ZA848388B - Triazine compounds having cardiovascular activity - Google Patents

Triazine compounds having cardiovascular activity

Info

Publication number
ZA848388B
ZA848388B ZA848388A ZA848388A ZA848388B ZA 848388 B ZA848388 B ZA 848388B ZA 848388 A ZA848388 A ZA 848388A ZA 848388 A ZA848388 A ZA 848388A ZA 848388 B ZA848388 B ZA 848388B
Authority
ZA
South Africa
Prior art keywords
triazine compounds
cardiovascular activity
cardiovascular
activity
triazine
Prior art date
Application number
ZA848388A
Other languages
English (en)
Inventor
Geoffrey Allan
David Alan Sawyer
Alistair Ainslie Miller
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA848388B publication Critical patent/ZA848388B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
ZA848388A 1983-10-27 1984-10-26 Triazine compounds having cardiovascular activity ZA848388B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838328757A GB8328757D0 (en) 1983-10-27 1983-10-27 Chemical compounds

Publications (1)

Publication Number Publication Date
ZA848388B true ZA848388B (en) 1986-06-25

Family

ID=10550834

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA848388A ZA848388B (en) 1983-10-27 1984-10-26 Triazine compounds having cardiovascular activity

Country Status (21)

Country Link
US (1) US4649139A (xx)
EP (1) EP0142306A3 (xx)
JP (1) JPS60109577A (xx)
KR (1) KR890000991B1 (xx)
AU (1) AU564667B2 (xx)
CA (1) CA1261328A (xx)
DD (1) DD224033A5 (xx)
DK (1) DK512184A (xx)
ES (1) ES8606304A1 (xx)
FI (1) FI844212L (xx)
GB (1) GB8328757D0 (xx)
GR (1) GR80723B (xx)
HU (1) HU191566B (xx)
IL (1) IL73332A (xx)
MC (1) MC1628A1 (xx)
NZ (1) NZ210000A (xx)
PH (1) PH21926A (xx)
PL (1) PL144899B1 (xx)
PT (1) PT79416B (xx)
SU (1) SU1371500A3 (xx)
ZA (1) ZA848388B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9218113D0 (en) * 1992-08-26 1992-10-14 Lilly Industries Ltd Pharmaceutical compounds
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
AU763244B2 (en) * 2000-01-03 2003-07-17 Rpg Life Sciences Limited A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
IL134730A (en) * 2000-02-25 2003-10-31 Chemagis Ltd Process for preparing substituted benzoyl cyanide amidinohydrazones
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
GB0613836D0 (en) * 2006-07-13 2006-08-23 Univ Greenwich New medical use of triazine derivatives
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
GB0800741D0 (en) 2008-01-16 2008-02-20 Univ Greenwich Cyclic triazo and diazo sodium channel blockers
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB2471713A (en) * 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
GB2471729A (en) * 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN107921046B (zh) 2015-06-12 2022-10-14 格林威治大学 作为干扰素-γ抑制剂的三嗪衍生物
CN109810070B (zh) * 2019-01-29 2022-03-15 太原理工大学 一种含有双酰氧基结构的三嗪酮衍生物及其制备方法和应用
GB202006080D0 (en) 2020-04-24 2020-06-10 Univ Greenwich Cytokine storm syndrome
GB202006076D0 (en) 2020-04-24 2020-06-10 Univ Greenwich Interleukin inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
BG15760A3 (bg) * 1968-06-29 1976-06-21 Неизвестен Метод за получаване на производни на 5-имино- 1, 2, 4- триазина
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
DE2003144C3 (de) * 1970-01-24 1980-01-10 Bayer Ag, 5090 Leverkusen 5-Imino-6-alkyl-1^2,4-triazin-Derivate und Verfahren zu deren Herstellung
DK153787C (da) * 1979-06-01 1989-01-16 Wellcome Found Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
EP0021120B1 (en) * 1979-06-01 1983-04-06 The Wellcome Foundation Limited 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
US4616014A (en) * 1981-10-22 1986-10-07 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same

Also Published As

Publication number Publication date
DK512184D0 (da) 1984-10-26
GB8328757D0 (en) 1983-11-30
NZ210000A (en) 1987-08-31
CA1261328A (en) 1989-09-26
DK512184A (da) 1985-04-28
AU564667B2 (en) 1987-08-20
FI844212L (fi) 1985-04-28
ES8606304A1 (es) 1986-04-16
PH21926A (en) 1988-04-08
PT79416A (en) 1984-11-01
PT79416B (en) 1986-11-13
AU3475884A (en) 1985-05-09
HUT36102A (en) 1985-08-28
FI844212A0 (fi) 1984-10-26
PL250213A1 (en) 1985-12-03
PL144899B1 (en) 1988-07-30
ES537104A0 (es) 1986-04-16
EP0142306A2 (en) 1985-05-22
KR890000991B1 (ko) 1989-04-15
JPS60109577A (ja) 1985-06-15
MC1628A1 (fr) 1985-09-26
EP0142306A3 (en) 1986-11-20
SU1371500A3 (ru) 1988-01-30
GR80723B (en) 1985-02-07
HU191566B (en) 1987-03-30
KR850002964A (ko) 1985-05-28
IL73332A0 (en) 1985-01-31
US4649139A (en) 1987-03-10
DD224033A5 (de) 1985-06-26
IL73332A (en) 1988-06-30

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