ZA891623B - 6-substituted purinyl piperazine derivatives - Google Patents

6-substituted purinyl piperazine derivatives

Info

Publication number
ZA891623B
ZA891623B ZA891623A ZA891623A ZA891623B ZA 891623 B ZA891623 B ZA 891623B ZA 891623 A ZA891623 A ZA 891623A ZA 891623 A ZA891623 A ZA 891623A ZA 891623 B ZA891623 B ZA 891623B
Authority
ZA
South Africa
Prior art keywords
piperazine derivatives
substituted purinyl
purinyl piperazine
derivatives
substituted
Prior art date
Application number
ZA891623A
Other languages
English (en)
Inventor
Zoltan G Hajos
G Hajos Zoltan
Ramesh M Kanojia
M Kanojia Ramesh
Jeffrey B Press
B Press Jeffrey
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of ZA891623B publication Critical patent/ZA891623B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA891623A 1988-03-03 1989-03-02 6-substituted purinyl piperazine derivatives ZA891623B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/163,487 US4876257A (en) 1988-03-03 1988-03-03 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

Publications (1)

Publication Number Publication Date
ZA891623B true ZA891623B (en) 1990-11-28

Family

ID=22590215

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA891623A ZA891623B (en) 1988-03-03 1989-03-02 6-substituted purinyl piperazine derivatives

Country Status (20)

Country Link
US (1) US4876257A (fr)
EP (1) EP0331511B1 (fr)
JP (1) JPH0826019B2 (fr)
KR (1) KR940002822B1 (fr)
CN (1) CN1031056C (fr)
AT (1) ATE92067T1 (fr)
AU (1) AU614583B2 (fr)
DE (1) DE68907750T2 (fr)
DK (1) DK101589A (fr)
ES (1) ES2059724T3 (fr)
FI (1) FI92587C (fr)
HU (1) HU205760B (fr)
IE (1) IE63457B1 (fr)
IL (1) IL89458A (fr)
MY (1) MY104959A (fr)
NO (1) NO171500C (fr)
NZ (1) NZ228167A (fr)
PH (1) PH26971A (fr)
PT (1) PT89903B (fr)
ZA (1) ZA891623B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
AU648070B2 (en) * 1990-04-23 1994-04-14 Ortho Pharmaceutical Corporation Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
NZ237766A (en) 1990-04-23 1993-03-26 Ortho Pharma Corp Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates
US5215987A (en) * 1990-04-23 1993-06-01 Ortho Pharmaceutical Corporation Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
US5252569A (en) * 1990-05-23 1993-10-12 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
NZ238122A (en) * 1990-05-23 1994-01-26 Ortho Pharma Corp 6-substituted purinyl piperazine derivatives and pharmaceutical
ATE206119T1 (de) * 1992-02-13 2001-10-15 Merrell Pharma Inc Thiacyclische piperidinylderivate
US5463061A (en) * 1992-05-15 1995-10-31 Mitsui Toatsu Chemicals, Incorporated Process for production of glycide derivative
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
EP0930307B1 (fr) * 1996-09-18 2002-12-04 Daiso Co., Ltd. Procede de preparation d'ethers glycidyliques
EP0930291B1 (fr) * 1996-09-18 2002-08-14 Daiso Co., Ltd. Procede de preparation d'ethers 3-amino-2-hydroxy-1-propyliques
ATE311884T1 (de) * 1997-07-12 2005-12-15 Cancer Rec Tech Ltd Cyclin-abhängige-kinase inhibierende purinderivate
KR20030025153A (ko) * 2001-09-19 2003-03-28 이보섭 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
CA2513529A1 (fr) * 2003-01-17 2004-08-19 Cv Therapeutics Inc. Composes heterocycliques substitues utiles pour le traitement de maladies cardio-vasculaires
KR20240135687A (ko) 2017-06-20 2024-09-11 임브리아 파마슈티칼스, 인크. 심장 대사의 효율을 증가시키기 위한 조성물 및 방법
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238207A (en) * 1960-03-01 1966-03-01 Burroughs Wellcome Co 6-oxyorganopurines and method of preparing them
US3232937A (en) * 1962-08-02 1966-02-01 Burroughs Wellcome Co 6-benzylmercaptopurines
US3135754A (en) * 1962-08-09 1964-06-02 Burroughs Wellcome Co Purine derivatives
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) * 1966-11-25 1970-02-26 Troponwerke Dinklage & Co Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
GB1289287A (fr) * 1969-03-28 1972-09-13
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
US4189579A (en) * 1977-05-20 1980-02-19 The Dow Chemical Company Aminoalkylthiopurines
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
EP0087810B1 (fr) * 1982-03-02 1986-06-25 Eisai Co., Ltd. Composés pharmaceutiques antiphlogistique/antipyrétique/analgésique contenant des dérivés de théophylline comme ingrédient actif
DK157135C (da) * 1982-04-07 1990-04-02 Pfizer Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DE3703633A1 (de) * 1986-02-14 1987-08-20 Sandoz Ag Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4710572A (en) * 1986-07-30 1987-12-01 American Home Products Corporation Histamine H1 antagonists

Also Published As

Publication number Publication date
NO890893L (no) 1989-09-04
FI891003A (fi) 1989-09-04
CN1031056C (zh) 1996-02-21
NO890893D0 (no) 1989-03-02
EP0331511A1 (fr) 1989-09-06
FI92587C (fi) 1994-12-12
JPH01279887A (ja) 1989-11-10
ES2059724T3 (es) 1994-11-16
AU614583B2 (en) 1991-09-05
JPH0826019B2 (ja) 1996-03-13
HU205760B (en) 1992-06-29
PH26971A (en) 1992-12-28
IE890684L (en) 1989-09-03
CN1036765A (zh) 1989-11-01
FI891003A0 (fi) 1989-03-02
EP0331511B1 (fr) 1993-07-28
FI92587B (fi) 1994-08-31
PT89903B (pt) 1994-05-31
IL89458A0 (en) 1989-09-10
AU3088289A (en) 1989-09-07
IL89458A (en) 1993-07-08
KR890014538A (ko) 1989-10-24
NO171500B (no) 1992-12-14
HUT49352A (en) 1989-09-28
DK101589D0 (da) 1989-03-02
DE68907750T2 (de) 1994-01-05
DK101589A (da) 1989-09-04
IE63457B1 (en) 1995-04-19
MY104959A (en) 1994-07-30
DE68907750D1 (de) 1993-09-02
US4876257A (en) 1989-10-24
KR940002822B1 (ko) 1994-04-04
NZ228167A (en) 1991-08-27
ATE92067T1 (de) 1993-08-15
NO171500C (no) 1993-03-24
PT89903A (pt) 1989-11-10

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