ZA862945B - Transdermal nitroglycerin delivery system - Google Patents

Transdermal nitroglycerin delivery system

Info

Publication number
ZA862945B
ZA862945B ZA862945A ZA862945A ZA862945B ZA 862945 B ZA862945 B ZA 862945B ZA 862945 A ZA862945 A ZA 862945A ZA 862945 A ZA862945 A ZA 862945A ZA 862945 B ZA862945 B ZA 862945B
Authority
ZA
South Africa
Prior art keywords
sensitive adhesive
pressure
tape
delivery system
nitroglycerin
Prior art date
Application number
ZA862945A
Other languages
English (en)
Inventor
Steven Marshall Wick
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of ZA862945B publication Critical patent/ZA862945B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA862945A 1985-04-19 1986-04-18 Transdermal nitroglycerin delivery system ZA862945B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/725,215 US4751087A (en) 1985-04-19 1985-04-19 Transdermal nitroglycerin delivery system

Publications (1)

Publication Number Publication Date
ZA862945B true ZA862945B (en) 1987-12-30

Family

ID=24913627

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA862945A ZA862945B (en) 1985-04-19 1986-04-18 Transdermal nitroglycerin delivery system

Country Status (14)

Country Link
US (1) US4751087A (de)
EP (1) EP0219539B1 (de)
JP (1) JP2588180B2 (de)
AT (1) ATE76736T1 (de)
AU (1) AU593810B2 (de)
CA (1) CA1273871A (de)
CZ (1) CZ390591A3 (de)
DE (1) DE3685545T2 (de)
ES (1) ES8802370A1 (de)
IE (1) IE59725B1 (de)
IL (1) IL78527A (de)
NZ (1) NZ215746A (de)
WO (1) WO1986006281A1 (de)
ZA (1) ZA862945B (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5422118A (en) * 1986-11-07 1995-06-06 Pure Pac, Inc. Transdermal administration of amines with minimal irritation and high transdermal flux rate
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
JPH0696529B2 (ja) * 1987-03-31 1994-11-30 積水化学工業株式会社 ニトログリセリン貼付剤およびその製造方法
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5223261A (en) * 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
AU630347B2 (en) * 1988-02-26 1992-10-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US4994278A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Breathable backing
US5300291A (en) * 1988-03-04 1994-04-05 Noven Pharmaceuticals, Inc. Method and device for the release of drugs to the skin
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
DE3823070A1 (de) * 1988-07-07 1990-02-22 Kettelhack Riker Pharma Gmbh Selbstklebendes heftpflaster
DE68920109T2 (de) * 1988-10-11 1995-05-11 Shire Holdings Ltd Arzneimittelpräparat für perkutane Absorption.
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5238944A (en) * 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US5736553A (en) * 1988-12-15 1998-04-07 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo 4,5-C!quinolin-4-amine
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
US5204109A (en) * 1989-12-28 1993-04-20 Nitto Denko Corporation Percutaneous gel preparation
DE69026361T2 (de) * 1989-12-28 1996-08-14 Nitto Denko Corp Gelpräparat für die perkutane Verabreichung
US5057500A (en) * 1990-02-12 1991-10-15 Dermatologic Research Corporation Treatment of pruritis with esters and amides
JP2820306B2 (ja) * 1990-02-27 1998-11-05 積水化学工業株式会社 経皮吸収製剤
JPH07116032B2 (ja) * 1990-04-06 1995-12-13 積水化学工業株式会社 ニトログリセリン貼付剤
CA2039586A1 (en) * 1990-05-02 1991-11-03 Marian R. Appelt Crosslinked pressure-sensitive adhesives tolerant of alcohol-based excipients used in transdermal delivery devices and method of preparing same
GB9021674D0 (en) * 1990-10-05 1990-11-21 Ethical Pharma Ltd Transdermal device
US5122383A (en) * 1991-05-17 1992-06-16 Theratech, Inc. Sorbitan esters as skin permeation enhancers
US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
ATE126434T1 (de) * 1991-06-10 1995-09-15 Sanol Arznei Schwarz Gmbh Nitroglycerin-pflaster und verfahren zu seiner herstellung.
US5273756A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
US5234690A (en) * 1991-08-23 1993-08-10 Cygnus Therapeutic Systems Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
US5273755A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset
US5278192A (en) * 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
JP2539330B2 (ja) * 1993-05-11 1996-10-02 日東電工株式会社 医療用粘着剤及びこれを用いて形成された医療用外用材
EP0707465A4 (de) * 1993-07-08 1997-04-16 Cygnus Therapeutic Systems Monolithisches matrix transdermales abgabesystem
US5385736A (en) * 1993-07-12 1995-01-31 Minnesota Mining And Manufacturing Company Transdermal melatonin delivery system
US5494680A (en) * 1993-12-08 1996-02-27 Minnesota Mining And Manufacturing Company Transdermal delivery device
GB2292520B (en) * 1994-08-25 1998-09-02 Univ Sheffield Transdermal dressings for animals
AU702593B2 (en) * 1994-09-14 1999-02-25 Minnesota Mining And Manufacturing Company Matrix for transdermal drug delivery
JP3604177B2 (ja) * 1994-09-14 2004-12-22 日東電工株式会社 経皮吸収製剤
US5702720A (en) * 1995-12-22 1997-12-30 Minnesota Mining And Manufacturing Company Transdermal device for the delivery of flurbiprofen
AU732803B2 (en) * 1996-01-17 2001-05-03 National Starch And Chemical Investment Holding Corporation Adhesives resistant to skin-penetration enhancers
JP3628809B2 (ja) * 1996-06-10 2005-03-16 アルケア株式会社 薬剤徐放性医療用配合物及びその製造方法
JP2002505676A (ja) 1997-06-23 2002-02-19 クイーンズ ユニバーシティー アット キングストン 微量投与療法
JP2001517493A (ja) 1997-09-26 2001-10-09 ノーヴェン ファーマシューティカルズ インコーポレイテッド 生体接着剤組成物及び活性薬剤の局所投与方法
US20040018241A1 (en) * 1997-09-26 2004-01-29 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
WO1999032153A1 (en) * 1997-12-22 1999-07-01 Alza Corporation Monoglyceride and ethyl palmitate permeation enhancer compositions
