IE42452L - Aminoglycosides - Google Patents

Aminoglycosides

Info

Publication number
IE42452L
IE42452L IE752316A IE231675A IE42452L IE 42452 L IE42452 L IE 42452L IE 752316 A IE752316 A IE 752316A IE 231675 A IE231675 A IE 231675A IE 42452 L IE42452 L IE 42452L
Authority
IE
Ireland
Prior art keywords
kanamycin
hydroxybutyl
oct
amino
hours
Prior art date
Application number
IE752316A
Other versions
IE42452B1 (en
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of IE42452L publication Critical patent/IE42452L/en
Publication of IE42452B1 publication Critical patent/IE42452B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1464401 Silylated aminoglycoside PFIZER Ltd 24 Oct 1975 [26 Oct 1974] 46412/74 Heading C3S [Also in Division C2] The penta - N - acetyl - octa - O - trimethylsilyl derivative of 1 - N - [(S) - 4 - amino - 2- hydroxybutyl] - kanamycin A is prepared by treating 1 - N - [(S) - 4 - amino - 2 - hydroxybutyl]-kanamycin A with acetic anhydride in methanol at room temperature for 24 hours, followed by a 2 : 1 mixture of hexamethyldisilazane and trimethylchlorosilane at room temperature for 24 hours. [GB1464401A]
IE2316/75A 1974-10-26 1975-10-24 Aminoglycosides IE42452B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4641274A GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides

Publications (2)

Publication Number Publication Date
IE42452L true IE42452L (en) 1976-04-26
IE42452B1 IE42452B1 (en) 1980-08-13

Family

ID=10441164

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2316/75A IE42452B1 (en) 1974-10-26 1975-10-24 Aminoglycosides

Country Status (28)

Country Link
JP (1) JPS5519237B2 (en)
AR (1) AR205593A1 (en)
AT (1) AT340051B (en)
BE (1) BE834864A (en)
BG (1) BG24821A3 (en)
CA (1) CA1039275A (en)
CH (1) CH601339A5 (en)
CS (1) CS195712B2 (en)
DD (1) DD122522A5 (en)
DE (1) DE2547738C3 (en)
DK (1) DK147075C (en)
EG (1) EG11975A (en)
ES (1) ES442051A1 (en)
FI (1) FI752951A (en)
FR (1) FR2289202A1 (en)
GB (1) GB1464401A (en)
HU (1) HU172060B (en)
IE (1) IE42452B1 (en)
IL (1) IL48263A (en)
LU (1) LU73644A1 (en)
NL (1) NL162081C (en)
NZ (1) NZ179050A (en)
PH (1) PH12782A (en)
PL (1) PL99933B1 (en)
RO (1) RO72878A (en)
SE (1) SE7511945L (en)
SU (1) SU617017A3 (en)
ZA (1) ZA756326B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2860513D1 (en) * 1977-06-24 1981-04-09 Scherico Ltd Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives
JPS5488241A (en) * 1977-12-21 1979-07-13 Kyowa Hakko Kogyo Co Ltd Novel fortimicin a derivative
JPS57118475U (en) * 1981-01-14 1982-07-22

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606076A5 (en) * 1973-08-06 1978-10-13 Scherico Ltd

Also Published As

Publication number Publication date
CA1039275A (en) 1978-09-26
BG24821A3 (en) 1978-05-12
CH601339A5 (en) 1978-07-14
ZA756326B (en) 1976-09-29
IE42452B1 (en) 1980-08-13
FR2289202A1 (en) 1976-05-28
JPS5168543A (en) 1976-06-14
NL162081C (en) 1980-04-15
PL99933B1 (en) 1978-08-31
EG11975A (en) 1978-06-30
RO72878B (en) 1983-06-30
PH12782A (en) 1979-08-17
IL48263A0 (en) 1975-12-31
SE7511945L (en) 1976-04-27
AU8598175A (en) 1976-12-09
LU73644A1 (en) 1977-05-31
AR205593A1 (en) 1976-05-14
DK147075C (en) 1984-11-05
DK147075B (en) 1984-04-02
JPS5519237B2 (en) 1980-05-24
BE834864A (en) 1976-04-26
RO72878A (en) 1983-07-07
DE2547738C3 (en) 1978-08-03
NZ179050A (en) 1978-03-06
ATA809575A (en) 1977-03-15
SU617017A3 (en) 1978-07-25
DK481175A (en) 1976-04-27
CS195712B2 (en) 1980-02-29
DD122522A5 (en) 1976-10-12
GB1464401A (en) 1977-02-16
FI752951A (en) 1976-04-27
NL162081B (en) 1979-11-15
NL7512465A (en) 1976-04-28
FR2289202B1 (en) 1978-11-10
DE2547738B2 (en) 1977-12-01
DE2547738A1 (en) 1976-05-06
HU172060B (en) 1978-05-28
ES442051A1 (en) 1977-04-01
AT340051B (en) 1977-11-25
IL48263A (en) 1978-03-10

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