ZA893696B - Enantiomeric glutaramide diuretic agents - Google Patents

Enantiomeric glutaramide diuretic agents

Info

Publication number
ZA893696B
ZA893696B ZA893696A ZA893696A ZA893696B ZA 893696 B ZA893696 B ZA 893696B ZA 893696 A ZA893696 A ZA 893696A ZA 893696 A ZA893696 A ZA 893696A ZA 893696 B ZA893696 B ZA 893696B
Authority
ZA
South Africa
Prior art keywords
enantiomeric
diuretic agents
glutaramide
glutaramide diuretic
agents
Prior art date
Application number
ZA893696A
Other languages
English (en)
Inventor
John Christopher Danilewicz
Christopher Danilewicz John
Michael Trevelyan Williams
Trevelyan Williams Michael
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA893696B publication Critical patent/ZA893696B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
ZA893696A 1988-05-19 1989-05-17 Enantiomeric glutaramide diuretic agents ZA893696B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888811873A GB8811873D0 (en) 1988-05-19 1988-05-19 Therapeutic agents

Publications (1)

Publication Number Publication Date
ZA893696B true ZA893696B (en) 1990-12-28

Family

ID=10637176

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893696A ZA893696B (en) 1988-05-19 1989-05-17 Enantiomeric glutaramide diuretic agents

Country Status (29)

Country Link
EP (1) EP0342850B1 (de)
JP (1) JPH072699B2 (de)
KR (1) KR920000561B1 (de)
CN (1) CN1015361B (de)
AT (1) ATE76399T1 (de)
AU (1) AU602813B2 (de)
CA (1) CA1331197C (de)
CS (1) CS274502B2 (de)
DD (1) DD283772A5 (de)
DE (1) DE68901582D1 (de)
DK (1) DK172032B1 (de)
EG (1) EG19007A (de)
ES (1) ES2037418T3 (de)
FI (1) FI93541C (de)
GB (1) GB8811873D0 (de)
GR (1) GR3004968T3 (de)
HU (1) HU205067B (de)
IE (1) IE60724B1 (de)
IL (1) IL90267A (de)
MX (1) MX16067A (de)
MY (1) MY104735A (de)
NO (1) NO173647C (de)
NZ (1) NZ229186A (de)
PH (1) PH26740A (de)
PL (1) PL154813B1 (de)
PT (1) PT90584B (de)
SU (1) SU1766251A3 (de)
YU (1) YU47973B (de)
ZA (1) ZA893696B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8812597D0 (en) * 1988-05-27 1988-06-29 Pfizer Ltd Therapeutic agents
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
GB9000725D0 (en) * 1990-01-12 1990-03-14 Pfizer Ltd Therapeutic agents
DE69300826T2 (de) * 1993-09-22 1996-04-18 Pfizer Research And Development Co., N.V./S.A., Dublin Hydrierung.
US7468390B2 (en) 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
CN108685889A (zh) 2012-08-24 2018-10-23 诺华股份有限公司 用于治疗特征为心房增大或重构的疾病的nep抑制剂
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
US20180311241A1 (en) 2015-10-29 2018-11-01 Cadila Healthcare Limited Pharmaceutical synergistic combination

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제

Also Published As

Publication number Publication date
GB8811873D0 (en) 1988-06-22
ATE76399T1 (de) 1992-06-15
IL90267A0 (en) 1989-12-15
JPH072699B2 (ja) 1995-01-18
CN1015361B (zh) 1992-02-05
PH26740A (en) 1992-09-28
ES2037418T3 (es) 1993-06-16
KR900017993A (ko) 1990-12-20
PT90584A (pt) 1989-11-30
FI892386A0 (fi) 1989-05-18
GR3004968T3 (de) 1993-04-28
CS274502B2 (en) 1991-04-11
EP0342850A1 (de) 1989-11-23
MX16067A (es) 1993-10-01
YU102289A (en) 1991-06-30
EP0342850B1 (de) 1992-05-20
CA1331197C (en) 1994-08-02
NO173647C (no) 1994-01-12
AU3490489A (en) 1989-11-23
YU47973B (sh) 1996-08-13
NO173647B (no) 1993-10-04
FI93541C (fi) 1995-04-25
NO892002L (no) 1989-11-20
DE68901582D1 (de) 1992-06-25
IL90267A (en) 1993-08-18
HUT53596A (en) 1990-11-28
NO892002D0 (no) 1989-05-18
PL154813B1 (en) 1991-09-30
FI93541B (fi) 1995-01-13
FI892386A (fi) 1989-11-20
NZ229186A (en) 1990-10-26
DD283772A5 (de) 1990-10-24
DK240889A (da) 1989-11-20
HU205067B (en) 1992-03-30
CN1037704A (zh) 1989-12-06
JPH0222256A (ja) 1990-01-25
IE891613L (en) 1989-11-19
IE60724B1 (en) 1994-08-10
AU602813B2 (en) 1990-10-25
SU1766251A3 (ru) 1992-09-30
PT90584B (pt) 1994-09-30
EG19007A (en) 1994-11-30
KR920000561B1 (ko) 1992-01-16
MY104735A (en) 1994-05-31
CS296589A2 (en) 1990-09-12
DK240889D0 (da) 1989-05-18
PL279491A1 (en) 1989-11-27
DK172032B1 (da) 1997-09-22

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