ZA858942B - Substituted imidazole derivatives and their preparation and use - Google Patents

Substituted imidazole derivatives and their preparation and use

Info

Publication number
ZA858942B
ZA858942B ZA858942A ZA858942A ZA858942B ZA 858942 B ZA858942 B ZA 858942B ZA 858942 A ZA858942 A ZA 858942A ZA 858942 A ZA858942 A ZA 858942A ZA 858942 B ZA858942 B ZA 858942B
Authority
ZA
South Africa
Prior art keywords
och3
preparation
ch2ch3
hal
imidazole derivatives
Prior art date
Application number
ZA858942A
Other languages
English (en)
Inventor
Arto Johannes Karjalainen
Raimo Einari Virtanen
Arja Leena Karjalainen
Kauko Oiva Antero Kurkela
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Oy filed Critical Farmos Oy
Publication of ZA858942B publication Critical patent/ZA858942B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
ZA858942A 1984-11-23 1985-11-21 Substituted imidazole derivatives and their preparation and use ZA858942B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use

Publications (1)

Publication Number Publication Date
ZA858942B true ZA858942B (en) 1986-08-27

Family

ID=10570140

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA858942A ZA858942B (en) 1984-11-23 1985-11-21 Substituted imidazole derivatives and their preparation and use

Country Status (26)

