ES8704457A1 - Un procedimiento para la preparacion de una composicion farmaceutica que contiene como ingrediente activo una nueva a -butirolactma - Google Patents
Un procedimiento para la preparacion de una composicion farmaceutica que contiene como ingrediente activo una nueva a -butirolactmaInfo
- Publication number
- ES8704457A1 ES8704457A1 ES554061A ES554061A ES8704457A1 ES 8704457 A1 ES8704457 A1 ES 8704457A1 ES 554061 A ES554061 A ES 554061A ES 554061 A ES554061 A ES 554061A ES 8704457 A1 ES8704457 A1 ES 8704457A1
- Authority
- ES
- Spain
- Prior art keywords
- butyrolactams
- processes
- preparation
- pharmacologically active
- medical use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Package Frames And Binding Bands (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Joining Of Building Structures In Genera (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
PROCEDIMIENTO PARA AISLAR UNA COMPOSICION FARMACEUTICA QUE CONTIENE UNA S-BUTIROLACTAMA COMO INGREDIENTE ACTIVO. COMPRENDE: A) HERVIR LAS HOJAS DE CLAUSENA LANSIUM CON AGUA; B) AGREGAR ACIDO CLORHIDRICO DILUIDO AL EXTRACTO DE A), FORMANDOSE UNA SOLUCION Y UN SOBRENADANTE; C) HACER PASAR AL SOBRENADANTE DE LA SOLUCION A TRAVES DE UNA RESINA INTERCAMBIADORA DE IONES CATIONICOS; D) TRATAR A LA RESINA CON AMONIACO DILUIDO; E) EXTRAER LA RESINA DE D) CON DIETIL ETER; F) CROMATOGRAFIAR EL EXTRACTO CONCENTRADO SOBRE SIO2 O AL2O3 CON CLOROFORMO O MEZCLA DE CLOROFORMO/METANOL; Y G) RECOGER Y CONCENTRAR AL ELUATO DE F) CON VALORES ENTRE 0,80 Y 0,20 DE GEL DE SILICE Y DE ELUYENTE. SE UTILIZAN PARA EL TRATAMIENTO DE LA HIPOSIA Y LA AMNESIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843431257 DE3431257A1 (de) | 1984-08-24 | 1984-08-24 | Neue (delta)-butyrolactame, pharmakologisch aktive zusammensetzungen derselben, verfahren zu ihrer herstellung und ihre medizinische verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES554061A0 ES554061A0 (es) | 1987-04-01 |
ES8704457A1 true ES8704457A1 (es) | 1987-04-01 |
Family
ID=6243847
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546381A Expired ES8609241A1 (es) | 1984-08-24 | 1985-08-23 | Nuevas butirolactamas, composiciones farmacologicamente activas de las mismas, procedimientos para su obtencion y su empleo en medicina. |
ES554061A Expired ES8704457A1 (es) | 1984-08-24 | 1986-04-16 | Un procedimiento para la preparacion de una composicion farmaceutica que contiene como ingrediente activo una nueva a -butirolactma |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546381A Expired ES8609241A1 (es) | 1984-08-24 | 1985-08-23 | Nuevas butirolactamas, composiciones farmacologicamente activas de las mismas, procedimientos para su obtencion y su empleo en medicina. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4879390A (es) |
EP (1) | EP0172514B1 (es) |
JP (1) | JPH0660159B2 (es) |
KR (1) | KR860001787A (es) |
AT (1) | ATE46504T1 (es) |
AU (1) | AU571729B2 (es) |
CA (1) | CA1262250A (es) |
DE (2) | DE3431257A1 (es) |
DK (1) | DK385285A (es) |
ES (2) | ES8609241A1 (es) |
FI (1) | FI853228L (es) |
GR (1) | GR852050B (es) |
HU (1) | HU195774B (es) |
IL (1) | IL76157A (es) |
PT (1) | PT81005B (es) |
ZA (1) | ZA856414B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU579029B2 (en) * | 1985-10-18 | 1988-11-10 | Bayer Aktiengesellschaft | Process for the preparation of ` -butyrolactams |
DE3616989A1 (de) * | 1986-05-21 | 1987-11-26 | Bayer Ag | Enantiomerenreine 4,5-disubstituierte (gamma)-butyrolactame, verfahren zu ihrer herstellung und ihre verwendung |
DE3927367A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Verfahren zur herstellung von dehydrocycloclausenamid und dessen derivate in der racemischen form und als optisch aktive (+) oder (-)-enantiomere |
DE3927370A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Verfahren zur herstellung von clausenamid und neoclausenamid und deren derivate |
JP4585073B2 (ja) * | 2000-02-15 | 2010-11-24 | 丸善製薬株式会社 | 抗男性ホルモン剤、養毛化粧料、前立腺肥大抑制剤、外用剤及び飲食品 |
US6787564B2 (en) * | 2002-03-26 | 2004-09-07 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use |
EP1348696B1 (en) * | 2002-03-26 | 2012-02-01 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Use of optically active clausenamides for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same |
CN1295215C (zh) * | 2002-12-31 | 2007-01-17 | 中国医学科学院药物研究所 | 黄皮酰胺的光学活性衍生物、其制法和其药物组合物与用途 |
