ZA756326B - 2-hydroxy-aminoalkyl-derivatives of aminoglycoside antibiotics - Google Patents

2-hydroxy-aminoalkyl-derivatives of aminoglycoside antibiotics

Info

Publication number
ZA756326B
ZA756326B ZA00756326A ZA756326A ZA756326B ZA 756326 B ZA756326 B ZA 756326B ZA 00756326 A ZA00756326 A ZA 00756326A ZA 756326 A ZA756326 A ZA 756326A ZA 756326 B ZA756326 B ZA 756326B
Authority
ZA
South Africa
Prior art keywords
aminoalkyl
hydroxy
derivatives
aminoglycoside antibiotics
aminoglycoside
Prior art date
Application number
ZA00756326A
Other languages
English (en)
Inventor
J Moore
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to IL7650576A priority Critical patent/IL50576A0/xx
Priority to AU18235/76A priority patent/AU491233B2/en
Publication of ZA756326B publication Critical patent/ZA756326B/xx
Priority to PH18973A priority patent/PH14200A/en
Priority to LU75939A priority patent/LU75939A1/xx
Priority to DE2644911A priority patent/DE2644911C3/de
Priority to BE171258A priority patent/BE846962R/xx
Priority to HU76PI544A priority patent/HU175520B/hu
Priority to CA262,724A priority patent/CA1050975A/en
Priority to RO7687926A priority patent/RO74068A/ro
Priority to NL7611021.A priority patent/NL160833C/xx
Priority to CH7812672A priority patent/CH608812A5/xx
Priority to BG7600034371A priority patent/BG25098A3/xx
Priority to FR7630138A priority patent/FR2326931A2/fr
Priority to DD195294A priority patent/DD126341A6/xx
Priority to US05/957,873 priority patent/US4217446A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA00756326A 1974-10-26 1975-10-06 2-hydroxy-aminoalkyl-derivatives of aminoglycoside antibiotics ZA756326B (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IL7650576A IL50576A0 (en) 1975-10-06 1976-09-29 2-hydroxy-omega-aminoalkyl derivatives of aminoglycosides and their preparation
AU18235/76A AU491233B2 (en) 1975-10-06 1976-09-29 2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics
PH18973A PH14200A (en) 1975-10-06 1976-10-04 2-hydroxy-w-aminoalkyl-derivatives of amino glycoside antibiotics
CA262,724A CA1050975A (en) 1975-10-06 1976-10-05 2-HYDROXY-.omega.-AMINOALKYL-DERIVATIVES OF AMINOGLYCOSIDE ANTIBIOTICS
HU76PI544A HU175520B (hu) 1975-10-06 1976-10-05 Sposob poluchenija proizvodnykh 2-deoksi-streptamin-amino-glukozidov
DE2644911A DE2644911C3 (de) 1974-10-26 1976-10-05 Derivate von Kanamycin A oder B, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
BE171258A BE846962R (fr) 1974-10-26 1976-10-05 Nouveaux aminoglycosides de 2-deoxystreptamine, leur preparation et composition antibacterienne les contenant
LU75939A LU75939A1 (xx) 1974-10-26 1976-10-05
RO7687926A RO74068A (ro) 1975-10-06 1976-10-06 Procedeu pentru prepararea 1-n-(s)-2-hidroxi-6-aminohexil-kanam cina a
NL7611021.A NL160833C (nl) 1975-10-06 1976-10-06 Werkwijze voor de bereiding van anti-bacteriele kanamycinederivaten en van preparaten die ze bevatten.
CH7812672A CH608812A5 (xx) 1974-10-26 1976-10-06
BG7600034371A BG25098A3 (en) 1975-10-06 1976-10-06 A method of obtaining 2-deoxistreptamine amineglucosides
FR7630138A FR2326931A2 (fr) 1975-10-06 1976-10-06 Nouveaux aminoglycosides de 2-deoxystreptamine, leur preparation et composition antibacterienne les contenant
DD195294A DD126341A6 (xx) 1975-10-06 1976-10-15
US05/957,873 US4217446A (en) 1974-10-26 1978-11-06 ωAmino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4641274A GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides

