ZA801970B - Oxazoline and thiazoline derivatives and processes for their preparation - Google Patents
Oxazoline and thiazoline derivatives and processes for their preparationInfo
- Publication number
- ZA801970B ZA801970B ZA00801970A ZA801970A ZA801970B ZA 801970 B ZA801970 B ZA 801970B ZA 00801970 A ZA00801970 A ZA 00801970A ZA 801970 A ZA801970 A ZA 801970A ZA 801970 B ZA801970 B ZA 801970B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- halogen
- optionally substituted
- alkoxy
- phenyl
- Prior art date
Links
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 title 1
- 150000003549 thiazolines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- -1 nitro- Chemical class 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Developing Agents For Electrophotography (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7913864 | 1979-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA801970B true ZA801970B (en) | 1981-04-29 |
Family
ID=10504680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00801970A ZA801970B (en) | 1979-04-20 | 1980-04-02 | Oxazoline and thiazoline derivatives and processes for their preparation |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4409216A (de) |
| EP (1) | EP0018107B1 (de) |
| JP (1) | JPS55141474A (de) |
| AT (1) | ATE2075T1 (de) |
| AU (1) | AU5758880A (de) |
| DE (1) | DE3061396D1 (de) |
| DK (1) | DK167580A (de) |
| ES (2) | ES490675A0 (de) |
| FI (1) | FI801253A (de) |
| GR (1) | GR67301B (de) |
| IE (1) | IE49697B1 (de) |
| IL (1) | IL59803A0 (de) |
| NO (1) | NO801131L (de) |
| ZA (1) | ZA801970B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2075805B1 (es) * | 1993-12-30 | 1996-10-16 | Univ Murcia | Procedimiento para la obtencion de iminooxazolinas n-n'-sustituidas. |
| DE102004008141A1 (de) | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3023103A (en) * | 1960-08-02 | 1962-02-27 | Gen Aniline & Film Corp | Antifoggants and stabilizers for photographic silver halide emulsions |
| DE2205744A1 (de) | 1972-02-08 | 1973-08-09 | Thomae Gmbh Dr K | Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung |
| CS225804B2 (cs) | 1976-03-19 | 1984-02-13 | Mcneilab Inc | Způsob výroby heterocyklických derivátů guanidinu |
| NZ183570A (en) * | 1976-03-19 | 1979-06-08 | Mcneilab Inc | Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity |
| US4089965A (en) * | 1976-03-26 | 1978-05-16 | American Cyanamid Company | Thiazolylphenylguanidines as antirhinovirus agents |
| CA1201119A (en) * | 1978-09-18 | 1986-02-25 | Mcneilab, Inc. | Diaza-cyclic derivatives of guanidine |
| AU5263779A (en) * | 1978-11-29 | 1980-05-29 | Beecham Group Limited | Derivatives of thiazolidin-2-ylidene and oxazolidin-2-ylidene with hypoglycaemic acitivity |
-
1980
- 1980-03-27 AT AT80300949T patent/ATE2075T1/de active
- 1980-03-27 DE DE8080300949T patent/DE3061396D1/de not_active Expired
- 1980-03-27 EP EP80300949A patent/EP0018107B1/de not_active Expired
- 1980-04-02 ZA ZA00801970A patent/ZA801970B/xx unknown
- 1980-04-10 IL IL59803A patent/IL59803A0/xx unknown
- 1980-04-11 US US06/139,284 patent/US4409216A/en not_active Expired - Lifetime
- 1980-04-15 GR GR61687A patent/GR67301B/el unknown
- 1980-04-17 ES ES490675A patent/ES490675A0/es active Granted
- 1980-04-18 FI FI801253A patent/FI801253A/fi not_active Application Discontinuation
- 1980-04-18 DK DK167580A patent/DK167580A/da active IP Right Grant
- 1980-04-18 AU AU57588/80A patent/AU5758880A/en not_active Abandoned
- 1980-04-18 NO NO801131A patent/NO801131L/no unknown
- 1980-04-18 JP JP5155880A patent/JPS55141474A/ja active Pending
- 1980-04-18 IE IE787/80A patent/IE49697B1/en unknown
- 1980-12-09 ES ES497560A patent/ES8200668A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3061396D1 (en) | 1983-01-27 |
| ES497560A0 (es) | 1981-11-16 |
| IL59803A0 (en) | 1980-06-30 |
| US4409216A (en) | 1983-10-11 |
| ES8200668A1 (es) | 1981-11-16 |
| GR67301B (de) | 1981-06-29 |
| IE49697B1 (en) | 1985-11-27 |
| ATE2075T1 (de) | 1983-01-15 |
| FI801253A (fi) | 1980-10-21 |
| AU5758880A (en) | 1980-10-23 |
| JPS55141474A (en) | 1980-11-05 |
| IE800787L (en) | 1980-10-20 |
| DK167580A (da) | 1980-10-21 |
| ES8105306A1 (es) | 1981-05-16 |
| ES490675A0 (es) | 1981-05-16 |
| EP0018107A1 (de) | 1980-10-29 |
| NO801131L (no) | 1980-10-21 |
| EP0018107B1 (de) | 1982-12-22 |
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