ATE69720T1 - Transdermales system fuer timolol. - Google Patents

Transdermales system fuer timolol.

Info

Publication number
ATE69720T1
ATE69720T1 AT85115940T AT85115940T ATE69720T1 AT E69720 T1 ATE69720 T1 AT E69720T1 AT 85115940 T AT85115940 T AT 85115940T AT 85115940 T AT85115940 T AT 85115940T AT E69720 T1 ATE69720 T1 AT E69720T1
Authority
AT
Austria
Prior art keywords
timolol
drug
transdermal system
irritation
accomplished
Prior art date
Application number
AT85115940T
Other languages
English (en)
Inventor
Joseph V Bondi
Alice E Loper
Edward M Cohen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE69720T1 publication Critical patent/ATE69720T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
AT85115940T 1984-12-17 1985-12-13 Transdermales system fuer timolol. ATE69720T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/682,447 US4752478A (en) 1984-12-17 1984-12-17 Transdermal system for timolol
EP85115940A EP0186071B1 (de) 1984-12-17 1985-12-13 Transdermales System für Timolol

Publications (1)

Publication Number Publication Date
ATE69720T1 true ATE69720T1 (de) 1991-12-15

Family

ID=24739746

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85115940T ATE69720T1 (de) 1984-12-17 1985-12-13 Transdermales system fuer timolol.

Country Status (8)

