ZA855594B - Naphthyl analogs of mevalonolactone and derivatives thereof,processes for their production and their use - Google Patents

Naphthyl analogs of mevalonolactone and derivatives thereof,processes for their production and their use

Info

Publication number
ZA855594B
ZA855594B ZA855594A ZA855594A ZA855594B ZA 855594 B ZA855594 B ZA 855594B ZA 855594 A ZA855594 A ZA 855594A ZA 855594 A ZA855594 A ZA 855594A ZA 855594 B ZA855594 B ZA 855594B
Authority
ZA
South Africa
Prior art keywords
mevalonolactone
derivatives
processes
production
naphthyl analogs
Prior art date
Application number
ZA855594A
Other languages
English (en)
Inventor
Paul Leroy Anderson
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of ZA855594B publication Critical patent/ZA855594B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
ZA855594A 1984-07-24 1985-07-24 Naphthyl analogs of mevalonolactone and derivatives thereof,processes for their production and their use ZA855594B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63380984A 1984-07-24 1984-07-24

Publications (1)

Publication Number Publication Date
ZA855594B true ZA855594B (en) 1987-02-25

Family

ID=24541204

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA855594A ZA855594B (en) 1984-07-24 1985-07-24 Naphthyl analogs of mevalonolactone and derivatives thereof,processes for their production and their use

Country Status (21)

Country Link
JP (1) JPS6137754A (de)
KR (1) KR860001045A (de)
AU (1) AU4522685A (de)
BE (1) BE902914A (de)
DE (1) DE3525256A1 (de)
DK (1) DK333785A (de)
ES (1) ES8705356A1 (de)
FI (1) FI852851L (de)
FR (1) FR2568248A1 (de)
GB (1) GB2162179A (de)
GR (1) GR851805B (de)
HU (1) HUT39142A (de)
IL (1) IL75874A0 (de)
IT (1) IT1200095B (de)
LU (1) LU86012A1 (de)
NL (1) NL8502010A (de)
PH (1) PH21444A (de)
PL (1) PL254654A1 (de)
PT (1) PT80845B (de)
SE (1) SE8503556L (de)
ZA (1) ZA855594B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
US4904646A (en) * 1987-05-22 1990-02-27 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-COA reductase inhibitors
DE3722807A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Neue 3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US4792614A (en) * 1987-08-05 1988-12-20 American Home Products Corporation Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase
US4812583A (en) * 1987-09-11 1989-03-14 American Home Products Corporation Substituted acyloxyalkylphenylethylene inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase
DE3818570A1 (de) * 1988-06-01 1989-12-21 Boehringer Mannheim Gmbh Neue 6-substituierte-4-hydroxy-tetrahydro-pyran -2-on-derivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
CA2185961A1 (en) * 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
KR100836960B1 (ko) 2007-09-07 2008-06-10 주식회사 서울제약 새로운 나이아신 제어방출형 제제

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55132595A (en) * 1979-04-04 1980-10-15 Nec Corp Semiconductor circuit

Also Published As

Publication number Publication date
ES8705356A1 (es) 1987-05-01
ES545454A0 (es) 1987-05-01
FI852851A0 (fi) 1985-07-22
GR851805B (de) 1985-11-26
FI852851L (fi) 1986-01-25
PL254654A1 (en) 1986-08-26
IT1200095B (it) 1989-01-05
KR860001045A (ko) 1986-02-22
GB2162179A (en) 1986-01-29
JPS6137754A (ja) 1986-02-22
DE3525256A1 (de) 1986-01-30
SE8503556D0 (sv) 1985-07-22
PT80845A (en) 1985-08-01
GB8518490D0 (en) 1985-08-29
DK333785D0 (da) 1985-07-22
SE8503556L (sv) 1986-01-25
IL75874A0 (en) 1985-11-29
HUT39142A (en) 1986-08-28
AU4522685A (en) 1986-01-30
DK333785A (da) 1986-01-25
LU86012A1 (fr) 1986-02-12
PT80845B (en) 1987-03-24
PH21444A (en) 1987-10-20
BE902914A (fr) 1986-01-17
NL8502010A (nl) 1986-02-17
FR2568248A1 (fr) 1986-01-31
IT8548385A0 (it) 1985-07-23

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