ZA862510B - Pharmaceutical combination for increasing bone mass - Google Patents
Pharmaceutical combination for increasing bone massInfo
- Publication number
- ZA862510B ZA862510B ZA862510A ZA862510A ZA862510B ZA 862510 B ZA862510 B ZA 862510B ZA 862510 A ZA862510 A ZA 862510A ZA 862510 A ZA862510 A ZA 862510A ZA 862510 B ZA862510 B ZA 862510B
- Authority
- ZA
- South Africa
- Prior art keywords
- bone mass
- increasing bone
- pharmaceutical combination
- afflicted
- human
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 102000003982 Parathyroid hormone Human genes 0.000 abstract 1
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- -1 Vitamin D compound Chemical class 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 229940069978 calcium supplement Drugs 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000199 parathyroid hormone Substances 0.000 abstract 1
- 229960001319 parathyroid hormone Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72001885A | 1985-04-04 | 1985-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA862510B true ZA862510B (en) | 1986-11-26 |
Family
ID=24892318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA862510A ZA862510B (en) | 1985-04-04 | 1986-04-04 | Pharmaceutical combination for increasing bone mass |
Country Status (12)
Country | Link |
---|---|
US (1) | US4698328A (ja) |
EP (1) | EP0197514B1 (ja) |
JP (2) | JPH0772138B2 (ja) |
AT (1) | ATE79271T1 (ja) |
AU (1) | AU599905B2 (ja) |
CA (1) | CA1288695C (ja) |
DE (1) | DE3686343T2 (ja) |
DK (1) | DK172816B1 (ja) |
IE (1) | IE59620B1 (ja) |
IL (1) | IL78342A (ja) |
PH (1) | PH23720A (ja) |
ZA (1) | ZA862510B (ja) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4833125A (en) * | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
DE3725319A1 (de) * | 1987-07-30 | 1989-02-09 | Biotechnolog Forschung Gmbh | Pth-modifikationen und therapeutische zusammensetzungen, die sie enthalten und daraus bestehen |
EP0318184A1 (en) * | 1987-11-12 | 1989-05-31 | Schering Corporation | Acceleration of bone formation with GM-CSF |
JPH07110809B2 (ja) * | 1987-11-18 | 1995-11-29 | 帝人株式会社 | 更年期障害の治療薬 |
IL89392A (en) * | 1988-03-23 | 1993-02-21 | Teva Pharmaceutical Ind Ltd Je | Compositions for the treatment of osteoporosis in humans comprising 24, 25-dihydroxy-vitamin d3 |
US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
US4942036A (en) * | 1988-08-25 | 1990-07-17 | Blair Geho W | Therapy by vesicle delivery to the hydroxyapatite of bone |
DE4026146A1 (de) * | 1990-08-17 | 1992-02-20 | Biotechnolog Forschung Gmbh | Mittregionale pth fragmente in kombination mit 1,25(oh)(pfeil abwaerts)2(pfeil abwaerts)(pfeil hoch)d(pfeil hoch)(pfeil abwaerts)3(pfeil abwaerts) bewirken einen anabolen effekt (calciumeinbau) auf den knochen |
CA2096933C (en) * | 1990-12-13 | 2003-05-13 | Bruce E. Kemp | Compounds and compositions which inhibit bone resorption |
US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
JPH07502507A (ja) * | 1991-12-17 | 1995-03-16 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | ビスホスホネート類及び副甲状腺ホルモンを用いた骨粗鬆症の治療方法 |
US5382658A (en) * | 1992-04-03 | 1995-01-17 | Allelix Biopharmaceuticals Inc. | Stability-enhanced variants of parathyroid hormone |
CA2098639A1 (en) * | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
KR100291620B1 (ko) * | 1992-09-29 | 2001-10-24 | 추후제출 | 부갑상선호르몬의활성단편의폐를통한전달방법 |
US7448375B2 (en) | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
