GB1464401A - Aminoglycosides - Google Patents

Aminoglycosides

Info

Publication number
GB1464401A
GB1464401A GB4641274A GB4641274A GB1464401A GB 1464401 A GB1464401 A GB 1464401A GB 4641274 A GB4641274 A GB 4641274A GB 4641274 A GB4641274 A GB 4641274A GB 1464401 A GB1464401 A GB 1464401A
Authority
GB
United Kingdom
Prior art keywords
kanamycin
hydroxybutyl
oct
amino
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4641274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB4641274A priority Critical patent/GB1464401A/en
Priority to AR260909A priority patent/AR205593A1/en
Priority to ZA00756326A priority patent/ZA756326B/en
Priority to IL48263A priority patent/IL48263A/en
Priority to PH17665A priority patent/PH12782A/en
Priority to EG627/75A priority patent/EG11975A/en
Priority to FI752951A priority patent/FI752951A/fi
Priority to RO7583664A priority patent/RO72878A/en
Priority to AT809575A priority patent/AT340051B/en
Priority to CS757161A priority patent/CS195712B2/en
Priority to AU85981/75A priority patent/AU478659B2/en
Priority to LU73644A priority patent/LU73644A1/xx
Priority to BG7500031312A priority patent/BG24821A3/en
Priority to DE2547738A priority patent/DE2547738C3/en
Priority to ES442051A priority patent/ES442051A1/en
Priority to PL1975184233A priority patent/PL99933B1/en
Priority to IE2316/75A priority patent/IE42452B1/en
Priority to DK481175A priority patent/DK147075C/en
Priority to SE7511945A priority patent/SE7511945L/en
Priority to CA238,246A priority patent/CA1039275A/en
Priority to NZ179050A priority patent/NZ179050A/en
Priority to HU75PI00000496A priority patent/HU172060B/en
Priority to CH1380675A priority patent/CH601339A5/xx
Priority to SU752184101A priority patent/SU617017A3/en
Priority to DD189046A priority patent/DD122522A5/xx
Priority to BE161248A priority patent/BE834864A/en
Priority to FR7532662A priority patent/FR2289202A1/en
Priority to JP12823775A priority patent/JPS5519237B2/ja
Priority to NL7512465.A priority patent/NL162081C/en
Priority to GB1542576A priority patent/GB1512475A/en
Priority to BE171258A priority patent/BE846962R/en
Priority to LU75939A priority patent/LU75939A1/xx
Priority to DE2644911A priority patent/DE2644911C3/en
Priority to CH7812672A priority patent/CH608812A5/xx
Publication of GB1464401A publication Critical patent/GB1464401A/en
Priority to US05/957,873 priority patent/US4217446A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1464401 Silylated aminoglycoside PFIZER Ltd 24 Oct 1975 [26 Oct 1974] 46412/74 Heading C3S [Also in Division C2] The penta - N - acetyl - octa - O - trimethylsilyl derivative of 1 - N - [(S) - 4 - amino - 2- hydroxybutyl] - kanamycin A is prepared by treating 1 - N - [(S) - 4 - amino - 2 - hydroxybutyl]-kanamycin A with acetic anhydride in methanol at room temperature for 24 hours, followed by a 2 : 1 mixture of hexamethyldisilazane and trimethylchlorosilane at room temperature for 24 hours.
GB4641274A 1974-10-26 1974-10-26 Aminoglycosides Expired GB1464401A (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB4641274A GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides
AR260909A AR205593A1 (en) 1974-10-26 1975-01-01 PROCEDURE TO PREPARE 2-DEOXYSTREPTAMINE AMINOGLYCOSIDES
ZA00756326A ZA756326B (en) 1974-10-26 1975-10-06 2-hydroxy-aminoalkyl-derivatives of aminoglycoside antibiotics
IL48263A IL48263A (en) 1974-10-26 1975-10-07 2-hydroxy-omega-aminoalkyl derivates of aminoglycoside antibiotics,their preparation and pharmaceutical compositions containing them