DE19818955C2 (de) * 1998-04-28 2000-06-29 Lohmann Therapie Syst Lts Zusammensetzung, enthaltend Polyacrylat, Polyterpen, Nitroglycerin und wahlweise Polyvinylacetat
DE19830648A1 (de) * 1998-07-09 2000-01-13 Lohmann Therapie Syst Lts Glyceroltrinitrathaltige Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung
US6160086A (en) * 1998-07-30 2000-12-12 3M Innovative Properties Company Process for removing impurities from polymers
DE69933775T2 (de) * 1998-08-20 2007-10-04 3M Innovative Properties Co., St. Paul Sprühverband und wirkstoffabgabesystem
US6383511B1 (en) * 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
AU2002232471A1 (en) * 2000-10-31 2002-05-15 Nutrition 21, Inc. Methods and compositions for the treatment of polycystic ovary syndrome with chromium complexes
US6682757B1 (en) 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US7799827B2 (en) 2002-03-08 2010-09-21 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
IL166687A0 (en) 2002-08-30 2006-01-15 Alza Corp Embossable and writable multilaminate backing construction
JP3809462B2 (ja) * 2003-06-24 2006-08-16 埼玉第一製薬株式会社 医療用経皮吸収テープ製剤用非水性粘着剤並びに医療用経皮吸収テープ製剤およびその製造法
DE10340428B4 (de) 2003-09-02 2015-02-12 Acino Ag Opioides Analgetikum enthaltende transdermale Formulierung
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
CN1905866B (zh) * 2004-01-20 2011-01-05 尼普洛外用药品株式会社 妥洛特罗贴剂
WO2005123173A1 (en) 2004-06-10 2005-12-29 3M Innovative Properties Company Patch application device and kit
WO2006017632A1 (en) * 2004-08-04 2006-02-16 Cassel Douglas R An analgesic patch for sports injury and rehabilitation medicine and method to alleviate pain
CN101044169A (zh) * 2004-10-19 2007-09-26 3M创新有限公司 生产压敏粘合剂的方法
CA2588943C (en) 2004-12-15 2013-02-26 Saitama Daiichi Pharmaceutical Co., Ltd. Medical tape preparation
US8080560B2 (en) * 2004-12-17 2011-12-20 3M Innovative Properties Company Immune response modifier formulations containing oleic acid and methods
US20060223786A1 (en) * 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
GT200600396A (es) * 2005-09-07 2007-04-23 Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales
US8889154B2 (en) 2005-09-15 2014-11-18 Medicis Pharmaceutical Corporation Packaging for 1-(2-methylpropyl)-1H-imidazo[4,5-c] quinolin-4-amine-containing formulation
US20070259026A1 (en) * 2006-04-20 2007-11-08 Robert Ang Vasodialating dressing for use with intravenous catheters
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
US20100092401A1 (en) * 2006-07-18 2010-04-15 Graceway Pharmaceuticals, Llc Immune response modifier formulations
AU2007279376B2 (en) * 2006-07-31 2012-09-06 Wirra Ip Pty Ltd Immune response modifier compositions and methods
JP5389668B2 (ja) 2007-01-31 2014-01-15 チョンシー ユー 皮膚浸透率の非常に高い1H−イミダゾ[4,5−c]キノリン−4−アミン及び関連化合物の正に荷電した水溶性プロドラッグ
DE102007021549A1 (de) 2007-05-08 2008-11-13 Novosis Ag Transdermales therapeutisches System enthaltend mindestens zwei Opioide
US20090304776A1 (en) * 2008-06-06 2009-12-10 Totada Shantha Transmucosal delivery of therapeutic agents and methods of use thereof
US7883487B2 (en) * 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
US20100160368A1 (en) 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
SI2378876T1 (sl) 2008-12-19 2019-05-31 Medicis Pharmaceutical Corporation Formulacije z nižjo dozirno jakostjo imikvimoda in kratki odmerni režimi za zdravljenje aktinične keratoze
EA025993B1 (ru) 2009-07-13 2017-02-28 Медисис Фармасьютикал Корпорейшн Композиции с более низким содержанием имиквимода и короткие режимы дозирования для лечения остроконечных и перианальных бородавок
EP2476414B1 (de) * 2009-09-07 2015-03-04 NIPRO Patch Co., Ltd. Transdermal absorbierbares präparat
DK2584900T3 (en) 2010-06-25 2019-04-01 Medicis Pharmaceutical Corp Combination therapy with cryosurgery and low-dose imiquimod for the treatment of actinic keratosis
US9849270B2 (en) 2011-12-16 2017-12-26 3M Innovative Properties Company Foldable adhesive composite dressing
JP6576039B2 (ja) 2011-12-21 2019-09-18 スリーエム イノベイティブ プロパティズ カンパニー オーバーレイライナを有する粘着パッチ組立体、並びにそれを作製するためのシステム及び方法
EP2793869B1 (de) 2011-12-21 2015-09-23 3M Innovative Properties Company Transdermales haftpflaster mit einem abnehmbaren mikronadelfeld und verwendungsverfahren dafür
US20140004204A1 (en) * 2012-06-29 2014-01-02 University Of South Florida Biocompatible polyacrylate compositions and methods of use
EP2906284B8 (de) 2012-10-10 2021-01-20 Kindeva Drug Delivery L.P. Kraftgesteuerter applikator zum auftragen einer mikronadelvorrichtung auf der haut
EP2919849B1 (de) 2012-11-16 2021-01-06 Kindeva Drug Delivery L.P. Kraftgesteuerter applikator zum auftragen einer mikronadelvorrichtung auf der haut
JP2016517707A (ja) 2013-03-22 2016-06-20 スリーエム イノベイティブ プロパティズ カンパニー カウンタ組立体を備えているマイクロニードルアプリケータ
US9895520B2 (en) 2013-05-31 2018-02-20 3M Innovative Properties Company Microneedle injection apparatus comprising a dual cover
WO2014193725A1 (en) 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection and infusion apparatus and method of using same
MX353241B (es) 2013-05-31 2018-01-05 3M Innovative Properties Co Aparato de inyección de microagujas que comprende un accionador invertido.
WO2015023649A2 (en) 2013-08-12 2015-02-19 3M Innovative Properties Company Peptides for enhancing transdermal delivery
EP3020398A1 (de) 2014-11-17 2016-05-18 Nitto Denko Corporation Verbindungen und Zusammensetzungen zur Verminderung von Narbenbildung
EP3411023A1 (de) 2016-02-05 2018-12-12 3M Innovative Properties Company Transdermale wirkstofffreisetzungssysteme mit fluorsilikontrennschichten
EP3287462A1 (de) 2016-08-25 2018-02-28 Nitto Denko Corporation Isosorbid-derivate zur behandlung von bakteriellen filme