TW303299B (ja) * | 1993-07-22 | 1997-04-21 | Lilly Co Eli | |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US5496801A (en) * | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
ES2218543T3 (es) * | 1994-03-07 | 2004-11-16 | Nektar Therapeutics | Procedimiento y preparacion para la administracion de insulina por via pulmonar. |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6376479B1 (en) | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US5780014A (en) * | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
KR20000071039A (ko) | 1997-02-13 | 2000-11-25 | 비숍 찰스 더블유. | 비타민 d 화합물의 표적화된 치료학적 전달 |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
EP0891779A1 (de) * | 1997-06-19 | 1999-01-20 | Roche Diagnostics GmbH | Pharmazeutische Kombinationspräparate enthaltend Parathyroidhormon und Calcium- und/oder Phosphatverbindungen |
US6770623B1 (en) * | 1997-12-09 | 2004-08-03 | Eli Lilly And Company | Stabilized teriparatide solutions |
DZ2873A1 (fr) * | 1998-08-19 | 2003-12-15 | Lilly Co Eli | Procédé pour augmenter la dureté et la rigidité osseuse. |
US20040033950A1 (en) * | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
US6777388B1 (en) * | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
WO2000023594A1 (en) * | 1998-10-22 | 2000-04-27 | The General Hospital Corporation | BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP) |
AU1918300A (en) * | 1998-11-25 | 2000-06-13 | General Hospital Corporation, The | Amino-terminal modified parathyroid hormone (pth) analogs |
US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
JP2002533115A (ja) * | 1998-12-31 | 2002-10-08 | ザ ジェネラル ホスピタル コーポレーション | Pth機能的ドメイン結合体ペプチド、それらの誘導体、および新規係留リガンド−レセプター分子 |
US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
CA2383574A1 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Method for reducing the risk of cancer |
US7022815B1 (en) | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
EP1222208B1 (en) | 1999-09-29 | 2008-10-29 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
EP1301479A2 (en) * | 2000-07-18 | 2003-04-16 | Bone Care International, Inc. | STABILIZED 1$g(a)-HYDROXY VITAMIN D |
US7226442B2 (en) * | 2000-10-10 | 2007-06-05 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
CA2454275C (en) * | 2001-07-23 | 2012-10-23 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
US20030119771A1 (en) * | 2001-08-22 | 2003-06-26 | Rompaey Luc Van | Modulators of bone homeostasis identified in a high-throughput screen |
GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
AU2003278766A1 (en) * | 2002-09-04 | 2004-03-29 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
WO2004067021A1 (en) * | 2003-01-24 | 2004-08-12 | Gardella Thomas J | Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges |
EP1610813A4 (en) * | 2003-03-19 | 2009-07-01 | Gen Hospital Corp | PARATHYROIDAL HORMONES CONFORMALLY CONFORMALLY CONSTRAINED WITH PROPELLER STABILIZERS $ G (A) |
PT2266584E (pt) * | 2003-05-07 | 2012-12-19 | Osteologix As | Composição com estrôncio e vitamina d para a profilaxia/tratamento de patologias da cartilagem e/ou do osso |
EP1653985A4 (en) | 2003-07-17 | 2009-08-05 | Gen Hospital Corp | CONSTRAINTS CONTAINING CONTAINING HORMONE PARATHYROID (PTH) ANALOGUES |
JP2007501241A (ja) * | 2003-08-06 | 2007-01-25 | ローディア インコーポレイティド | 骨成長を促進する方法 |
KR20060058133A (ko) * | 2003-09-19 | 2006-05-29 | 화이자 프로덕츠 인코포레이티드 | 2-알킬리덴-19-노르-비타민 d 유도체 및 부갑상선호르몬의 조합을 포함하는 약학 조성물 및 방법 |
JP4815752B2 (ja) * | 2004-04-01 | 2011-11-16 | 味の素株式会社 | アミノ酸含有飲食品 |
EP1744683B1 (en) | 2004-05-13 | 2016-03-16 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
