ZA815066B - A process for enzymatic replacement of the b-30 amino acid in insulins - Google Patents

A process for enzymatic replacement of the b-30 amino acid in insulins

Info

Publication number
ZA815066B
ZA815066B ZA815066A ZA815066A ZA815066B ZA 815066 B ZA815066 B ZA 815066B ZA 815066 A ZA815066 A ZA 815066A ZA 815066 A ZA815066 A ZA 815066A ZA 815066 B ZA815066 B ZA 815066B
Authority
ZA
South Africa
Prior art keywords
ins
amino acid
insulin
ser
insulins
Prior art date
Application number
ZA815066A
Other languages
English (en)
Inventor
Klaus Breddam
Fred Widmer
Jack Taaning Johansen
Original Assignee
Forenede Bryggerier As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forenede Bryggerier As filed Critical Forenede Bryggerier As
Publication of ZA815066B publication Critical patent/ZA815066B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA815066A 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins ZA815066B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Publications (1)

Publication Number Publication Date
ZA815066B true ZA815066B (en) 1983-03-30

Family

ID=8120166

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA815066A ZA815066B (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins

Country Status (14)

Country Link
US (1) US4645740A (ja)
EP (1) EP0045187B1 (ja)
JP (1) JPS642360B2 (ja)
AT (1) ATE9820T1 (ja)
AU (1) AU543687B2 (ja)
CA (1) CA1175372A (ja)
DE (1) DE3166608D1 (ja)
DK (1) DK319780A (ja)
ES (2) ES8300858A1 (ja)
HU (1) HU185668B (ja)
IE (1) IE51620B1 (ja)
SU (2) SU1554766A3 (ja)
WO (1) WO1982000301A1 (ja)
ZA (1) ZA815066B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
WO1982004069A1 (en) * 1981-05-20 1982-11-25 Andresen Finn Hede A process for the preparation of insulin derivatives
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
JPS58501455A (ja) * 1981-09-15 1983-09-01 ノルデイスク　インシユリンラボラトリユ−ム 人インシユリンまたはそのｂ−３０エステルの製造法
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
WO1995007931A1 (en) * 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
AU1112597A (en) * 1996-07-25 1998-02-20 Firma "Nika-Universal" Binary techniques for producing biologically active peptides
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
BR8008024A (pt) * 1979-04-06 1981-03-31 Forenede Bryggerier As Processo para a producao enzimatica de peptideos
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters

Also Published As

Publication number Publication date
ES514463A0 (es) 1983-06-01
AU543687B2 (en) 1985-04-26
AU7450881A (en) 1982-02-16
ES504462A0 (es) 1982-12-01
US4645740A (en) 1987-02-24
ATE9820T1 (de) 1984-10-15
CA1175372A (en) 1984-10-02
HU185668B (en) 1985-03-28
EP0045187B1 (en) 1984-10-10
IE51620B1 (en) 1987-01-21
SU1611217A3 (ru) 1990-11-30
IE811660L (en) 1982-01-24
DK319780A (da) 1982-01-25
SU1554766A3 (ru) 1990-03-30
JPS642360B2 (ja) 1989-01-17
EP0045187A1 (en) 1982-02-03
DE3166608D1 (en) 1984-11-15
JPS57501161A (ja) 1982-07-08
ES8306182A1 (es) 1983-06-01
WO1982000301A1 (en) 1982-02-04
ES8300858A1 (es) 1982-12-01

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