Country Link
US (1) US4752478A (de)
EP (1) EP0186071B1 (de)
JP (1) JPH0684304B2 (de)
AT (1) ATE69720T1 (de)
CA (1) CA1261267A (de)
DE (1) DE3584766D1 (de)
DK (1) DK581685A (de)
ES (1) ES8702153A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797284A (en) * 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
US4954343A (en) * 1986-03-29 1990-09-04 Nitto Electric Industrial Co., Ltd. Dermal pharmaceutical preparations
US4938759A (en) * 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US4956181A (en) * 1987-05-08 1990-09-11 Eastman Kodak Nitrate therapy for angina pectoris
GB8804164D0 (en) * 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
JPH02149514A (ja) * 1988-04-06 1990-06-08 Nitto Denko Corp 医薬部材
FI82240C (fi) * 1988-10-20 1991-02-11 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt vaerdefullt s-timolol-hemihydrat.
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5484604A (en) * 1990-07-21 1996-01-16 Chatfield Pharmaceuticals Limited Cross-linked alginate transdermal medicine delivery devices
US5246706A (en) * 1991-07-19 1993-09-21 Cygnus Therapeutic Systems Device for administering bimakalim transdermally
DE69220484T2 (de) * 1992-07-08 1998-02-05 Leiras Oy, Turku Augenarzneimittel enthaltend Timolol Hemihydrat
DE4224325C1 (de) * 1992-07-23 1994-02-10 Sanol Arznei Schwarz Gmbh Wirkstoffpflaster für niedrigschmelzende und/oder flüchtige Wirkstoffe und Verfahren zu seiner Herstellung
JPH08503465A (ja) * 1992-11-09 1996-04-16 ファーメトリックス コーポレイション ケトロラックの経皮デリバリー
DE4400769C2 (de) * 1994-01-13 1996-07-18 Lohmann Therapie Syst Lts Verfahren und Vorrichtung zur Herstellung einer flächigen Darreichungsform mit einer Arzneimittelwirkstoffe enthaltenden Zubereitung
GB9711032D0 (en) * 1997-05-30 1997-07-23 Johnson Matthey Plc Compound as a stimulant for the central nervous system
EP1293210B1 (de) * 2001-05-23 2003-11-19 Pantarhei Bioscience B.V. Zubereitungen für die hormonale Kontrazeption
WO2002094280A1 (en) * 2001-05-23 2002-11-28 Pantarhei Bioscience B.V. Means and method for hormonal contraception
EP1389117A1 (de) * 2001-05-23 2004-02-18 Pantarhei Bioscience B.V. Mittel und verfahren zur hormonalen kontrazeption
EP2305230B1 (de) 2001-12-05 2015-11-04 Teva Women's Health, Inc. Orale Verhütungsmittel zum Verhindern einer Schwangerschaft
JP2007534622A (ja) * 2003-07-16 2007-11-29 デュラメド ファーマシューティカルズ インコーポレーティッド 連続的エストロゲン投与での避妊薬療法を利用するホルモン処置の方法
JP2008500340A (ja) * 2004-05-26 2008-01-10 ワイス 月経前不機嫌性障害の処置のための組成物および方法
US20070111975A1 (en) 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
TW200726473A (en) * 2005-06-28 2007-07-16 Wyeth Corp Compositions and methods for treatment of cycle-related symptoms
EP1965776A1 (de) * 2005-12-08 2008-09-10 Fertin Pharma Transdermales tabak-alkaloid-pflaster mit geringer biegefestigkeit
FR2950802B1 (fr) 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
DE102010002558A1 (de) 2009-11-20 2011-06-01 Symrise Ag Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe
EP2394703B1 (de) 2010-06-14 2015-12-23 Symrise AG Kühlmischungen mit verstärkter Kühlwirkung von 5-Methyl-2-(propan-2-yl)cyclohexyl-N-ethyloxamat
US9029415B2 (en) 2010-06-14 2015-05-12 Symrise Ag Cooling mixtures with an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate
ES2861268T3 (es) 2011-09-20 2021-10-06 Basf Se Moduladores de bajo peso molecular del receptor de mentol frío TRPM8 y su uso
CN108697655B (zh) 2015-12-30 2021-12-10 考里安公司 用于长期透皮施药的系统和方法
AU2017281789B2 (en) 2016-06-23 2023-04-13 Corium, LLC. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
SG11201900712SA (en) * 2016-07-27 2019-02-27 Corium Int Inc Memantine transdermal delivery systems
JP7231617B2 (ja) 2017-08-31 2023-03-01 ビーエーエスエフ ソシエタス・ヨーロピア 生理学的冷涼活性成分の使用、及びそのような活性成分を含む組成物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4060084A (en) * 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
JPS56133381A (en) * 1980-03-25 1981-10-19 Nippon Kayaku Co Ltd Pressure-sensitive adhesive tape or sheet containing nitroglycerin
JPS57116011A (en) * 1981-01-08 1982-07-19 Nitto Electric Ind Co Ltd Pharmaceutical preparation
US4428883A (en) * 1981-03-06 1984-01-31 The University Of Kentucky Research Foundation Novel method of administering β-blockers and novel dosage forms containing same
US4560553A (en) * 1981-07-07 1985-12-24 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
US4440777A (en) * 1981-07-07 1984-04-03 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
US4559222A (en) * 1983-05-04 1985-12-17 Alza Corporation Matrix composition for transdermal therapeutic system
US4474752A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474753A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
DE3319469A1 (de) * 1983-05-28 1984-11-29 Akzo Gmbh, 5600 Wuppertal System zur transdermalen applikation von pharmakotherapeutisch wirksamen substanzen
EP0184910B1 (de) * 1984-11-15 1992-09-30 Hercon Laboratories Corporation Vorrichtung zur kontrollierten Abgabe von Arzneimittelwirkstoffen

Also Published As

Publication number Publication date
JPH0684304B2 (ja) 1994-10-26
DK581685A (da) 1986-06-18
EP0186071A3 (en) 1988-09-14
DK581685D0 (da) 1985-12-16
ES8702153A1 (es) 1987-01-01
EP0186071B1 (de) 1991-11-27
EP0186071A2 (de) 1986-07-02
CA1261267A (en) 1989-09-26
DE3584766D1 (de) 1992-01-09
ES550011A0 (es) 1987-01-01
US4752478A (en) 1988-06-21
JPS61145113A (ja) 1986-07-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee