ATE4897T1 - Immunoregulierende diketopiperazin-verbindungen. - Google Patents

Immunoregulierende diketopiperazin-verbindungen.

Info

Publication number
ATE4897T1
ATE4897T1 AT81302798T AT81302798T ATE4897T1 AT E4897 T1 ATE4897 T1 AT E4897T1 AT 81302798 T AT81302798 T AT 81302798T AT 81302798 T AT81302798 T AT 81302798T AT E4897 T1 ATE4897 T1 AT E4897T1
Authority
AT
Austria
Prior art keywords
immunoregulating
compounds
diketopiperazine compounds
diketopiperazine
immune system
Prior art date
Application number
AT81302798T
Other languages
English (en)
Inventor
George Heavner
Foe-Siong Tjoeng
Gideon Goldstein
Original Assignee
Ortho Pharmaceutical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corporation filed Critical Ortho Pharmaceutical Corporation
Application granted granted Critical
Publication of ATE4897T1 publication Critical patent/ATE4897T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paper (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cereal-Derived Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
AT81302798T 1980-06-23 1981-06-22 Immunoregulierende diketopiperazin-verbindungen. ATE4897T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/162,228 US4289759A (en) 1980-06-23 1980-06-23 Immunoregulatory diketopiperazine compounds
EP81302798A EP0043219B1 (de) 1980-06-23 1981-06-22 Immunoregulierende Diketopiperazin-Verbindungen

Publications (1)

Publication Number Publication Date
ATE4897T1 true ATE4897T1 (de) 1983-10-15

Family

ID=22584724

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81302798T ATE4897T1 (de) 1980-06-23 1981-06-22 Immunoregulierende diketopiperazin-verbindungen.

Country Status (19)

Country Link
US (1) US4289759A (de)
EP (1) EP0043219B1 (de)
JP (1) JPS5732272A (de)
AT (1) ATE4897T1 (de)
AU (1) AU544522B2 (de)
CA (1) CA1199024A (de)
DE (1) DE3161122D1 (de)
DK (1) DK149591C (de)
ES (1) ES8300718A1 (de)
FI (1) FI75563C (de)
GR (1) GR74548B (de)
IE (1) IE51312B1 (de)
IL (1) IL63147A0 (de)
NO (1) NO157862C (de)
NZ (1) NZ197386A (de)
PH (1) PH17520A (de)
PT (1) PT73202B (de)
YU (1) YU42410B (de)
ZA (1) ZA814218B (de)

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US5989539A (en) * 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
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US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
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US6084112A (en) * 1995-09-11 2000-07-04 Emisphere Technologies, Inc. Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
US6375983B1 (en) 1996-06-14 2002-04-23 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US5939381A (en) * 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) * 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
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PT1311269E (pt) 2000-08-04 2012-05-10 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composição que contém as mesmas
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AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
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WO2009146320A1 (en) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Therapeutic methods and compounds
CN109568740B (zh) 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8116047B2 (en) * 2008-12-18 2012-02-14 Sandisk Technologies Inc. Electrostatic discharge protective circuit having rise time detector and discharge sustaining circuitry
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (de) 2009-03-11 2013-11-06 MannKind Corporation Gerät, system und verfahren zur messung von widerstand in einem inhaliergerät
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP2496295A1 (de) 2009-11-03 2012-09-12 MannKind Corporation Vorrichtung und verfahren zur simulation von einatmungsanstrengungen
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CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
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WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
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Also Published As

Publication number Publication date
NO157862C (no) 1988-06-01
DK149591B (da) 1986-08-04
GR74548B (de) 1984-06-29
EP0043219A1 (de) 1982-01-06
US4289759A (en) 1981-09-15
DE3161122D1 (en) 1983-11-10
AU7124681A (en) 1982-01-07
ES503306A0 (es) 1982-11-01
EP0043219B1 (de) 1983-10-05
FI75563B (fi) 1988-03-31
FI75563C (fi) 1988-07-11
YU157281A (en) 1984-02-29
AU544522B2 (en) 1985-06-06
PT73202B (en) 1983-04-26
IE811383L (en) 1981-12-23
ZA814218B (en) 1983-02-23
ES8300718A1 (es) 1982-11-01
NZ197386A (en) 1984-07-06
PH17520A (en) 1984-09-13
DK274881A (da) 1981-12-24
PT73202A (en) 1981-07-01
NO157862B (no) 1988-02-22
JPS5732272A (en) 1982-02-20
YU42410B (en) 1988-08-31
CA1199024A (en) 1986-01-07
IL63147A0 (en) 1981-09-13
DK149591C (da) 1987-02-09
FI811950L (fi) 1981-12-24
NO812126L (no) 1981-12-28
IE51312B1 (en) 1986-11-26

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