Country Link
US (1) US4689339A (el)
EP (2) EP0183492B1 (el)
JP (1) JPH064597B2 (el)
KR (1) KR930004673B1 (el)
AT (2) ATE47997T1 (el)
AU (2) AU586839B2 (el)
BG (1) BG60762B2 (el)
CA (1) CA1268770C (el)
DD (1) DD258230A1 (el)
DE (2) DE3587045T2 (el)
DK (2) DK164903C (el)
ES (2) ES8704462A1 (el)
FI (1) FI80264C (el)
GB (1) GB2167408B (el)
GR (1) GR852817B (el)
HK (1) HK3592A (el)
HU (1) HU195189B (el)
IE (1) IE58165B1 (el)
IL (1) IL77111A (el)
NO (1) NO166585C (el)
NZ (1) NZ214258A (el)
PH (1) PH22016A (el)
PT (1) PT81542B (el)
SG (1) SG106891G (el)
SU (1) SU1424736A3 (el)
ZA (1) ZA858942B (el)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252162A4 (en) * 1986-01-28 1988-07-29 Mitsui Petrochemical Ind METHOD FOR PRODUCING 2-UNSUBSTITUTED IMIDAZOLES.
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
AU669866B2 (en) * 1991-11-05 1996-06-27 Smithkline Beecham Corporation Endothelin receptor antagonists
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
AU8031698A (en) * 1997-06-05 1998-12-21 Venantius Limited Indane compounds and their pharmaceutical use
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
WO2000042023A1 (en) * 1999-01-18 2000-07-20 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6388090B2 (en) * 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
JP2003532712A (ja) 2000-05-08 2003-11-05 オリオン コーポレーション α２アドレナリン作用活性を有する新規な多環式インダニルイミダゾール
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
AU2003216760A1 (en) 2002-04-03 2003-10-13 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) * 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
US20070049631A1 (en) * 2003-11-04 2007-03-01 Akzo Nobel N.V. Ectoparasiticidal formulations of spinosyms and azole pesticides
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
TR201815853T4 (tr) 2005-10-12 2018-11-21 Besins Healthcare Sarl Hipogonadizmin tedavisinde kullanıma yönelik geliştirilmiş testosteron jeli.
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
ATE459251T1 (de) * 2006-08-08 2010-03-15 Intervet Int Bv Zusammensetzung für verstärkte antiparasitische wirksamkeit
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
CN105873587B (zh) 2013-11-05 2020-07-21 3M创新有限公司 基于芝麻油的注射配制品
AR104882A1 (es) 2015-06-05 2017-08-23 Orion Corp DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
ES2861502T3 (es) * 2015-11-05 2021-10-06 Univ Louisville Res Found Inc Anestesia y analgesia locales y regionales
CN109415355A (zh) 2016-06-29 2019-03-01 奥赖恩公司 苯并二噁烷衍生物及其药物用途
US20220072107A1 (en) 2018-12-21 2022-03-10 Societe Des Produits Nestle S.A. Nutritional composition for inducing a feeling of satiety, a better sleep and/or limiting nocturnal awaking in infants or young children
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
IL62122A0 (en) * 1980-03-04 1981-03-31 Erba Farmitalia N-imidazolyl derivatives of 1-chroman,their preparation and pharmaceutical compositions containing them
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
HU195189B (en) 1988-04-28
DK58292A (da) 1992-05-04
IL77111A0 (en) 1986-04-29
DK540485A (da) 1986-05-24
EP0183492B1 (en) 1989-11-15
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
US4689339A (en) 1987-08-25
NO166585B (no) 1991-05-06
ES557268A0 (es) 1987-12-16
IE58165B1 (en) 1993-07-28
ES8704462A1 (es) 1987-04-01
CA1266669A1 (en) 1990-03-13
GB2167408B (en) 1988-05-25
AU5008385A (en) 1986-05-29
EP0310745A3 (en) 1989-10-11
GB8429578D0 (en) 1985-01-03
GR852817B (el) 1986-03-21
IE852929L (en) 1986-05-23
EP0183492A1 (en) 1986-06-04
DK540485D0 (da) 1985-11-22
ES549178A0 (es) 1987-04-01
FI854335A (fi) 1986-05-24
HUT38913A (en) 1986-07-28
CA1268770C (en) 1990-05-08
KR930004673B1 (ko) 1993-06-03
IL77111A (en) 1989-09-28
BG60762B2 (bg) 1996-02-29
NO166585C (no) 1991-08-21
AU586839B2 (en) 1989-07-27
ATE85050T1 (de) 1993-02-15
NZ214258A (en) 1989-02-24
FI80264C (fi) 1990-05-10
ATE47997T1 (de) 1989-12-15
KR860004028A (ko) 1986-06-16
PT81542B (pt) 1988-03-03
DE3587045D1 (de) 1993-03-11
EP0310745A2 (en) 1989-04-12
FI80264B (fi) 1990-01-31
EP0310745B1 (en) 1993-01-27
AU3332989A (en) 1989-08-10
GB2167408A (en) 1986-05-29
JPH064597B2 (ja) 1994-01-19
DE3574252D1 (en) 1989-12-21
SU1424736A3 (ru) 1988-09-15
DK164903C (da) 1993-01-25
FI854335A0 (fi) 1985-11-05
HK3592A (en) 1992-01-17
JPS61143366A (ja) 1986-07-01
DK58292D0 (da) 1992-05-04
PT81542A (en) 1985-12-01
DD258230A1 (de) 1988-07-13
DE3587045T2 (de) 1993-06-03
ES8801248A1 (es) 1987-12-16
SG106891G (en) 1992-02-14
DK164903B (da) 1992-09-07

Similar Documents

Publication Publication Date Title
GB2167408B (en) Substituted imidazole derivatives and their preparation and use
IL74031A0 (en) Cyanoguanidinophenyldihydropyridazinone derivatives,their preparation and pharmaceutical compositions containing them
FI871655A (fi) Foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
PH24176A (en) New bicyclic compounds,process for preparation thereof and pharmaceutical composition comprising the same
HUT52065A (en) Process for producing substituted imidazol derivatives and pharmaceutical compositions containing them
DE3362301D1 (en) Thieno-thiazole derivatives, process for their preparation and medicaments containing them
DE3160719D1 (en) Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them
ZA838139B (en) Semicarbazides,process for preparing these,and pharmaceutical compositions thereof