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
DE2528516A1 (de) * 1974-07-05 1976-01-22 Sandoz Ag Neue galenische zubereitung
DE2920500A1 (de) * 1979-05-21 1980-11-27 Boehringer Sohn Ingelheim Pharmazeutische zubereitung in form eines polyacrylatfilmes
JPS5777617A (en) * 1980-10-20 1982-05-15 Nichiban Co Ltd Plaster for cardiac disease
JPS5843368B2 (ja) * 1980-10-30 1983-09-27 日東電工株式会社 消炎鎮痛貼付剤
JPS6059207B2 (ja) * 1981-03-13 1985-12-24 日東電工株式会社 複合製剤の製法
JPS58913A (ja) * 1981-06-26 1983-01-06 Nitto Electric Ind Co Ltd 局所系医薬製剤
US4542013A (en) * 1981-07-08 1985-09-17 Key Pharmaceuticals, Inc. Trinitroglycerol sustained release vehicles and preparation therefrom
US4585452A (en) * 1983-04-12 1986-04-29 Key Pharmaceuticals, Inc. Transdermal systemic dosage forms
JPS59199628A (ja) * 1983-04-25 1984-11-12 Sekisui Chem Co Ltd 貼付剤
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
ATE59302T1 (de) * 1984-07-24 1991-01-15 Key Pharma Klebende schicht zur transdermalen freigabe.