EP1843783B1 (en) * | 2005-01-25 | 2012-05-30 | MicroCHIPS, Inc. | Control of drug release by transient modification of local microenvironments |
US20080076975A1 (en) * | 2005-01-25 | 2008-03-27 | Microchips, Inc. | Method and implantable device with reservoir array for pre-clinical in vivo testing |
EP1945245A2 (en) * | 2005-11-10 | 2008-07-23 | The Board of Control of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
JP2009545320A (ja) | 2006-08-04 | 2009-12-24 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン(pth)のポリペプチド誘導体 |
AU2008282805B2 (en) | 2007-08-01 | 2014-05-01 | Chugai Pharmaceutical Co., Ltd. | Screening methods using G-protein coupled receptors and related compositions |
BR112012013725A2 (pt) | 2009-12-07 | 2017-01-10 | Univ Michigan Tech | paratormônio de urso preto e métodos de usar o paratormônio de uso preto. |
RU2604809C2 (ru) | 2010-05-13 | 2016-12-10 | Дзе Дженерал Хоспитал Корпорейшн | Аналоги паратиреоидного гормона и их применение |
WO2012111852A1 (ja) * | 2011-02-17 | 2012-08-23 | 帝人ファーマ株式会社 | 椎体骨折治療剤及びその評価方法 |
US9418415B2 (en) * | 2014-02-05 | 2016-08-16 | Shimadzu Corporation | Trabecular bone analyzer |
CN110236710A (zh) * | 2018-03-09 | 2019-09-17 | 中日友好医院 | 一种促进植骨材料在牙种植上颌窦外提升术后成骨的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3956260A (en) * | 1967-11-09 | 1976-05-11 | Ciba-Geigy Corporation | Hypocalcaemic peptides and processes for their manufacture |
US4241051A (en) * | 1977-11-04 | 1980-12-23 | Christie Robert B | Calcitonin |
JPS55139320A (en) * | 1979-04-16 | 1980-10-31 | Teijin Ltd | Bone metabolism regulator |
DE3243358A1 (de) * | 1982-11-24 | 1984-05-24 | Rolf Dieter Prof.Dr. 3004 Isernhagen Hesch | Synthetisches humanes (1-38) parathormon-fragment, verfahren zu seiner herstellung und die verwendung zur behandlung der osteoporose |
-
1986
- 1986-03-31 IL IL78342A patent/IL78342A/xx unknown
- 1986-04-03 AU AU55616/86A patent/AU599905B2/en not_active Ceased
- 1986-04-03 AT AT86104562T patent/ATE79271T1/de not_active IP Right Cessation
- 1986-04-03 EP EP86104562A patent/EP0197514B1/en not_active Expired - Lifetime
- 1986-04-03 DE DE8686104562T patent/DE3686343T2/de not_active Expired - Fee Related
- 1986-04-04 ZA ZA862510A patent/ZA862510B/xx unknown
- 1986-04-04 DK DK198601556A patent/DK172816B1/da not_active IP Right Cessation
- 1986-04-04 PH PH33623A patent/PH23720A/en unknown
- 1986-04-04 JP JP61078048A patent/JPH0772138B2/ja not_active Expired - Fee Related
- 1986-04-04 CA CA000505901A patent/CA1288695C/en not_active Expired - Lifetime
- 1986-04-04 IE IE89186A patent/IE59620B1/en not_active IP Right Cessation
- 1986-12-05 US US06/939,308 patent/US4698328A/en not_active Expired - Lifetime
-
1994
- 1994-12-05 JP JP6300817A patent/JP2531505B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK155686D0 (da) | 1986-04-04 |
AU5561686A (en) | 1986-10-09 |
JPS6233A (ja) | 1987-01-06 |
EP0197514A1 (en) | 1986-10-15 |
CA1288695C (en) | 1991-09-10 |
US4698328A (en) | 1987-10-06 |
DE3686343T2 (de) | 1993-01-28 |
DK155686A (da) | 1986-10-05 |
JPH07179358A (ja) | 1995-07-18 |
ATE79271T1 (de) | 1992-08-15 |
IE59620B1 (en) | 1994-03-09 |
IE860891L (en) | 1986-10-04 |
EP0197514B1 (en) | 1992-08-12 |
AU599905B2 (en) | 1990-08-02 |
JPH0772138B2 (ja) | 1995-08-02 |
DE3686343D1 (de) | 1992-09-17 |
JP2531505B2 (ja) | 1996-09-04 |
DK172816B1 (da) | 1999-08-02 |
IL78342A (en) | 1991-06-10 |
PH23720A (en) | 1989-11-03 |
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