ZA814218B - Immunoregulatory diketopiperazine compounds - Google Patents

Immunoregulatory diketopiperazine compounds

Info

Publication number
ZA814218B
ZA814218B ZA814218A ZA814218A ZA814218B ZA 814218 B ZA814218 B ZA 814218B ZA 814218 A ZA814218 A ZA 814218A ZA 814218 A ZA814218 A ZA 814218A ZA 814218 B ZA814218 B ZA 814218B
Authority
ZA
South Africa
Prior art keywords
immunoregulatory
compounds
diketopiperazine compounds
diketopiperazine
immune system
Prior art date
Application number
ZA814218A
Other languages
English (en)
Inventor
G Haevner
Foe Siong Tjoeng
G Goldstein
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of ZA814218B publication Critical patent/ZA814218B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paper (AREA)
  • Coloring (AREA)
  • Cereal-Derived Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
ZA814218A 1980-06-23 1981-06-22 Immunoregulatory diketopiperazine compounds ZA814218B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/162,228 US4289759A (en) 1980-06-23 1980-06-23 Immunoregulatory diketopiperazine compounds

Publications (1)

Publication Number Publication Date
ZA814218B true ZA814218B (en) 1983-02-23

Family

ID=22584724

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA814218A ZA814218B (en) 1980-06-23 1981-06-22 Immunoregulatory diketopiperazine compounds

Country Status (19)

Country Link
US (1) US4289759A (no)
EP (1) EP0043219B1 (no)
JP (1) JPS5732272A (no)
AT (1) ATE4897T1 (no)
AU (1) AU544522B2 (no)
CA (1) CA1199024A (no)
DE (1) DE3161122D1 (no)
DK (1) DK149591C (no)
ES (1) ES503306A0 (no)
FI (1) FI75563C (no)
GR (1) GR74548B (no)
IE (1) IE51312B1 (no)
IL (1) IL63147A0 (no)
NO (1) NO157862C (no)
NZ (1) NZ197386A (no)
PH (1) PH17520A (no)
PT (1) PT73202B (no)
YU (1) YU42410B (no)
ZA (1) ZA814218B (no)

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US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
DE4027607A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Heterocyclische verbindungen
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
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US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
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US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
WO1997036480A1 (en) 1996-03-29 1997-10-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
DE19681560T1 (de) * 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
EP0904065A4 (en) 1996-06-14 2000-06-14 Emisphere Tech Inc MICRO-ENCLOSED FRAGRANCES AND PRODUCTION METHOD
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) * 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) * 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) * 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) * 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5863944A (en) * 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU2001284697A1 (en) * 2000-08-04 2002-02-18 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
BR0112969A (pt) * 2000-08-04 2004-06-22 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composições contendo-as
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
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US7732403B2 (en) * 2003-05-15 2010-06-08 Dmi Biosciences, Inc. Treatment of T-cell mediated diseases
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WO2008014613A1 (en) * 2006-08-04 2008-02-07 Manus Pharmaceuticals (Canada) Ltd. Multifunctional bioactive compounds
US8217047B2 (en) * 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
AR072114A1 (es) 2008-06-13 2010-08-04 Mannkind Corp Un inhalador de polvo seco y sistema para suministro de farmacos
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8116047B2 (en) * 2008-12-18 2012-02-14 Sandisk Technologies Inc. Electrostatic discharge protective circuit having rise time detector and discharge sustaining circuitry
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
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JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
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BE765030A (fr) * 1970-04-02 1971-08-16 Snam Progetti Composes contenant un noyau de dicetopiperazine et leur procedede fabrication
US4215111A (en) * 1979-03-14 1980-07-29 Ortho Pharmaceutical Corporation Peptides having ubiquitin-like activity

Also Published As

Publication number Publication date
PT73202A (en) 1981-07-01
ES8300718A1 (es) 1982-11-01
FI811950L (fi) 1981-12-24
ES503306A0 (es) 1982-11-01
NZ197386A (en) 1984-07-06
DK149591B (da) 1986-08-04
NO812126L (no) 1981-12-28
EP0043219A1 (en) 1982-01-06
PH17520A (en) 1984-09-13
YU42410B (en) 1988-08-31
DK274881A (da) 1981-12-24
GR74548B (no) 1984-06-29
EP0043219B1 (en) 1983-10-05
AU544522B2 (en) 1985-06-06
JPS5732272A (en) 1982-02-20
ATE4897T1 (de) 1983-10-15
YU157281A (en) 1984-02-29
CA1199024A (en) 1986-01-07
IE811383L (en) 1981-12-23
US4289759A (en) 1981-09-15
FI75563C (fi) 1988-07-11
PT73202B (en) 1983-04-26
NO157862B (no) 1988-02-22
DE3161122D1 (en) 1983-11-10
FI75563B (fi) 1988-03-31
IE51312B1 (en) 1986-11-26
NO157862C (no) 1988-06-01
AU7124681A (en) 1982-01-07
DK149591C (da) 1987-02-09
IL63147A0 (en) 1981-09-13

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