une composition pharmaceutique destinee au traitement des tumeurs malignes epitheliales.
ES2107449T3 (es) * 1990-11-23 1997-12-01 Roussel Uclaf Procedimiento de preparacion de una proteina elegida entre las citoquinas, que comprende al menos un puente disulfuro intramolecular por oxidacion, a un ph inferior a 5,0 de la proteina recombinante reducida correspondiente.
FR2671728B1 (fr) * 1991-01-17 1995-01-20 Roussel Uclaf Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour la preparation de compositions pharmaceutiques destinees au traitement des pneumathorax.
FR2684878B1 (fr) * 1991-12-12 1994-02-11 Roussel Uclaf Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.
US6470207B1 (en) * 1999-03-23 2002-10-22 Surgical Navigation Technologies, Inc. Navigational guidance via computer-assisted fluoroscopic imaging
US20050203578A1 (en) * 2001-08-15 2005-09-15 Weiner Michael L. Process and apparatus for treating biological organisms
RU2372356C2 (ru) * 2003-08-07 2009-11-10 Займоджинетикс, Инк. Полипептид с антивирусной активностью, его получение и применение
MX2020005041A (es) 2017-11-21 2020-10-12 Univ Leland Stanford Junior Agonistas parciales de interleucina-2.
IL294659A (en) 2020-01-14 2022-09-01 Synthekine Inc Methods and preparations of il2 skewed mutants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
US5643566A (en) * 1982-09-23 1997-07-01 Cetus Corporation Formulation processes for lipophilic proteins
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
JPS60115528A (ja) * 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
US4604377A (en) * 1984-03-28 1986-08-05 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4654830A (en) * 1984-11-27 1987-03-31 Monolithic Memories, Inc. Method and structure for disabling and replacing defective memory in a PROM
US4690915A (en) * 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
JPH0829113B2 (ja) * 1986-11-11 1996-03-27 武田薬品工業株式会社 ヒトインタ−ロイキン−２の製造法

Also Published As

Publication number Publication date
ES2058573T3 (es) 1994-11-01
HU207099B (en) 1993-03-01
EP0353150B1 (fr) 1994-08-31
AU3902489A (en) 1990-02-01
FI893587A (fi) 1990-01-29
DK370489A (da) 1990-01-29
RU2105011C1 (ru) 1998-02-20
US5874076A (en) 1999-02-23
JPH02209896A (ja) 1990-08-21
CN1036532C (zh) 1997-11-26
FI96209B (fi) 1996-02-15
IE892443L (en) 1990-01-28
CN1042377A (zh) 1990-05-23
DE68917826D1 (de) 1994-10-06
IL90975A0 (en) 1990-02-09
IE64232B1 (en) 1995-07-26
MX16912A (es) 1993-10-01
HUT51647A (en) 1990-05-28
FI96209C (fi) 1996-05-27
FR2635527B1 (fr) 1992-06-12
AU624625B2 (en) 1992-06-18
JP3016793B2 (ja) 2000-03-06
UA26846C2 (uk) 1999-12-29
EP0353150A1 (fr) 1990-01-31
PT91295B (pt) 1995-03-01
KR0131070B1 (ko) 1998-04-11
NZ230111A (en) 1992-04-28
PT91295A (pt) 1990-02-08
FR2635527A1 (fr) 1990-02-23
DE68917826T2 (de) 1995-01-12
KR900001854A (ko) 1990-02-27
US5814314A (en) 1998-09-29
DK370489D0 (da) 1989-07-27
FI893587A0 (fi) 1989-07-27
ATE110783T1 (de) 1994-09-15
IL90975A (en) 1994-11-28

Similar Documents

Publication Publication Date Title
SG52690A1 (en) Process for the production of biologically active protein (e.g. tgf)
GEP20074095B (en) Analogs of human insulin modified at position 29 of the b chain thereof
ATE33503T1 (de) Pharmazeutische und tiermedizinische praeparate von interleukin-2, in dem cystein-125 ausgetauscht worden ist (muteine), sowie deren herstellung.
DE69032679D1 (de) Threo (2R, 3S)-3-amino-2-hydroxypentansäure und threo (2R,3S)-3-(p-methoxy-benzyloxycarbonyl/FMOC) amino-2-hydroxy-pentansäure
HU9200548D0 (en) Improved activity process of recombined proteins
HK1002901A1 (en) A composition used as a therapeutic agent against chronic viral hepatic diseases
ZA895419B (en) Non-glycosylated,recombinant human il2 in reduced form,process for obtaining it and its use as a medicament
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
BR9007115A (pt) Novo trombolitico
MC1847A1 (fr) Fragments d'interferons imnuns recombinants,homogenes et composition pharmaceutiques les contenant
DE69106407D1 (de) Verfahren zur Herstellung von rekombinantem menschlichem gamma-Interferon ohne Cystein und ohne Methionin am N-Terminal.
DE3886517D1 (de) Menschlicher Prourokinase ähnliches Polypeptid.
IT8747551A0 (it) 8 alfa acilamminoergoline ,loro preparazione e loro impiego come medicamenti
HU9200147D0 (en) Medical preparations with human interleukin-2 content
DE3687448D1 (de) Verwendung von 6h-7,8-dihydrothiapyrano(3,2d)pyrimidinen zur herstellung von arzneimitteln zur verwendung als hypoglykaemische mittel oder als abmagerungsmittel fuer fettsuechtige patienten.
ATE92106T1 (de) Polypeptid und dessen herstellung.
ATE98990T1 (de) Menschlicher prourokinase aehnliches polypeptid.