ZA837286B - 15-cycloaliphatic derivatives of 13,14-didehydro-carboprostacyclins and process for their preparation - Google Patents

15-cycloaliphatic derivatives of 13,14-didehydro-carboprostacyclins and process for their preparation

Info

Publication number
ZA837286B
ZA837286B ZA837286A ZA837286A ZA837286B ZA 837286 B ZA837286 B ZA 837286B ZA 837286 A ZA837286 A ZA 837286A ZA 837286 A ZA837286 A ZA 837286A ZA 837286 B ZA837286 B ZA 837286B
Authority
ZA
South Africa
Prior art keywords
carboprostacyclins
didehydro
preparation
cycloaliphatic derivatives
cycloaliphatic
Prior art date
Application number
ZA837286A
Other languages
English (en)
Inventor
Nicola Mongelli
Carmelo Gandolfi
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of ZA837286B publication Critical patent/ZA837286B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5435—Cycloaliphatic phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
ZA837286A 1982-10-01 1983-09-29 15-cycloaliphatic derivatives of 13,14-didehydro-carboprostacyclins and process for their preparation ZA837286B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8228143 1982-10-01

Publications (1)

Publication Number Publication Date
ZA837286B true ZA837286B (en) 1984-06-27

Family

ID=10533318

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA837286A ZA837286B (en) 1982-10-01 1983-09-29 15-cycloaliphatic derivatives of 13,14-didehydro-carboprostacyclins and process for their preparation

Country Status (18)

Country Link
US (1) US4514396A (ru)
JP (1) JPS5982339A (ru)
AU (1) AU557580B2 (ru)
BE (1) BE897884A (ru)
CA (1) CA1219861A (ru)
CH (1) CH656120A5 (ru)
DE (1) DE3335389A1 (ru)
DK (1) DK454183A (ru)
FI (1) FI78287C (ru)
FR (1) FR2533917B1 (ru)
GR (1) GR81276B (ru)
HU (1) HU191110B (ru)
IL (1) IL69848A0 (ru)
IT (1) IT1163943B (ru)
NL (1) NL8303363A (ru)
SE (1) SE452613B (ru)
SU (1) SU1272980A3 (ru)
ZA (1) ZA837286B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3526362A1 (de) * 1985-07-19 1987-01-22 Schering Ag Prostacycline, ihre analoga oder prostaglandine und thromboxanantagonisten zur behandlung von thrombotischen und thromboembolischen krankheitsbildern
JPH0680027B2 (ja) * 1985-09-18 1994-10-12 財団法人相模中央化学研究所 プロスタサイクリン類及びこれらを含有する薬剤
JPS62153258A (ja) * 1985-12-26 1987-07-08 Sagami Chem Res Center （１−アルケニル）−ビシクロ〔３．３．０〕オクテン誘導体の製造法
GB2192395B (en) * 1986-07-08 1990-11-14 Kotobuki Seiyaku Co Ltd Carbacyclin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS56145239A (en) * 1980-04-11 1981-11-11 Sumitomo Chem Co Ltd Novel bicyclooctane derivative and its preparation
DE3209702A1 (de) * 1982-03-12 1983-09-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GR77976B (ru) * 1982-03-12 1984-09-25 Schering Ag

Also Published As

Publication number Publication date
BE897884A (fr) 1984-03-30
SE452613B (sv) 1987-12-07
US4514396A (en) 1985-04-30
HU191110B (en) 1987-01-28
IT1163943B (it) 1987-04-08
DK454183A (da) 1984-04-02
AU1968883A (en) 1984-04-05
NL8303363A (nl) 1984-05-01
SE8305386D0 (sv) 1983-09-30
FI833501A (fi) 1984-04-02
FI78287B (fi) 1989-03-31
JPS5982339A (ja) 1984-05-12
IL69848A0 (en) 1983-12-30
IT8323010A0 (it) 1983-09-27
DE3335389A1 (de) 1984-04-05
FI833501A0 (fi) 1983-09-28
CA1219861A (en) 1987-03-31
FI78287C (fi) 1989-07-10
SE8305386L (sv) 1984-04-02
FR2533917A1 (fr) 1984-04-06
AU557580B2 (en) 1986-12-24
GR81276B (ru) 1984-12-11
CH656120A5 (de) 1986-06-13
FR2533917B1 (fr) 1987-11-20
SU1272980A3 (ru) 1986-11-23
DK454183D0 (da) 1983-09-30

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