ES8801785A1 - Un procedimiento para la preparacion de nuevas azetidinonas sustituidas. - Google Patents

Un procedimiento para la preparacion de nuevas azetidinonas sustituidas.

Info

Publication number
ES8801785A1
ES8801785A1 ES553821A ES553821A ES8801785A1 ES 8801785 A1 ES8801785 A1 ES 8801785A1 ES 553821 A ES553821 A ES 553821A ES 553821 A ES553821 A ES 553821A ES 8801785 A1 ES8801785 A1 ES 8801785A1
Authority
ES
Spain
Prior art keywords
inflammatory
antidegenerative
medicaments
manufacture
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553821A
Other languages
English (en)
Other versions
ES553821A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES553821A0 publication Critical patent/ES553821A0/es
Publication of ES8801785A1 publication Critical patent/ES8801785A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE AZETIDINONAS SUSTITUIDAS DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON ISOCIANATO DE CLOROSULFONILO, SEGUIDA DEL TRATAMIENTO DEL COMPUESTO FORMADO CON UN COMPUESTO DE FORMULA AX O A2O, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE X REPRESENTA UN ATOMO DE HALOGENO, Y A, R, R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIINFLAMATORIOS Y ANTIDEGENERATIVOS.
ES553821A 1985-04-10 1986-04-09 Un procedimiento para la preparacion de nuevas azetidinonas sustituidas. Expired ES8801785A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/721,811 US4680391A (en) 1983-12-01 1985-04-10 Substituted azetidinones as anti-inflammatory and antidegenerative agents

Publications (2)

Publication Number Publication Date
ES553821A0 ES553821A0 (es) 1988-02-16
ES8801785A1 true ES8801785A1 (es) 1988-02-16

Family

ID=24899403

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553821A Expired ES8801785A1 (es) 1985-04-10 1986-04-09 Un procedimiento para la preparacion de nuevas azetidinonas sustituidas.

Country Status (8)

Country Link
US (1) US4680391A (es)
EP (1) EP0199630B1 (es)
JP (1) JPS61289074A (es)
AT (1) ATE56703T1 (es)
CA (1) CA1286304C (es)
DE (1) DE3674237D1 (es)
DK (1) DK159386A (es)
ES (1) ES8801785A1 (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2572727B1 (fr) * 1984-11-02 1989-05-19 Roussel Uclaf Nouveau procede de preparation de 2-azetidinones optiquement actives, produits intermediaires de ce procede et produits finals obtenus par le procede
IL89835A0 (en) * 1988-04-11 1989-12-15 Merck & Co Inc Substituted azetidinones,their preparation and pharmaceutical compositions containing them
FR2640621B1 (fr) * 1988-12-19 1992-10-30 Centre Nat Rech Scient N-aryl-azetidinones, leur procede de preparation et leur utilisation comme inhibiteurs des elastases
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5175283A (en) * 1990-06-04 1992-12-29 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
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US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
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ATE249826T1 (de) * 1992-11-13 2003-10-15 Univ Florida State Isobutenyl-substituierte taxane und deren pharmazeutische zusammensetzungen
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Also Published As

Publication number Publication date
DK159386D0 (da) 1986-04-09
ATE56703T1 (de) 1990-10-15
DE3674237D1 (de) 1990-10-25
EP0199630B1 (en) 1990-09-19
EP0199630A1 (en) 1986-10-29
ES553821A0 (es) 1988-02-16
US4680391A (en) 1987-07-14
CA1286304C (en) 1991-07-16
DK159386A (da) 1986-10-11
JPS61289074A (ja) 1986-12-19

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Effective date: 19970519