Publications (1)

Publication Number Publication Date
ZA756326B true ZA756326B (en) 1976-09-29

Family

ID=10441164

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00756326A ZA756326B (en) 1974-10-26 1975-10-06 2-hydroxy-aminoalkyl-derivatives of aminoglycoside antibiotics

Country Status (28)

Country Link
JP (1) JPS5519237B2 (xx)
AR (1) AR205593A1 (xx)
AT (1) AT340051B (xx)
BE (1) BE834864A (xx)
BG (1) BG24821A3 (xx)
CA (1) CA1039275A (xx)
CH (1) CH601339A5 (xx)
CS (1) CS195712B2 (xx)
DD (1) DD122522A5 (xx)
DE (1) DE2547738C3 (xx)
DK (1) DK147075C (xx)
EG (1) EG11975A (xx)
ES (1) ES442051A1 (xx)
FI (1) FI752951A (xx)
FR (1) FR2289202A1 (xx)
GB (1) GB1464401A (xx)
HU (1) HU172060B (xx)
IE (1) IE42452B1 (xx)
IL (1) IL48263A (xx)
LU (1) LU73644A1 (xx)
NL (1) NL162081C (xx)
NZ (1) NZ179050A (xx)
PH (1) PH12782A (xx)
PL (1) PL99933B1 (xx)
RO (1) RO72878A (xx)
SE (1) SE7511945L (xx)
SU (1) SU617017A3 (xx)
ZA (1) ZA756326B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000473B1 (en) * 1977-06-24 1981-03-11 Scherico Ltd. Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives
JPS5488241A (en) * 1977-12-21 1979-07-13 Kyowa Hakko Kogyo Co Ltd Novel fortimicin a derivative
JPS57118475U (xx) * 1981-01-14 1982-07-22

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606076A5 (xx) * 1973-08-06 1978-10-13 Scherico Ltd

Also Published As

Publication number Publication date
AU8598175A (en) 1976-12-09
GB1464401A (en) 1977-02-16
FR2289202B1 (xx) 1978-11-10
PL99933B1 (pl) 1978-08-31
DK481175A (da) 1976-04-27
RO72878A (ro) 1983-07-07
DE2547738A1 (de) 1976-05-06
FR2289202A1 (fr) 1976-05-28
IL48263A0 (en) 1975-12-31
CA1039275A (en) 1978-09-26
NL7512465A (nl) 1976-04-28
BG24821A3 (en) 1978-05-12
EG11975A (en) 1978-06-30
LU73644A1 (xx) 1977-05-31
DD122522A5 (xx) 1976-10-12
AT340051B (de) 1977-11-25
NL162081C (nl) 1980-04-15
CH601339A5 (xx) 1978-07-14
DE2547738C3 (de) 1978-08-03
NL162081B (nl) 1979-11-15
BE834864A (fr) 1976-04-26
IE42452L (en) 1976-04-26
JPS5168543A (xx) 1976-06-14
FI752951A (xx) 1976-04-27
JPS5519237B2 (xx) 1980-05-24
IE42452B1 (en) 1980-08-13
HU172060B (hu) 1978-05-28
PH12782A (en) 1979-08-17
ATA809575A (de) 1977-03-15
DK147075C (da) 1984-11-05
SE7511945L (sv) 1976-04-27
ES442051A1 (es) 1977-04-01
DK147075B (da) 1984-04-02
CS195712B2 (en) 1980-02-29
DE2547738B2 (de) 1977-12-01
SU617017A3 (ru) 1978-07-25
AR205593A1 (es) 1976-05-14
IL48263A (en) 1978-03-10
RO72878B (ro) 1983-06-30
NZ179050A (en) 1978-03-06

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