ZA856414B - Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical use - Google Patents

Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical use

Info

Publication number
ZA856414B
ZA856414B ZA856414A ZA856414A ZA856414B ZA 856414 B ZA856414 B ZA 856414B ZA 856414 A ZA856414 A ZA 856414A ZA 856414 A ZA856414 A ZA 856414A ZA 856414 B ZA856414 B ZA 856414B
Authority
ZA
South Africa
Prior art keywords
butyrolactams
preparation
pharmacologically active
medical use
active compositions
Prior art date
Application number
ZA856414A
Other languages
English (en)
Inventor
Yan-Rong Chem
Ming-He Yang
Liang Huang
Geng-Tao Liu
Ulrich Benz
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA856414B publication Critical patent/ZA856414B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrrole Compounds (AREA)
  • Joining Of Building Structures In Genera (AREA)
  • Package Frames And Binding Bands (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
ZA856414A 1984-08-24 1985-08-23 Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical use ZA856414B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843431257 DE3431257A1 (de) 1984-08-24 1984-08-24 Neue (delta)-butyrolactame, pharmakologisch aktive zusammensetzungen derselben, verfahren zu ihrer herstellung und ihre medizinische verwendung

Publications (1)

Publication Number Publication Date
ZA856414B true ZA856414B (en) 1986-04-30

Family

ID=6243847

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA856414A ZA856414B (en) 1984-08-24 1985-08-23 Novel alpha-butyrolactams,pharmacologically active compositions thereof,process for the preparation thereof and their medical use

Country Status (16)

Country Link
US (1) US4879390A (ja)
EP (1) EP0172514B1 (ja)
JP (1) JPH0660159B2 (ja)
KR (1) KR860001787A (ja)
AT (1) ATE46504T1 (ja)
AU (1) AU571729B2 (ja)
CA (1) CA1262250A (ja)
DE (2) DE3431257A1 (ja)
DK (1) DK385285A (ja)
ES (2) ES8609241A1 (ja)
FI (1) FI853228L (ja)
GR (1) GR852050B (ja)
HU (1) HU195774B (ja)
IL (1) IL76157A (ja)
PT (1) PT81005B (ja)
ZA (1) ZA856414B (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU579029B2 (en) * 1985-10-18 1988-11-10 Bayer Aktiengesellschaft Process for the preparation of ` -butyrolactams
DE3616989A1 (de) * 1986-05-21 1987-11-26 Bayer Ag Enantiomerenreine 4,5-disubstituierte (gamma)-butyrolactame, verfahren zu ihrer herstellung und ihre verwendung
DE3927367A1 (de) * 1989-08-19 1991-02-21 Bayer Ag Verfahren zur herstellung von dehydrocycloclausenamid und dessen derivate in der racemischen form und als optisch aktive (+) oder (-)-enantiomere
DE3927370A1 (de) * 1989-08-19 1991-02-21 Bayer Ag Verfahren zur herstellung von clausenamid und neoclausenamid und deren derivate
JP4585073B2 (ja) * 2000-02-15 2010-11-24 丸善製薬株式会社 抗男性ホルモン剤、養毛化粧料、前立腺肥大抑制剤、外用剤及び飲食品
US6787564B2 (en) * 2002-03-26 2004-09-07 Institute Of Materia Medica, Chinese Academy Of Medical Sciences Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use
EP1348696B1 (en) * 2002-03-26 2012-02-01 Institute Of Materia Medica, Chinese Academy Of Medical Sciences Use of optically active clausenamides for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same
CN1295215C (zh) * 2002-12-31 2007-01-17 中国医学科学院药物研究所 黄皮酰胺的光学活性衍生物、其制法和其药物组合物与用途
WO2016015333A1 (en) * 2014-08-01 2016-02-04 F.Hoffmann-La Roche Ag 2-oxa-5-azabicyclo [2.2.1] heptan-3-yl derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI325174A (ja) * 1973-11-19 1975-05-20 Sandoz Ag

Also Published As

Publication number Publication date
FI853228A0 (fi) 1985-08-22
FI853228L (fi) 1986-02-25
HUT38904A (en) 1986-07-28
EP0172514A1 (en) 1986-02-26
AU4657185A (en) 1986-02-27
ES554061A0 (es) 1987-04-01
IL76157A (en) 1988-08-31
JPS62181250A (ja) 1987-08-08
IL76157A0 (en) 1985-12-31
DK385285A (da) 1986-02-25
HU195774B (en) 1988-07-28
EP0172514B1 (en) 1989-09-20
KR860001787A (ko) 1986-03-22
ES8609241A1 (es) 1986-07-16
ES546381A0 (es) 1986-07-16
DE3431257A1 (de) 1986-03-06
PT81005B (en) 1987-06-26
JPH0660159B2 (ja) 1994-08-10
DK385285D0 (da) 1985-08-23
ES8704457A1 (es) 1987-04-01
CA1262250A (en) 1989-10-10
DE3573113D1 (en) 1989-10-26
GR852050B (ja) 1985-12-20
ATE46504T1 (de) 1989-10-15
US4879390A (en) 1989-11-07
PT81005A (en) 1985-09-01
AU571729B2 (en) 1988-04-21

Similar Documents

Publication Publication Date Title
UA34428C2 (uk) Заміщені фенілімідазолідини, спосіб їх одержання, фармацевтична композиція, проміжні сполуки
TW352384B (en) Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
ES8801785A1 (es) Un procedimiento para la preparacion de nuevas azetidinonas sustituidas.
EP0279149A3 (en) Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same
DE3571982D1 (en) Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds
ES8707724A1 (es) Un procedimiento para preparar laudanos
ES8801243A1 (es) Procedimiento para la obtencion de medicamentos que contienen 1-heteroaril-4--aril-pirazolin-5-onas.
DE3573113D1 (en) Novel delta-butyrolactams, pharmacologically active compositions thereof, processes for the preparation thereof and their medical use
IL85945A0 (en) Pharmaceutical compositions containing 2'-fluoronucleosides and derivatives thereof,certain such novel compounds and their preparation
JO1406B1 (en) Chemical compounds
ES8107192A1 (es) Un procedimiento para la preparacion de un compuesto sele- ccionado entre el grupo formado por una imidazolilurea
ES8500226A1 (es) Un procedimiento de preparacion de imino-2-pirrolidinas.
ES8102147A1 (es) Procedimiento para la obtencion de derivados de sisomicina
ZA837332B (en) Novel galenic form of sulpiride,process for its preparation and medicament comprising said novel form
ES8308833A1 (es) "un metodo para la preparacion de 3-fenil-1-indanaminas".
UA37217C2 (uk) Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки
IL70665A0 (en) Novel condensed pyrrole derivatives,process for their preparation and pharmaceutical compositions containing the same
PT77986A (en) Process to prepare pharmaceutical compositions including 3,4-dihydroxiphenylethyl amine derivatives
DE2860709D1 (en) 1-substituted aminoindolines, process for their production and pharmaceutical compositions containing them
ES8605261A1 (es) Un procedimiento para la preparacion de 1,4-aminoalquilamino-9-h-tioxaten-9-onas.
ES8704148A1 (es) Un procedimiento para preparar derivados de antraciclina
EP0049842A3 (en) Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates
ES8609301A1 (es) Procedimiento para la obtencion de 3-metil-7-fluor-5-nitro- benzotiofeno
MY103900A (en) 6-substituted 2'', 3''-dideoxynucleosides and pharmaceutical compositions
ES8302627A1 (es) Procedimiento de preparacion de un nuevo derivado de 5-hidroxi-l-triptofano.