ZA887157B - Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides - Google Patents
Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamidesInfo
- Publication number
- ZA887157B ZA887157B ZA887157A ZA887157A ZA887157B ZA 887157 B ZA887157 B ZA 887157B ZA 887157 A ZA887157 A ZA 887157A ZA 887157 A ZA887157 A ZA 887157A ZA 887157 B ZA887157 B ZA 887157B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzamides
- piperidinyl
- hydroxy
- alkyl
- novel substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10111587A | 1987-09-25 | 1987-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA887157B true ZA887157B (en) | 1990-05-30 |
Family
ID=22283104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA887157A ZA887157B (en) | 1987-09-25 | 1988-09-23 | Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0309043B1 (no) |
| JP (1) | JP2830936B2 (no) |
| KR (1) | KR0124054B1 (no) |
| CN (2) | CN1021652C (no) |
| AT (1) | ATE113936T1 (no) |
| AU (1) | AU610241B2 (no) |
| BG (1) | BG60560B1 (no) |
| CA (1) | CA1317940C (no) |
| DE (1) | DE3852085T2 (no) |
| DK (1) | DK529888A (no) |
| ES (1) | ES2066781T3 (no) |
| FI (1) | FI94129C (no) |
| GR (1) | GR3014972T3 (no) |
| HU (1) | HU203724B (no) |
| IE (1) | IE64980B1 (no) |
| IL (1) | IL87847A0 (no) |
| MA (1) | MA21381A1 (no) |
| NO (1) | NO172580C (no) |
| NZ (1) | NZ226125A (no) |
| PH (1) | PH25504A (no) |
| PT (1) | PT88577B (no) |
| SU (1) | SU1625331A3 (no) |
| TN (1) | TNSN88096A1 (no) |
| ZA (1) | ZA887157B (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ225152A (en) * | 1987-07-17 | 1990-04-26 | Janssen Pharmaceutica Nv | Heterocyclically substituted piperidinyl benzamides as pharmaceuticals |
| US5019583A (en) * | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| GB9005014D0 (en) | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| US5438064A (en) * | 1991-12-23 | 1995-08-01 | American Home Products Corporation | Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents |
| TW294595B (no) * | 1992-11-20 | 1997-01-01 | Janssen Pharmaceutica Nv | |
| JP3719612B2 (ja) * | 1993-06-14 | 2005-11-24 | 塩野義製薬株式会社 | ヘテロ環を含有する尿素誘導体 |
| BR9509036A (pt) * | 1994-09-27 | 1997-10-14 | Janssen Pharmaceutica Nv | Derivados biciclicos de benzoato de peperidinila n-substituída |
| CA2200579C (en) * | 1994-09-27 | 2006-07-04 | Georges Henri Paul Van Daele (Deceased) | Phenyl-oxo-alkyl-(4-piperidinyl)benzoate derivatives as colon motility enhancing agents |
| US6096761A (en) * | 1996-02-15 | 2000-08-01 | Janssen Pharmaceutica N.V. | Esters of 3-hydroxy-piperidinemethanol derivatives |
| NZ330263A (en) * | 1996-02-15 | 1999-06-29 | Janssen Pharmaceutica Nv | Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying |
| TW548103B (en) | 1997-07-11 | 2003-08-21 | Janssen Pharmaceutica Nv | Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| CN1076173C (zh) * | 1998-05-29 | 2001-12-19 | 孙国文 | 香身茶剂 |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| US6552046B2 (en) * | 2000-06-07 | 2003-04-22 | Aryx Therapeutics | Materials and methods for the treatment of gastroesophageal reflux disease |
| GB0211230D0 (en) | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| US8138204B2 (en) | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| DK2194053T3 (da) | 2004-01-07 | 2013-07-01 | Armetheon Inc | Methoxypiperidinderivater til brug i behandling af gastrointestinale forstyrrelser og forstyrrelser i centralnervesystemet. |