WO2016015333A1 (en) * | 2014-08-01 | 2016-02-04 | F.Hoffmann-La Roche Ag | 2-oxa-5-azabicyclo [2.2.1] heptan-3-yl derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI325174A (es) * | 1973-11-19 | 1975-05-20 | Sandoz Ag |
-
1984
- 1984-08-24 DE DE19843431257 patent/DE3431257A1/de not_active Withdrawn
-
1985
- 1985-08-12 AT AT85110087T patent/ATE46504T1/de not_active IP Right Cessation
- 1985-08-12 EP EP85110087A patent/EP0172514B1/en not_active Expired
- 1985-08-12 DE DE8585110087T patent/DE3573113D1/de not_active Expired
- 1985-08-21 IL IL76157A patent/IL76157A/xx unknown
- 1985-08-22 JP JP60183161A patent/JPH0660159B2/ja not_active Expired - Lifetime
- 1985-08-22 CA CA000489253A patent/CA1262250A/en not_active Expired
- 1985-08-22 PT PT81005A patent/PT81005B/pt unknown
- 1985-08-22 AU AU46571/85A patent/AU571729B2/en not_active Ceased
- 1985-08-22 FI FI853228A patent/FI853228L/fi not_active Application Discontinuation
- 1985-08-23 GR GR852050A patent/GR852050B/el unknown
- 1985-08-23 HU HU853219A patent/HU195774B/hu not_active IP Right Cessation
- 1985-08-23 ES ES546381A patent/ES8609241A1/es not_active Expired
- 1985-08-23 ZA ZA856414A patent/ZA856414B/xx unknown
- 1985-08-23 KR KR1019850006078A patent/KR860001787A/ko not_active IP Right Cessation
- 1985-08-23 DK DK385285A patent/DK385285A/da not_active Application Discontinuation
-
1986
- 1986-04-16 ES ES554061A patent/ES8704457A1/es not_active Expired
-
1988
- 1988-04-27 US US07/186,540 patent/US4879390A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA1262250A (en) | 1989-10-10 |
FI853228L (fi) | 1986-02-25 |
ES8609241A1 (es) | 1986-07-16 |
US4879390A (en) | 1989-11-07 |
DK385285A (da) | 1986-02-25 |
ZA856414B (en) | 1986-04-30 |
EP0172514B1 (en) | 1989-09-20 |
DE3431257A1 (de) | 1986-03-06 |
IL76157A (en) | 1988-08-31 |
JPH0660159B2 (ja) | 1994-08-10 |
ATE46504T1 (de) | 1989-10-15 |
HU195774B (en) | 1988-07-28 |
PT81005A (en) | 1985-09-01 |
GR852050B (es) | 1985-12-20 |
DK385285D0 (da) | 1985-08-23 |
IL76157A0 (en) | 1985-12-31 |
EP0172514A1 (en) | 1986-02-26 |
JPS62181250A (ja) | 1987-08-08 |
FI853228A0 (fi) | 1985-08-22 |
PT81005B (en) | 1987-06-26 |
AU571729B2 (en) | 1988-04-21 |
ES546381A0 (es) | 1986-07-16 |
DE3573113D1 (en) | 1989-10-26 |
HUT38904A (en) | 1986-07-28 |
ES554061A0 (es) | 1987-04-01 |
KR860001787A (ko) | 1986-03-22 |
AU4657185A (en) | 1986-02-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL76454A0 (en) | Diarylacetylenes,their preparation and pharmaceutical compositions containing them | |
ES8502687A1 (es) | Procedimiento para preparar derivados de 4-oxo-1,4-dihidroquinoleina. | |
IL112622A (en) | Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them | |
ES8500931A1 (es) | Procedimiento para la obtencion de acidos quinoloncarboxilicos | |
ES8609241A1 (es) | Nuevas butirolactamas, composiciones farmacologicamente activas de las mismas, procedimientos para su obtencion y su empleo en medicina. | |
IL85945A0 (en) | Pharmaceutical compositions containing 2'-fluoronucleosides and derivatives thereof,certain such novel compounds and their preparation | |
HUT38097A (en) | Process for preparing substituted benzopyrans and pharmaceutical compositions containing them as active substances | |
AP9300561A0 (en) | Antibiotic compounds. | |
MY106231A (en) | Antiviral tetrahydroimidazo [1,4] benzodiazepin-2- thiones. | |
ES8500226A1 (es) | Un procedimiento de preparacion de imino-2-pirrolidinas. | |
ES8105993A1 (es) | Un procedimiento para la preparacion de fenil-quinolicidinas | |
ES480113A1 (es) | Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina. | |
ES8308833A1 (es) | "un metodo para la preparacion de 3-fenil-1-indanaminas". | |
ES8802612A1 (es) | Procedimiento para preparar derivados de benzisoselenazolilo | |
HUT41025A (en) | Process for preparing octahydro-indolizine derivatives and pharmaceutical compositions containing such compounds as active ingredients | |
ES2000681A6 (es) | Un procedimiento para preparar nuevos compuestos de bencilpiperazina | |
ES8308562A1 (es) | Procedimiento para preparar 3',4',5'-trimetoxibenzoato de 1718-dehidorapovincaminol, util como agente activo en preparaciones farmaceuticas | |
ES8502424A1 (es) | Procedimiento para la preparacion de derivados de benzazepina | |
FR2422683A1 (fr) | Nouvelles 6'-n-alkyl- et 6',6'-di-n-alkylfortimicines a et b, utiles notamment comme antibiotiques, et leur procede de preparation | |
MD421C2 (ro) | Derivaţi ai aminoacizilor şi sărurile acido-aditive ale acestora |