ZA201702985B - Improved il-6 antibodies - Google Patents

Improved il-6 antibodies

Info

Publication number
ZA201702985B
ZA201702985B ZA201702985A ZA201702985A ZA201702985B ZA 201702985 B ZA201702985 B ZA 201702985B ZA 201702985 A ZA201702985 A ZA 201702985A ZA 201702985 A ZA201702985 A ZA 201702985A ZA 201702985 B ZA201702985 B ZA 201702985B
Authority
ZA
South Africa
Prior art keywords
antibodies
improved
Prior art date
Application number
ZA201702985A
Other languages
English (en)
Inventor
Michael March Schmidt
Alison Tisdale
Eric Steven Furfine
Grigorios Zarbis-Papastoitsis
Original Assignee
Eleven Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eleven Biotherapeutics Inc filed Critical Eleven Biotherapeutics Inc
Publication of ZA201702985B publication Critical patent/ZA201702985B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA201702985A 2014-11-07 2017-04-28 Improved il-6 antibodies ZA201702985B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US201562247705P 2015-10-28 2015-10-28
PCT/US2015/059532 WO2016073890A1 (en) 2014-11-07 2015-11-06 Improved il-6 antibodies

Publications (1)

Publication Number Publication Date
ZA201702985B true ZA201702985B (en) 2019-10-30

Family

ID=54602042

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA201702985A ZA201702985B (en) 2014-11-07 2017-04-28 Improved il-6 antibodies

Country Status (33)

Country Link
US (3) US11142571B2 (show.php)
EP (3) EP3215530B9 (show.php)
JP (1) JP6594438B2 (show.php)
KR (2) KR102636726B1 (show.php)
CN (1) CN107249631B (show.php)
AU (1) AU2015342882B2 (show.php)
CA (1) CA2965689C (show.php)
CL (1) CL2017001135A1 (show.php)
CO (1) CO2017005404A2 (show.php)
CR (1) CR20170231A (show.php)
DK (2) DK4268843T3 (show.php)
EA (1) EA035199B1 (show.php)
ES (2) ES2756275T3 (show.php)
FI (1) FI4268843T3 (show.php)
HR (2) HRP20191945T1 (show.php)
HU (1) HUE046181T2 (show.php)
IL (1) IL251858B (show.php)
LT (1) LT4268843T (show.php)
MA (2) MA62787B1 (show.php)
MX (2) MX385206B (show.php)
MY (1) MY185114A (show.php)
PE (1) PE20171107A1 (show.php)
PH (1) PH12017500809B1 (show.php)
PL (2) PL4268843T3 (show.php)
PT (2) PT3215530T (show.php)
RS (2) RS59805B1 (show.php)
SA (1) SA517381458B1 (show.php)
SG (2) SG10202103420PA (show.php)
SI (1) SI3215530T1 (show.php)
SM (1) SMT202500415T1 (show.php)
UA (1) UA122673C2 (show.php)
WO (1) WO2016073890A1 (show.php)
ZA (1) ZA201702985B (show.php)

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CN110612124B (zh) 2017-03-22 2024-04-16 豪夫迈·罗氏有限公司 用于治疗眼部病症的优化的抗体组合物
CN110891611B (zh) 2017-03-22 2024-03-29 阿森迪斯制药公司 水凝胶交联透明质酸前药组合物和方法
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
CR20220461A (es) 2020-03-13 2022-10-21 Genentech Inc Anticuerpos anti-interleucina-33 y usos de estos
CN120757644A (zh) 2020-03-24 2025-10-10 基因泰克公司 Tie2结合剂及其使用方法
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CN114525235B (zh) * 2022-02-25 2023-07-14 郑州大学 一种提高人表皮生长因子分泌生产效率的方法
CN115343483B (zh) * 2022-08-12 2024-11-26 苏州邦器生物技术有限公司 一种自身免疫性糖尿病检测用试剂盒及其制备方法
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MA51554A (fr) 2020-11-18
ES2756275T3 (es) 2020-04-27
MY185114A (en) 2021-04-30
KR102636726B1 (ko) 2024-02-13
PT3215530T (pt) 2019-11-21
HK1244008A1 (en) 2018-07-27
HRP20251312T1 (hr) 2025-12-05
KR102770849B1 (ko) 2025-02-20
ES3051832T3 (en) 2025-12-30
CR20170231A (es) 2017-09-25
SMT202500415T1 (it) 2026-01-12
PT4268843T (pt) 2025-10-31
EP3632931A1 (en) 2020-04-08
PL4268843T3 (pl) 2025-12-15
IL251858B (en) 2022-09-01
JP2017535285A (ja) 2017-11-30
HRP20191945T1 (hr) 2020-01-24
EP3215530B9 (en) 2020-09-09
SI3215530T1 (sl) 2020-02-28
EP4268843A3 (en) 2023-12-27
RS59805B1 (sr) 2020-02-28
US20220169719A1 (en) 2022-06-02
NZ731090A (en) 2024-03-22
JP6594438B2 (ja) 2019-10-23
PH12017500809B1 (en) 2023-09-20
EA201791005A1 (ru) 2017-09-29
EP3215530A1 (en) 2017-09-13
SG10202103420PA (en) 2021-05-28
RS67353B1 (sr) 2025-11-28
CN107249631A (zh) 2017-10-13
HUE046181T2 (hu) 2020-02-28
KR20240023450A (ko) 2024-02-21
EA035199B1 (ru) 2020-05-14
PH12017500809A1 (en) 2017-10-02
CA2965689A1 (en) 2016-05-12
CN107249631B (zh) 2021-11-23
AU2015342882A1 (en) 2017-05-18
MX2021008663A (es) 2021-08-19
CO2017005404A2 (es) 2017-10-31
MX2017005992A (es) 2017-09-15
LT4268843T (lt) 2025-11-25
UA122673C2 (uk) 2020-12-28
EP4268843B1 (en) 2025-09-03
MX385206B (es) 2025-03-14
CL2017001135A1 (es) 2017-12-15
BR112017008672A2 (pt) 2018-03-20
DK3215530T3 (da) 2019-11-25
US20250059270A1 (en) 2025-02-20
PL3215530T3 (pl) 2020-05-18
US11142571B2 (en) 2021-10-12
PE20171107A1 (es) 2017-08-07
FI4268843T3 (fi) 2025-11-14
ES2756275T9 (es) 2020-10-29
AU2015342882B2 (en) 2021-05-20
KR20170077196A (ko) 2017-07-05
SG11201703574VA (en) 2017-05-30
IL251858A0 (en) 2017-06-29
EP3215530B1 (en) 2019-08-21
EP4268843A2 (en) 2023-11-01
WO2016073890A1 (en) 2016-05-12
DK4268843T3 (da) 2025-11-10
MA62787B1 (fr) 2025-11-28
CA2965689C (en) 2022-03-22
SA517381458B1 (ar) 2020-07-09
US20190194312A1 (en) 2019-06-27

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