Also Published As

Publication number Publication date
JPS62502965A (ja) 1987-11-26
JP2588180B2 (ja) 1997-03-05
EP0219539A1 (de) 1987-04-29
IE861035L (en) 1986-10-19
NZ215746A (en) 1989-08-29
ATE76736T1 (de) 1992-06-15
US4751087A (en) 1988-06-14
IE59725B1 (en) 1994-03-23
IL78527A (en) 1991-07-18
DE3685545D1 (de) 1992-07-09
CZ390591A3 (en) 1993-07-14
ES554144A0 (es) 1988-05-16
ES8802370A1 (es) 1988-05-16
CA1273871A (en) 1990-09-11
WO1986006281A1 (en) 1986-11-06
AU5772586A (en) 1986-11-18
DE3685545T2 (de) 1992-12-24
EP0219539B1 (de) 1992-06-03
US4751087B1 (de) 1993-03-02
AU593810B2 (en) 1990-02-22
IL78527A0 (en) 1986-08-31

Similar Documents

Publication Publication Date Title
US4751087B1 (de)
AU2097892A (en) Transdermal estradiol delivery system
AU8132787A (en) Penetration enhancers for transdermal delivery of systemic agents
AU7803587A (en) Transdermal therapeutic system, its use and production process
IE882080L (en) Transdermal therapeutic system
AU533491B2 (en) Bandage for administering drugs to the skin
ATE42901T1 (de) Haftendes arzneimittelpraeparat fuer perkutane absorption.
AU4877090A (en) Therapeutic system for the retarded and controlled transdermal or transmucous administration of active substances
ATE69720T1 (de) Transdermales system fuer timolol.
NZ220016A (en) Transdermal drug delivery system with drug reservoir(s), adhesive layer(s) and flexible backing layer
AU3893889A (en) A novel discontinuous adhesive surface
ATE164769T1 (de) Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen
EP0325613A4 (de) Eindringungserhöhende mittel zur transdermalen verabreichung systemischer mittel.
EP0138551A3 (de) System zur transdermalen Abgabe von Nitroglycerin
AU622775B2 (en) A plaster used as therapeutic system for the administration of active substances to the skin, which exhibits a graduated active substance release, process for the production of the plaster and the use thereof
GB2256367B (en) Transdermal administration of salts of medetomidine
IL106512A (en) Plaster for the transdermal application of steroid hormones and process for the preparation thereof
AU3772989A (en) Penetration enhancers for transdermal delivery of systemic agent
AU3740589A (en) Penetration enhancers for transdermal delivery of systemic agents
CA2010225A1 (en) Therapeutic System for the Retarded and Controlled Transdermal or Transmucous Administration of Active Substances (1)
AU2001230193A1 (en) Transdermal therapeutic system for the administration of zaleplon
AU8132487A (en) Penetration enhancers for transdermal delivery of systemic agents
ES8800609A1 (es) Procedimiento de obtencion de un parche para la administracion transdermica de agentes farmacologicamente activos.