| US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| KR101351454B1 (ko) | 2005-08-31 | 2014-01-14 | 아메데온, 인코포레이티드 | 위장 및 중추 신경계 장애의 치료에 유용한 입체이성질체 화합물의 합성 방법 및 중간 생성물 |
| US20080085915A1 (en) * | 2006-06-23 | 2008-04-10 | Cyrus Becker | Compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| KR100976063B1 (ko) * | 2007-03-16 | 2010-08-17 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법 |
| CA2756871A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| MX2013002409A (es) * | 2010-09-01 | 2013-04-03 | Janssen Pharmaceutica Nv | Antagonistas del receptor 5-ht2b. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| ZW12187A1 (en) * | 1986-07-03 | 1989-02-01 | Janssen Pharmaceutica Nv | 4-(aroylamino)piperidinebutanamide derivatives |
| NZ225152A (en) * | 1987-07-17 | 1990-04-26 | Janssen Pharmaceutica Nv | Heterocyclically substituted piperidinyl benzamides as pharmaceuticals |
-
1988
- 1988-09-06 CA CA000576546A patent/CA1317940C/en not_active Expired - Fee Related
- 1988-09-09 NZ NZ226125A patent/NZ226125A/xx unknown
- 1988-09-15 EP EP88202011A patent/EP0309043B1/en not_active Expired - Lifetime
- 1988-09-15 DE DE3852085T patent/DE3852085T2/de not_active Expired - Fee Related
- 1988-09-15 AT AT88202011T patent/ATE113936T1/de not_active IP Right Cessation
- 1988-09-15 ES ES88202011T patent/ES2066781T3/es not_active Expired - Lifetime
- 1988-09-19 AU AU22322/88A patent/AU610241B2/en not_active Ceased
- 1988-09-21 MA MA21626A patent/MA21381A1/fr unknown
- 1988-09-22 NO NO884208A patent/NO172580C/no unknown
- 1988-09-23 SU SU884356607A patent/SU1625331A3/ru active
- 1988-09-23 IL IL87847A patent/IL87847A0/xx not_active IP Right Cessation
- 1988-09-23 ZA ZA887157A patent/ZA887157B/xx unknown
- 1988-09-23 IE IE288988A patent/IE64980B1/en not_active IP Right Cessation
- 1988-09-23 PH PH37582A patent/PH25504A/en unknown
- 1988-09-23 PT PT88577A patent/PT88577B/pt not_active IP Right Cessation
- 1988-09-23 FI FI884375A patent/FI94129C/fi not_active IP Right Cessation
- 1988-09-23 HU HU884991A patent/HU203724B/hu not_active IP Right Cessation
- 1988-09-23 TN TNTNSN88096A patent/TNSN88096A1/fr unknown
- 1988-09-23 BG BG85500A patent/BG60560B1/bg unknown
- 1988-09-23 DK DK529888A patent/DK529888A/da not_active Application Discontinuation
- 1988-09-24 CN CN88106959A patent/CN1021652C/zh not_active Expired - Fee Related
- 1988-09-24 JP JP63237547A patent/JP2830936B2/ja not_active Expired - Lifetime
- 1988-09-27 KR KR1019880012475A patent/KR0124054B1/ko not_active IP Right Cessation
-
1992
- 1992-07-10 CN CN92105871A patent/CN1067889A/zh active Pending
-
1995
- 1995-02-08 GR GR940403606T patent/GR3014972T3/el unknown
Also Published As
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| GR3014972T3 (en) | Novel substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides. | |
| ZA902188B (en) | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran,dihydro-2h-benzopyran or dihydrobenzodioxin)carboxamide derivatives | |
| ES8602763A1 (es) | Un procedimiento para la preparacion de n-(heterociclilbiciclo)-4-piperidinaminas. | |
| IL66916A (en) | N-(3-hydroxy-4-piperidinyl)benzamide derivatives,their preparation and pharmaceutical compositions containing them | |
| IL78487A (en) | Substituted n-((4-piperidinyl)alkyl)bicyclic condensed oxazol-and thiazolamines,their preparation and pharmaceutical compositions containing them |