PH17665A PH12782A (en) 1974-10-26 1975-10-16 Z-hydroxy-w-aminoalkyl derivatives of aminoglycoside antibiotics
EG627/75A EG11975A (en) 1974-10-26 1975-10-22 Process for preparing of 2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics
FI752951A FI752951A (en) 1974-10-26 1975-10-22
RO7583664A RO72878A (en) 1974-10-26 1975-10-22 PROCESS FOR THE PREPARATION OF 2-DEZOXYSTREPTAMINOAMINO GLYCOSIDES
AT809575A AT340051B (en) 1974-10-26 1975-10-23 PROCESS FOR THE PREPARATION OF NEW 2-DEOXYSTREPTAMINAMINOGLYCOSIDES AND THEIR ACID ADDITION SALTS
CS757161A CS195712B2 (en) 1974-10-26 1975-10-23 Method of producing novel aminoglycosides of 2-deoxystreptsmine
AU85981/75A AU478659B2 (en) 1974-10-26 1975-10-23 2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics
DK481175A DK147075C (en) 1974-10-26 1975-10-24 METHOD OF ANALOGY FOR THE PREPARATION OF CANAMYCINE A OR CANAMYCINE B DERIVATIVES OR SALTS THEREOF
DD189046A DD122522A5 (en) 1974-10-26 1975-10-24
DE2547738A DE2547738C3 (en) 1974-10-26 1975-10-24 Derivatives of kanamycin A or B, processes for their preparation and medicaments containing them
ES442051A ES442051A1 (en) 1974-10-26 1975-10-24 Aminoglycosides
PL1975184233A PL99933B1 (en) 1974-10-26 1975-10-24 METHOD OF MAKING NEW AMINOGLICOSIDES 2-DESOXYSTREPTAMINE
IE2316/75A IE42452B1 (en) 1974-10-26 1975-10-24 Aminoglycosides
LU73644A LU73644A1 (en) 1974-10-26 1975-10-24
SE7511945A SE7511945L (en) 1974-10-26 1975-10-24 ANTIBACTERIAL MEASURES JUST MADE TO PRODUCE THEM
CA238,246A CA1039275A (en) 1974-10-26 1975-10-24 2-hydroxy-w-aminoalkyl-derivatives of aminoglycoside antibiotics
NZ179050A NZ179050A (en) 1974-10-26 1975-10-24 Antibacterial 2-deoxystreptamine amino-glycosides (2-hydroxy-w-aminoalkyl derivatiues): and pharmaceutical compositions
HU75PI00000496A HU172060B (en) 1974-10-26 1975-10-24 Process for producing 2-deoxy-streptamin-amino-glycosides
CH1380675A CH601339A5 (en) 1974-10-26 1975-10-24
SU752184101A SU617017A3 (en) 1974-10-26 1975-10-24 Method of obtaining 2-deoxystreptamin-amineglycosides or salts thereof
BG7500031312A BG24821A3 (en) 1974-10-26 1975-10-24 Method of obtaining 2-desoxystreptamine aminoglycosides
BE161248A BE834864A (en) 1974-10-26 1975-10-24 NEW AMINOGLYCOSIDES OF 2-DEOXYSTREPTAMINE, THEIR PREPARATION AND ANTIBACTERIAL COMPOSITION CONTAINING THEM
FR7532662A FR2289202A1 (en) 1974-10-26 1975-10-24 NEW AMINOGLYCOSIDES OF 2-DEOXYSTREPTAMINE, THEIR PREPARATION AND ANTIBACTERIAL COMPOSITION CONTAINING THEM
JP12823775A JPS5519237B2 (en) 1974-10-26 1975-10-24
NL7512465.A NL162081C (en) 1974-10-26 1975-10-24 PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH ANTIBACTERIAL PROPERTIES, FORMED PREPARATION AND PROCESS FOR THE PREPARATION OF AN ACTIVE SUBSTANCE SUITABLE FOR USE IN THE FOREGOING PROCESS
GB1542576A GB1512475A (en) 1974-10-26 1976-04-15 Aminoglycosides
BE171258A BE846962R (en) 1974-10-26 1976-10-05 NEW AMINOGLYCOSIDES OF 2-DEOXYSTREPTAMINE, THEIR PREPARATION AND ANTIBACTERIAL COMPOSITION CONTAINING THEM
LU75939A LU75939A1 (en) 1974-10-26 1976-10-05
DE2644911A DE2644911C3 (en) 1974-10-26 1976-10-05 Derivatives of kanamycin A or B, processes for their preparation and medicaments containing them
CH7812672A CH608812A5 (en) 1974-10-26 1976-10-06
US05/957,873 US4217446A (en) 1974-10-26 1978-11-06 ωAmino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4641274A GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides

Publications (1)

Publication Number Publication Date
GB1464401A true GB1464401A (en) 1977-02-16

Family

ID=10441164

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4641274A Expired GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides

Country Status (28)

Country Link
JP (1) JPS5519237B2 (en)
AR (1) AR205593A1 (en)
AT (1) AT340051B (en)
BE (1) BE834864A (en)
BG (1) BG24821A3 (en)
CA (1) CA1039275A (en)
CH (1) CH601339A5 (en)
CS (1) CS195712B2 (en)
DD (1) DD122522A5 (en)
DE (1) DE2547738C3 (en)
DK (1) DK147075C (en)
EG (1) EG11975A (en)
ES (1) ES442051A1 (en)
FI (1) FI752951A (en)
FR (1) FR2289202A1 (en)
GB (1) GB1464401A (en)
HU (1) HU172060B (en)
IE (1) IE42452B1 (en)
IL (1) IL48263A (en)
LU (1) LU73644A1 (en)
NL (1) NL162081C (en)
NZ (1) NZ179050A (en)
PH (1) PH12782A (en)
PL (1) PL99933B1 (en)
RO (1) RO72878A (en)
SE (1) SE7511945L (en)
SU (1) SU617017A3 (en)
ZA (1) ZA756326B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000473B1 (en) * 1977-06-24 1981-03-11 Scherico Ltd. Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives
JPS5488241A (en) * 1977-12-21 1979-07-13 Kyowa Hakko Kogyo Co Ltd Novel fortimicin a derivative
JPS57118475U (en) * 1981-01-14 1982-07-22

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606076A5 (en) * 1973-08-06 1978-10-13 Scherico Ltd

Also Published As

Publication number Publication date
IL48263A (en) 1978-03-10
PH12782A (en) 1979-08-17
NL162081B (en) 1979-11-15
ZA756326B (en) 1976-09-29
DE2547738B2 (en) 1977-12-01
BE834864A (en) 1976-04-26
DK147075C (en) 1984-11-05
FI752951A (en) 1976-04-27
ES442051A1 (en) 1977-04-01
DK481175A (en) 1976-04-27
SE7511945L (en) 1976-04-27
DE2547738A1 (en) 1976-05-06
DD122522A5 (en) 1976-10-12
BG24821A3 (en) 1978-05-12
JPS5519237B2 (en) 1980-05-24
JPS5168543A (en) 1976-06-14
CH601339A5 (en) 1978-07-14
EG11975A (en) 1978-06-30
SU617017A3 (en) 1978-07-25
CA1039275A (en) 1978-09-26
NL7512465A (en) 1976-04-28
RO72878B (en) 1983-06-30
IE42452B1 (en) 1980-08-13
PL99933B1 (en) 1978-08-31
FR2289202B1 (en) 1978-11-10
AU8598175A (en) 1976-12-09
DK147075B (en) 1984-04-02
IE42452L (en) 1976-04-26
AR205593A1 (en) 1976-05-14
NL162081C (en) 1980-04-15
LU73644A1 (en) 1977-05-31
HU172060B (en) 1978-05-28
IL48263A0 (en) 1975-12-31
NZ179050A (en) 1978-03-06
FR2289202A1 (en) 1976-05-28
ATA809575A (en) 1977-03-15
DE2547738C3 (en) 1978-08-03
AT340051B (en) 1977-11-25
RO72878A (en) 1983-07-07
CS195712B2 (en) 1980-02-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee